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  • 1
    Electronic Resource
    Electronic Resource
    Localization of thromboxane synthase in human tissues by monoclonal antibody Tü 300 (1992)
    Springer
    Virchows Archiv 421 (1992), S. 249-254 
    Details
    ISSN: 1432-2307
    Keywords: Thromboxane ; Thromboxane synthase ; Immunohistochemistry ; Mononuclear phagocyte system ; Epithelia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using the monoclonal antibody Tü 300 we localized thromboxane synthase, a secondary enzyme of the arachidonic acid cascade, employing the alkaline phosphatase anti-alkaline phosphatase method and indirect double labelling immunofluorescence in frozen sections of human tissues. Aside from platelets, the source of the antigen, all cells of the mononuclear phagocytic system were positive, including epithelioid cells and associated giant cells, starry sky macrophages, dendritic cells of T-cell areas, Langerhans cells and Kupffer cells. In addition, some epithelial cells such as epithelia of tonsillar crypts, reticular epithelia of the thymic cortex and ductular epithelia in liver, pancreas, female breast and salivary glands showed occasional focal reactivity for thromboxane synthase. We suggest that the mAb Tü 300 is a key marker for the macrophage system and the thromboxane generating system in normal and pathological conditions. It may detect functional activities of as yet unknown significance in some specialized epithelial cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01611182
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The localization of thromboxane synthase in normal and pathological human kidney tissue using a monoclonal antibody Tü 300 (1994)
    Springer
    Virchows Archiv 424 (1994), S. 69-74 
    Details
    ISSN: 1432-2307
    Keywords: Kidney ; Thromboxane ; Thromboxane synthase ; Tü 300 monoclonal antibody
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Thromboxane, excreted in the urine in increased amounts in glomerular, vascular and tubulo-interstitial diseases, is considered to originate from the kidney. The localization of thromboxane synthase, a key enzyme of arachidonic acid metabolism, was studied in the human kidney by immunohistology using the monoclonal antibody Tü 300. In the interstitial tissue dendritic reticulum cells surrounding the tubules expressed high concentrations of the enzyme. In glomeruli the enzyme was weakly expressed in podocytes. This was confirmed by co-localization with an antiserum directed to podocalyxin, a marker of the visceral epithelial cells. In the study of various kidney diseases, massive accumulation of thromboxane synthase containing cells was observed in interstitial diseases, whereas in glomerular diseases there were no differences from normal kidney; in a case of thrombotic microangiopathy podocytes exhibited an increase in thromboxane-synthase. The thromboxane-synthase positive infiltrating interstitial cells were shown by conventional light microscopy to be mononuclear phagocytic cells. The physiological sources of renal thromboxane are dendritic reticular cells and podocytes. In interstitial renal disease infiltrating cells of the monocyte/macrophage system constitute the major site of thromboxane synthesis. In glomerular disease, a characteristic alteration of thromboxane-synthase was not found.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00197395
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Das Normgewicht des Gehirns beim Erwachsenen in Abhängigkeit von Alter, Geschlecht, Körpergröße und Gewicht (1994)
    Springer
    Der Pathologe 15 (1994), S. 165-170 
    Details
    ISSN: 1432-1963
    Keywords: Schlüsselwörter Normales Hirngewicht ; Erwachsene ; Alter ; Geschlecht ; Körpergröße ; Gewicht ; Key words Normal brain weight ; Adults ; Age ; Sex ; Height ; Weight
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Based on more than 8000 autopsies of male and female patients without brain diseases the normal brain weight of adult males and females in relation to sex, age, body-weight, and body-height as well as Body Mass Index were calculated. The average brain weight of the adult male was 1336 gr; for the adult female 1198 gr. With increasing age, brain weight decreases by 2.7 gr in males, and by 2.2 gr in females per year. Per centimeter body height brain weight increases independent of sex by an average of about 3.7 gr. Body Mass Index is of minor importance and only relevant in males. Based on these data the independent variables, age and height, were for the first time combined in a nomogram for the calculation of brain weight. The mathematical functions were integrated in a computer program which facilitates the calculation of normal brain weights in individual cases.
    Notes: Zusammenfassung Anhand von über 8000 Autopsien von Patienten ohne Hirnkrankheiten wurden die Normgewichte der Gehirne für Männer und Frauen in Abhängigkeit von Alter, Körpergröße, Gewicht und Body Mass Index berechnet. Das Hirngewicht des erwachsenen Mannes beträgt im Durchschnitt 1336 g, das der erwachsenen Frau 1198 g. Pro Altersjahr nimmt das Hirngewicht beim Mann um ca. 2,7 g, bei der Frau um ca. 2,2 g ab. Pro cm Körpergröße nimmt das Hirngewicht bei beiden Geschlechtern um ca. 3,7 g zu. Den geringsten Einfluß auf das Hirngewicht hat der Body Mass Index, der praktisch nur bei Männern bedeutsam ist. Aus den unabhängigen Variablen, Alter und Körpergröße, wurde erstmals ein Nomogramm für das zu erwartende Hirngewicht konstruiert. Gleichzeitig wurden die Funktionen unter Berücksichtigung der wichtigsten Einflußgrößen in ein Computerprogramm integriert, das die Normgewichte errechnet und quantitative Aussagen über die Abweichung des Hirngewichts von der Norm im Einzelfall erlaubt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002920050040
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    Paper (German National Licenses)
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