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  • 1
    Electronic Resource
    Electronic Resource
    Primary aldosteronism with bilateral adrenal adenomas (1980)
    Springer
    Virchows Archiv 388 (1980), S. 229-236 
    Details
    ISSN: 1432-2307
    Keywords: Primary aldosteronism ; Computerized tomography ; Adrenal cortex neoplasms ; Spironolactone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An unusual case of primary aldosteronism with bilateral single adenomas is reported. The two tumors were revealed by computerized axial tomography and subsequently confirmed by surgical exploration. Spironolactone therapy prior to the operation induced the formation of spironolactone bodies in only one of the two adenomas. As it has been postulated that these cytoplasmic inclusions may reflect the activity of the adenomatous cells, the presence of the bodies in a single adenoma would indicate a unilateral source of the hyperaldosteronism. Thus, the existence of spironolactone bodies could corroborate the data of functional localizing tests more closely than the morphological findings of computerized tomography.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00430691
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Multiple types of Ca2+ channels in visceral smooth muscle cells (1991)
    Springer
    Pflügers Archiv 418 (1991), S. 144-152 
    Details
    ISSN: 1432-2013
    Keywords: Patch clamp ; Bufo marinus ; Dihydropyridine ; Bay K 8644
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Single-channel currents were recorded from two classes of Ca2+ channels in visceral smooth muscle cells isolated from the stomach of the toad, Bufo marinus: a class of small-conductance channels (approximately 11 pS) and a class of large-conductance channels (approximately 26 pS). Small-conductance channels were present in a majority of patches and gave rise to a slowly inactivating current (t1/2 ≈ 250 ms at 0 mV). Openings of large-conductance channels could be unequivocally resolved only in the presence of the dihydropyridine Ca2+ agonist Bay K 8644. Two subtypes of the large-conductance channels were found — those with a very slow rate of decay (〉 500 ms) and those with a faster one (〈 100ms). Large-conductance channels resemble L-type Ca2+ channels of other preparations. Small-conductance channels do not fit unambiguously into the other existing categories (i.e., N or T). Correspondence between single-channel and macroscopic Ca2+ currents is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00370463
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    Paper (German National Licenses)
    Fulltext
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