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  • Rat bladder carcinogenesis  (2)
  • Affinity chromatography  (1)
  • Cerebral amyloid angiopathy  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Promoting effect of sodium chloride in 2-stage urinary bladder carcinogenesis in rats initiated by N-Butyl-N-(4-hydroxybutyl)-nitrosamine (1986)
    Springer
    Urological research 14 (1986), S. 201-206 
    Details
    ISSN: 1434-0879
    Keywords: Rat bladder carcinogenesis ; Initiation and promotion ; N-Butyl-N-(4-hydroxybutyl)nitrosamine ; Urinary composition ; Sodium chloride
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The promoting effect of sodium chloride (NaCl) in 2-stage urinary bladder carcinogenesis in F344 rats initiated by 2 doses of N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) was investigated. The incidences of PN hyperplasia were significantly higher in rats initiated with 0.01 or 0.05% BBN when they were given diet containing 10% NaCl for 32 weeks than when they were given control diet. The incidence of papilloma in rats given 0.05% BBN followed by diet containing 10% or 5% NaCl tended to be higher than that in control rats. The urine of rats given diet containing NaCl was larger in volume and had lower osmolality than that of controls. The total urinary sodium and chloride contents were also increased, whereas those of potassium and phosphorus were decreased. No calculus formation or crystalluria was observed. These data suggest that excess intake of sodium as NaCl has a weak promoting effect in 2-stage urinary bladder carcinogenesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00441114
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of partial cystectomy on the induction of pre-neoplastic lesions in rat bladder initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine followed by bladder carcinogens and promoters (1982)
    Springer
    Urological research 10 (1982), S. 115-118 
    Details
    ISSN: 1434-0879
    Keywords: Rat bladder carcinogenesis ; Initiation and promotion ; Partial cystectomy ; N-butyl-N-(4-hydroxybutyl)-nitrosamine ; N-ethyl-N-(4-hydroxybutyl)nitrosamine ; Sodium saccharin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of partial cystectomy on the occurrence of pre-neoplastic lesions, papillary or nodular hyperplasia (PN hyperplasia), of the bladder in male F344 rats was studied in an experiment in which bladder carcinogens and promoters were given to the rats after initiation with BBN. The bladder carcinogens tested were N-ethyl-N-(4-hydroxybutyl)nitrosamine (EHBN) and N-4[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT) and the bladder promoters were sodium saccharin, sodium cyclamate, and DL-tryptophan. Partial cystectomy significantly decreased the occurrence of PN hyperplasia in rats treated with EHBN and tended to inhibit that in rats given saccharin or tryptophan. Thus partial cystectomy inhibited rather than enhanced the induction of PN hyperplasia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00255952
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Spinal cord vascular and leptomeningeal amyloid β-protein deposition in a case with cerebral amyloid angiopathy (1992)
    Springer
    Acta neuropathologica 84 (1992), S. 207-210 
    Details
    ISSN: 1432-0533
    Keywords: Cerebral amyloid angiopathy ; Amyloid β-protein ; Alzheimer's disease ; Spinal leptomeningeal vessels
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cerebral amyloid angiopathy (CAA) is characterized by the deposition of amyloid fibrils on leptomeningeal and cortical blood vessels, and the incidence of this disorder increases with age. However, this form of vascular amyloid deposition rarely involves tissues outside of the brain. A 71-year-old woman first developed some deterioration in memory, and soon afterwards suffered from recurrent episodes of subcortical hemorrhage. Histopathological examination of this case revealed typical pathology of Alzheimer's disease with an extensive appearance of β-protein type CAA, and additionally, the spinal leptomeningeal vessels and the pia-arachnoid membranes were also affected by amyloid β-protein deposits. The spinal cord involvement associated with CAA and Alzheimer's disease is unusual, and the present case provides additional important information on the pathogenesis of disorders with β-protein deposition including Alzheimer's disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00311397
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    High-performance liquid chromatographic assay of serum glycated albumin (1988)
    Springer
    Diabetologia 31 (1988), S. 627-631 
    Details
    ISSN: 1432-0428
    Keywords: Affinity chromatography ; anion exchange chromatography ; fructosamine ; haemoglobin A1c ; glycaemic control ; glycated protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A method for determination of serum glycated albumin by high-performance liquid chromatography is presented. The system involves anion exchange chromatography to separate albumin and consecutive boronate affinity chromatography to separate glycated and nonglycated albumin. The method is rapid (20 min), precise (coefficient of variation, 0.7–4.9%), requires only a small sample (5 μl), and can be automated. Assay of glycated albumin by this method is not influenced by the protein concentration of the sample or the presence of glucose. The variation in glycated albumin values in consecutive samples obtained within a day from diabetic patients (coefficient of variation, 2.02±0.65%) was significantly smaller (p〈0.001) than that of values for fructosamine (coefficient of variation, 4.33±2.0%). The values of glycated albumin in normal subjects (20.2±1.6%) were clearly less than those in diabetic patients [39,6±5.4% in 40 Type 1 (insulin-dependent) and 39.4±5.9% in 25 Type 2 (non-insulin-dependent) patients]. The serum glycated albumin level was well correlated with HbA1c in 65 diabetic patients (r=0.60). Because the life span of albumin in the circulation is short, measurement of glycated albumin should be useful as a short-term index of glycaemic control.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00264772
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    Paper (German National Licenses)
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