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  • 1
    Electronic Resource
    Electronic Resource
    Spatial organization of olfactory receptor neurons on the antenna of the cabbage looper moth (1998)
    Springer
    Journal of comparative physiology 183 (1998), S. 433-442 
    Details
    ISSN: 1432-1351
    Keywords: Key words Electrophysiology ; Noctuidae ; Pheromone ; Single-cell ; Sensilla trichodea
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Electrophysiological responses to stimulation with behaviorally relevant compounds were recorded from receptor neurons within specialized classes of sensilla on the antennae of male cabbage looper moths. Receptor neurons were found that specifically respond to stimulation with Z-7,12:AC, Z-7,14:AC, Z-9,14:AC, and Z-7,12:OH. Specialized receptor neurons were not found for the three remaining pheromone blend components, 12:AC, Z-5,12:AC, or 11,12:AC. However, a new class of sensillum containing a pair of neurons insensitive to all of the cabbage looper pheromone components was encountered. In addition, spatial patterns of distribution along the flagellum for identified classes of sensilla are described. Sensilla containing Z-7,12:AC-sensitive neurons are preferentially located on the proximal half of the antennal flagellum. In addition to this distribution along the length of the antenna, a pattern across individual flagellar subsegments is described. Sensilla containing neurons sensitive to Z-9,14:AC were found exclusively on the lateral margins of individual flagellar subsegments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003590050269
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The influence of molecular structure on the affinity and efficacy of some β-adrenoceptor agonists (1985)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 331 (1985), S. 240-246 
    Details
    ISSN: 1432-1912
    Keywords: Affinity ; Efficacy ; β1-/β2-Adrenoceptors ; Agonists ; Antagonists
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The affinity and efficacy of a number of sympathomimetic amines structurally related to prenalterol and the selective β1-adrenoceptor agonist RO 363 were determined using a combination of radioligand binding and organ bath techniques. Affinity of the molecules (pK D) was calculated from their ability to displace the radioligand [125I]iodocyanopindolol ([125I]CYP) from β-adrenoceptor sites in left atrial (β1) and uterine (β2) membrane homogenates. These pK D values were used to calculate efficacy from the positive inotropic and uterine relaxant responses elicited by the drugs in organ bath experiments. The drugs studied were either arylethanolamines i.e., (−)-isoprenaline (ISO), p-hydroxyisoprenaline (pOH-ISO), compounds XIV and XVI or aryloxypropanolamine-derivatives, i.e., oxymethylene-isoprenaline (OM-ISO), prenalterol and Compound XI which possessed ap-phenol or catechol ring and an isopropyl or a homoveratryl amine substituent. Only ISO, OM-ISO, pOH-ISO and Compound XVI were active as agonists in both tissue preparations. These drugs were partial agonists which exhibited a wide range of pD2 values and did not display any marked selectivity for either β-adrenoceptor subtype. Compound XI and prenalterol were inactive as agonists and together with the partial agonists behaved as competitive antagonists to ISO in the two preparations. All drugs tested displaced [125I]CYP from β-adrenoceptor sites, however, there was also a wide range of potency amongst the drugs. Analysis of the structure-affinity and structure-efficacy relationships indicated that removal of the 3-hydroxyl group from the catechol ring reduces both affinity and efficacy without altering the selectivity of the drug for either β-adrenoceptor subtype. While aryloxypropanolamine derivatives have generally higher affinities than arylethanol-amines, especially at β-adrenoceptor sites, their efficacies are generally reduced at both β-adrenoceptors. The presence of a homoveratryl group in aryloxypropanolamines enhances slightly the affinity for β1- and reduces affinity for β2-adrenoceptors. With this amine group, efficacy is markedly reduced at β2- as opposed to β2-adrenoceptor sites. Thus for prenalterol, the small degree of cardioselectivity can be attributed to the oxymethylene group whilst its lack of agonist activity (i.e., efficacy) reflects a combined action of this group and the absence of the 3-hydroxyl group on the phenyl ring. In RO363 it can be deduced that the oxymethylene group, together with the homoveratryl substituent are responsible for the observed selective affinity of the drug for β1- as opposed to β2-adrenoceptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00634244
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Quantitative comparison of behavioral and neurophysiological responses of insects to odorants (1987)
    Springer
    Journal of chemical ecology 13 (1987), S. 509-531 
    Details
    ISSN: 1573-1561
    Keywords: Pheromone ; olfaction ; electroantennogram ; neurophysiology ; Trichoplusia ni ; Heliothis zea ; Plodia interpunctella ; Lepidoptera ; Noctuidae ; Pyralidae
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract A consistent pattern of relationships emerges from comparisons of insect electroantennograms, peripheral olfactory receptor neuron responses, and behavioral responses to quantified concentrations of odorants. One consistency is that all of the different response measurements can be described by stimulus-response curves of the same form. Another is that the responses have characteristic groupings when they are plotted against odorant concentration. The pattern of relationships is exemplified in the responses ofTrichoplusia ni (Hübner),Heliothis zea (Boddie), andPlodia interpunctella (Hübner) to several pheromone components and analogs. To quantify the relevant stimulus parameters for the response comparisons, the emission rates of the stimulus delivery system were calibrated for several 12 to 17-carbon pheromone components. The stimulus-response relationships determined forT. ni, H. zea, andP. interpunctella are combined with relationships reported for other insects in the literature, and applications are discussed for the interpretation of pheromone trapping and laboratory bioassays.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01880096
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    Paper (German National Licenses)
    Fulltext
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