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  • Chemistry  (7)
  • Adverse events; postoperative  (1)
  • C2B8  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Adverse events with continuous doxapram infusion against late postoperative hypoxaemia (1996)
    Springer
    European journal of clinical pharmacology 50 (1996), S. 191-194 
    Details
    ISSN: 1432-1041
    Keywords: Key words Doxapram infusion ; Hypoxaemia ; Adverse events; postoperative ; randomized ; double-blind ; controlled study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: A randomized double-blind controlled trial of doxapram versus placebo against late postoperative hypoxaemia was planned to include 40 patients (2 × 20). Results: After inclusion of 18 patients a serious adverse event was encountered with development of a brain stem infarction in a 90-year-old woman receiving doxapram. At this point the randomization code was broken and we decided to terminate the trial. Three of nine patients receiving doxapram had had an adverse event whereas none of the patients receiving placebo had adverse events (P = 0.2). In the 18 patients studied, there was an insignificant trend towards higher mean oxygen saturation in the doxapram group, and a significantly higher minimum oxygen saturation and reduced number of hypoxaemic events on the first postoperative night. Conclusion: Although these preliminary data on the effect of doxapram on postoperative hypoxaemia seem promising, further studies on the effect of continuous nocturnal postoperative doxapram infusion on levels of arterial oxygen saturation should be postponed until more knowledge about the pharmacokinetics of doxapram in this particular clinical situation has been gathered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002280050091
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  • 2
    Electronic Resource
    Electronic Resource
    Association of serum Rituximab (IDEC–C2B8) concentration and anti-tumor response in the treatment of recurrent low-grade or follicular non-Hodgkin's lymphoma (1998)
    Springer
    Annals of oncology 9 (1998), S. 995-1001 
    Details
    ISSN: 1569-8041
    Keywords: C2B8 ; follicular lymphoma ; IDEC ; immunotherapy ; low grade ; MABTHERA ; monoclonal antibody ; Rituxan
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Monoclonal antibodies are being utilized for treatment of patients with low-grade non-Hodgkin's lymphoma as well as other cancers. Results from phase I and II clinical studies has shown that the chimeric monoclonal antibody Rituximab has minimal toxicity and significant therapeutic activity in low grade non-Hodgkin's lymphoma. Patients and methods: We have recently reported on a multicentre pivotal phase III clinical trial involving 166 patients with recurrent low-grade lymphoma who were treated with four infusions of Rituximab. Eighty patients (48%) achieved objective responses including 10 patients (6%) with complete responses. Overall, 126 patients (76%) had a ≥20% reduction in overall tumor size. The median response duration and time to progression are 11.6 and 13.2 months, respectively. The infusional and long term toxicities were limited. Results: In this report we describe the pharmacokinetic data obtained on these patients. Measurable concentrations of Rituximab were detected in all patients after the first infusion and increased throughout the treatment course. The half-life of the monoclonal antibody increased from 76.3 hours after the first infusion to 205.8 hours after the fourth infusion and was concomitant with a four-fold decrease in the antibody clearance. At three months and six months post-treatment, the median Rituximab serum levels were 20.3 µg/ml (range 0.0 to 96.8 µg/ml in 104 patients) and 1.3 µg/ml (range 0.0–28.7 µg/ml in 13 patients), respectively. A statistically significant correlation was found between the median antibody concentration and response for multiple time points during the treatment and followup. The mean serum antibody concentration was also inversely correlated with measurements of tumor bulk and with the number of circulating B cells at baseline. Conclusions: We conclude that Rituximab is therapeutically effective against B-cell lymphoma. Pharmacokinetic data suggests that certain subsets of patients may possibly benefit from increased dosing and studies to address this are currently underway.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008416911099
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  • 3
    Electronic Resource
    Electronic Resource
    Über Sublimationsversuche mit Kohlenhydraten (1922)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 5 (1922), S. 575-576 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19220050419
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  • 4
    Electronic Resource
    Electronic Resource
    Über Küpenfarbstoffe (1909)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 22 (1909), S. 2129-2131 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19090224402
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  • 5
    Electronic Resource
    Electronic Resource
    Neuerungen auf dem Thioindigorot-gebiet (1908)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 21 (1908), S. 961-970 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19080212002
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  • 6
    Electronic Resource
    Electronic Resource
    Ueber Abkömmlinge und Umsetzungen der gebromten Thiophene (1885)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 18 (1885), S. 3027-3031 
    Details
    ISSN: 0365-9496
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.188501802240
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  • 7
    Electronic Resource
    Electronic Resource
    Ueber das Trichlorthiophen und einige Derivate desselben (1886)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 19 (1886), S. 650-652 
    Details
    ISSN: 0365-9496
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.188601901147
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  • 8
    Electronic Resource
    Electronic Resource
    Ueber die Anhydride der aromatischen Sulfosäuren (1886)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 19 (1886), S. 652-655 
    Details
    ISSN: 0365-9496
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.188601901148
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  • 9
    Electronic Resource
    Electronic Resource
    Ueber die Lutidine des Steinkohlentheers (1887)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 20 (1887), S. 127-137 
    Details
    ISSN: 0365-9496
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.18870200132
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