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  • Neuropeptide Y  (2)
  • Adrenergic mechanisms  (1)
  • Engineering General  (1)
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  • 1
    ISSN: 0167-0115
    Keywords: Nasal mucosa ; Neuropeptide Y ; Noradrenaline ; Peptide histidine isoleucine ; Pig ; Somatostatin ; Vascular control ; Vasoactive Intestinal Polypeptide
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0167-0115
    Keywords: Conformational entropy ; Ligand-receptor interaction ; Molecular dynamics ; Molecular modeling ; Neuropeptide Y ; Pig spleen
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European archives of oto-rhino-laryngology and head & neck 252 (1995), S. 298-303 
    ISSN: 1434-4726
    Keywords: Nasal mucosa ; Adrenergic mechanisms ; β2-agonist ; β3agonist ; Propranolol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In thiopentone-anesthetized mature pigs (n = 7), local intra-arterial infusion of the β2-adrenoceptor agonists terbutaline and salbutamol and the β3-agonist BRL 37344 induced dose-dependent increases in nasal arterial blood flow (BF) and volume of the nasal mucosa (reflecting capacitance vessel function). Increases were also found in the laser Doppler flowmeter signal, reflecting superficial mucosal BE. In contrast to terbutaline and salbutamol, BRL 37344 showed marked effects on volume. Pretreatment with the β-adrenoceptor blocker propranolol significantly reduced the vasodilatory effects of terbutaline and salbutamol, whereas the BF increase evoked by BRL 37344 was not affected. Exogenous noradrenaline (NA) induced in vitro dose-dependent contractions of human nasal mucosa biopsies obtained from patients with non-allergic chronic rhinitis (n = 21) or non-allergic nasal polyposis (NANP, n = 16). On a molar basis, the contractile effect of NA was significantly greater in nasal mucosa samples without histological abnormalities when compared to biopsies with abundant inflammatory cells and edema within the submucosa. In the presence of propranolol, the vasoconstrictor effect of NA was significantly enhanced in biopsies with abundant inflammatory cells obtained from patients with NANP (P〈0.01). This observation suggests the possible occurrence of a β2 hyper-reactivity in the nasal mucosa of patients with NANP. After precontraction in a Krebs-Ringer solution with 50 nM K+, all nasal biopsies studied showed dose-dependent relaxation to terbutaline, salbutamol and BRL 37344. This relaxant effect was markedly reduced after pretreatment with propranolol. These observations suggest that β2- and β3-adrenergic vasodilatatory mechanisms may be similar in the nasal mucosa of the pig and man.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    International Journal for Numerical and Analytical Methods in Geomechanics 11 (1987), S. 381-390 
    ISSN: 0363-9061
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Architecture, Civil Engineering, Surveying , Geosciences
    Notes: Hydraulic and mechanical properties of rock masses are largely dependent upon the distribution and variation of fracture areas. Consequently, it is essential to develop good models for analysing the spatial geometric characteristics of fracture fields. The latter, however, may be ascertained only by measuring open cuts or boreholes. The most important factor from the analysis of areas is to be able to determine spatial networks. Without an exhaustive and expensive inventory, the classical methods involving measurements of dip and strike do not provide either a correct estimation of fracture orientations in space, or a good estimation of their distribution.At present, automatic analysis of linear traces on large plane areas is used by several authors1,2 and the field strike and dip measurements are applied only for verification purposes. This method of computing spatial networks is especially suitable because of the nature of data so obtained, since it permits various simulations on computed networks. It is based upon classical methods of vector geometry that involve a measurements data matrix and provide a means of solving a double system of equations. Results are the directional spatial fracture densities. The object of this paper is to define the geometric parameters of this problem and the computation method, to present an example and, finally, to conclude with critical comments supported by certain proposals for a variety of applications.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
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