Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 70 (1992), S. 637-657 
    ISSN: 1432-1440
    Keywords: Pulmonary surfactant ; Phospholipids ; Surfactant proteins ; Alveolar stability ; Air pollution ; Pulmonary defense ; Adult respiratory distress syndrome ; Surfactant therapy ; Bronchoalveolar lavage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Pulmonary surfactant is synthesized and secreted by alveolar type II cells and constitutes an important component of the alveolar lining fluid. It comprises a unique mixture of phospholipids and surfactant-specific proteins. More than 30 years after its first biochemical characterization, knowledge of the composition and functions of the surfactant complex has grown considerably. Its classically known role is to decrease surface tension in alveolar air spaces to a degree that facilitates adequate ventilation of the peripheral lung. More recently, other important surfactant functions have come into view. Probably most notable among these, surfactant has been demonstrated to enhance local pulmonary defense mechanisms and to modulate immune responses in the alveolar milieu. These findings have prompted interest in the role and the possible alterations of the surfactant system in a variety of lung diseases and in environmental impacts on the lung. However, only a limited number of studies investigating surfactant changes in human lung disease have hitherto been published. Preliminary results suggest that surfactant analyses, e.g., from bronchoalveolar lavage fluids, may reveal quantitative and qualitative abnormalities of the surfactant system in human lung disorders. It is hypothesized that in the future, surfactant studies may become one of our clinical tools to evaluate the activity and severity of peripheral lung diseases. In certain disorders they may also gain diagnostic significance. Further clinical studies will be necessary to investigate the potential therapeutic benefits of surfactant substitution and the usefulness of pharmacologic manipulation of the secretory activity of alveolar type II cells in pulmonary medicine.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1432-1750
    Keywords: Chronic Cor pulmonale ; Hemodynamics ; Radiology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 278 Pat. mit chronischem Cor pulmonale und 44 Kontrollpersonen wurde die Beziehung zwischen linearen Herzmaßen und dem Mitteldruck in der A. pulmonalis untersucht. Das Ergebnis der Berechnungen zeigt, daß allein aufgrund der Breite des Pulmonalsegments bzw. nach dem Querschnitt des R. intermedius der rechten A. pulmonalis eine Schätzung des Pulmonalisdrucks möglich ist. Die Genauigkeit der Vorhersage wird jedoch besser, wenn zusätzlich der Transversaldurchmesser und der Breitendurchmesser des Herzens zur Schätzung herangezogen werden. Im Bereich normaler und leicht bis mäßig erhöhter Pulmonalisdrücke besteht eine Tendenz zur Überschätzung, während die Vorhersage bei stark erhöhten Drücken oft zu niedrige Werte erwarten lassen würde. Durch eine Fehleinschätzung aufgrund der Röntgenmaße entsteht kein klinisch relevanter Irrtum, da bei pathologischen Drücken kaum falsch negative Beurteilungen vorkommen. Nach diesen Befunden ist in der Regel auch bei leichter pulmonaler Hypertonie aufgrund der Röntgenkriterien eine Verdachtsdiagnose möglich.
    Notes: Abstract 278 patients with chronic cor pulmonale caused by obstructive bronchitis or by primary pulmonary hypertension and a controlgroup of 44 patients were examined for mean pulmonary pressures and linear dimensions of heart and major lung vessels taken from roentgenograms. A significant correlation was found between these 2 parameters, indicating the possibility of estimating pulmonary arterial pressure by measuring only the width of the pulmonary segment or the cross-section of the ramus intermedius of the right pulmonary artery. Prediction of pulmonary pressure was most accurate when all measurable diameters of the heart were used for evaluation. With this method, overestimation of pulmonary pressure values was found more often for normal or only slightly elevated them for high pressure ranges, where a tendency to underestimation was noted. There were few false-normal predictions for actually elevated pressures. According to our results it usually on the basis of roentgenologic signs is possible to detect even mild pulmonary hypertension.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...