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  • 1
    Electronic Resource
    Electronic Resource
    Glucose metabolism and protective biochemical mechanisms in a rat brain affected by kaolin-induced hydrocephalus (1997)
    Springer
    Child's nervous system 13 (1997), S. 183-188 
    Details
    ISSN: 1433-0350
    Keywords: Key words Hydrocephalus ; Lactate dehydrogenase ; LDH isozyme ; Isocitrate dehydrogenase ; Lactate ; Adenosine triphosphate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To clarify glucose metabolism in a hydrocephalic rat brain, substances related to glycolytic metabolism were biochemically measured. Kaolin-induced hydrocephalic rats were sacrificed and lactate dehydrogenase (LDH), LDH isozyme, lactate, adenosine triphosphate (ATP), and isocitrate dehydrogenase (ICDH) were measured in the following regions: cortex, thalamus, midbrain, hippocampus, cerebellum, and pons with medulla. During the development of hydrocephalus, lactate and LDH increased in most regions, the LDH M-subunit increased in the cortex, and ICDH decreased in most regions. However, ATP levels did not change. The increases in lactate, LDH and M-subunit suggested an anaerobic environment in the cell leading to activation of the anaerobic glycolysis. The decrease in ICDH represented a diminution of the tricarboxylic acid cycle. Through these alterations, the ATP level can be kept constant during the course of hydrocephalus, allowing the brain to create a better biochemical milieu.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003810050066
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Infantile acute subdural hematoma (1987)
    Springer
    Child's nervous system 3 (1987), S. 19-22 
    Details
    ISSN: 1433-0350
    Keywords: Head injury ; Acute subdural hematoma ; Chronic subdural hematoma ; Infant ; Subdural effusion ; Subdural membrane
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A retrospective analysis of the infantile acute subdural hematoma was made with special reference to its pathogenesis. In 11 of 15 cases, the hematomas were bilateral or a contralateral subdural fluid collection was present. In 7 of 11 patients who underwent operation the collection was bloody fluid and/or clotted blood. In 3 patients, a subdural membrane, as seen in adult chronic subdural hematoma, was found. In only 1 patient with unilateral hematoma was clotted blood present without subdural membrane. The thickest collection of clotted blood was in the parasagittal region. It is postulated that in most cases hemorrhage occurs after minor head injury, from the bridging veins near the superior sagittal sinus, into a pre-existing subdural fluid collection such as chronic subdural hematoma or subdural effusion with craniocerebral disproportion, and that infants without intracranial disproportion are unlikely to have acute subdural hematoma caused by minor head injury.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00707188
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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