ISSN:
1432-0584
Keywords:
t (8,21) AML
;
Granulocytic sarcoma CD56
;
Adhesion molecule
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract A 49-year-old man with t(8; 21) acute myeloid leukemia relapsed 8 months after successful induction chemotherapy with a paraspinal granulocytic sarcoma. There was no evidence of leukemia in the bone marrow at relapse. At initial presentation, the blasts coexpressed CD 15, CD 33, CD 34, CD 45, CD 19, and CD 56 (a neural cell-adhesion molecule). Expression of certain cell-adhesion molecules on leukemic blasts may determine a tendency to develop extramedullary relapse. The co-expression of CD 56 may have a role in the predisposition of t(8; 21) AML to develop GS.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01696563
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