ISSN:
1432-0533
Keywords:
Key words Mouse skeletal muscle
;
Adenovirus vector
;
lacZ gene
;
Myofiber type
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract We show the efficient transduction and expression of the lacZ gene in the skeletal muscle of adult C57BL/10ScSn mice after adenovirus-mediated gene transfer. Of the myofibers in the tibialis anterior muscle 62% were β-galactosidase positive after injection of the lacZ gene under the control of the chicken β-actin promoter and the cytomegalovirus enhancer. The transduced gene was preferentially expressed in type IIA and IIX fibers, which were richer in oxidative enzymes than type IIB fibers.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s004010050888
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