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  • 1
    Electronic Resource
    Electronic Resource
    Adenosine deaminase and adenosine uptake inhibitions facilitate ventilation in rats (1989)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 340 (1989), S. 230-238 
    Details
    ISSN: 1432-1912
    Keywords: Adenosine ; EHNA ; Dipyridamole ; Respiration ; Rat carotid body
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of intracarotid (i. c.) infusions of the adenosine deaminase inhibitor, erythro-9-(2-hydroxy-3nonyl)adenine (EHNA) and of the adenosine uptake blocker, dipyridamole on spontaneous ventilation were studied in rats anaesthetized with sodium pentobarbitone. Both EHNA and dipyridamole mimicked the excitatory effect of adenosine on respiration increasing in a dose-dependent manner respiratory ventilation determined as increases in tidal volume (V T), respiratory frequency (f) and minute volume (V E). These excitatory effects were abolished after section of the carotid sinus nerves. The excitatory effect of EHNA on respiration was prevented by adenosine deaminase and antagonized by 1,3-dipropyl-8(p-sulfophenyl)xanthine (DPSPX). DPSPX also antagonized the excitatory effect of dipyridamole on respiration. Both EHNA and dipyridamole in doses virtually devoid of effect on respiration potentiated the excitatory effect of exogenous adenosine on respiration. Two different effects on respiration were observed during i.c. infusions of cumulative doses of DPSPX: one inhibitory, not present in glomectomized animals and another, excitatory, present in both glomectomized and non-glomectomized animals. It is concluded that endogenous adenosine could be involved in respiration mediated through carotid body chemoreceptors and that the nucleoside is inactivated at this level by deamination and uptake.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00168974
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Separation of adenosine triphosphate and its degradation products in innervated muscle of the frog by reverse phase high-performance liquid chromatography (1989)
    Springer
    Chromatographia 28 (1989), S. 610-612 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Adenosine phosphates ; Adenosine phosphate degradation products ; Innervated frog muscle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Adenosine mono-, di- and triphosphates, inosine monophosphates, adenosine, inosine and hypoxanthine were separated in a single run by high-performance liquid chromatography with UV detection. AC-18 reversephase column was used. An isocratic elution with 100mM phosphate buffer (KH2PO4) pH6.5 and 1.2% methanol, followed by a 5 minute linear gradient up to 15% methanol after the 10th minute was performed during each run with a flow rate of 1.25ml/min. The time required for each analysis was 25 minutes. The detection limit for each substance ranged from 3 to 5 pmol. All the substances under study were detected in the incubation medium when adenosine triphosphate was exogenously applied to the innervated frog sartorius muscle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02260687
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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