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  • Polymer and Materials Science  (2)
  • Affinity for Oxygen and Carbon Monoxide  (1)
  • Antriebssystem  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Qualitative Änderungen in Lebermikrosomen Phenobarbital-behandelter Kaninchen (1970)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 267 (1970), S. 307-326 
    Details
    ISSN: 1432-1912
    Keywords: Enzyme Induction ; Microsomal Enzymes ; Michaelis Constants ; Spectral Dissociation Constants ; Affinity for Oxygen and Carbon Monoxide ; Schlüsselwörter ; Enzyminduktion ; Mikrosomale Enzyme ; Michaelis-Konstanten ; Spektrale Dissoziationskonstanten ; Sauerstoff- und Kohlenmonoxid-AffinitÄt
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Phenobarbital treatment of rabbits was found to cause significant changes in some of the apparent Michaelis (K M) constants for p- and N-hydroxylation of aniline [reactions 1 and 2, resp.] and de-ethylation, p- and N-hydroxylation of N-ethylaniline [reactions 3,4, and 5, resp.], and in the spectral dissociation constants (K s) for aniline, N-ethylaniline and ethylisocyanide in isolated hepatic microsomes. The “critical” oxygen concentrations were increased in all reactions investigated. The distribution constants (K G) for CO, determined according to Warburg, decreased in the reactions 2, 3, and 4, and increased in reaction 1. Reaction 5 was not inhibited by CO in microsomes from untreated rabbits and was stimulated by CO after phenobarbital treatment of the animals. Depending on the reaction, theK M-values for aniline and N-ethylaniline were increased, decreased, or remained unchanged by the phenobarbital treatment of the animals. The most striking changes inK M-values were observed with the reactions 2 and 5 in which cytochrome P-450 is either not involved or is not a limiting factor. TheK s-value for ethylisocyanide measured after addition of dithionite to microsomes was increased. The correspondingK s-value measured without dithionite under aerobic conditions remained unchanged. TheK s value for aniline was decreased by the phenobarbital treatment of the animals. Using microsomes from untreated animals theK s value for N-ethylaniline could not be determined exactly. The order of magnitude of this value, however, was greater than that of the corresponding value from phenobarbital-treated animals. The observed alterations in affinity imply that induction by phenobarbital may be associated withqualitative as well as quantitative changes in the hepatic microsomal enzymes or membranes. The qualitative changes could be important for the accessibility of the reacting groups and/or substrate guiding.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00999545
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    305. Erste Erfahrungen mit dem Rostocker künstlichen Herz (1981)
    Springer
    Langenbeck's archives of surgery 355 (1981), S. 649-649 
    Details
    ISSN: 1435-2451
    Keywords: Biomaterials ; Fit trials ; Surgical technique ; Driving system ; Biomaterialien ; Anpassungsversuche ; chirurgische Technik ; Antriebssystem
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Das Programm des Rostocker künstlichen Herzens (TAH) konzentriert sich hauptsächlich auf folgende Probleme: Biomaterialien und mechanische Eigenschaften und Anpassung und Formgebung des TAH für den zukünftigen Einsatz am Menschen. Die Brauchbarkeit des TAH wurde tierexperimentell überprüft, wobei die chirurgische Technik von der Arbeitsgruppe in Utah (USA) übernommen wurde. Bei Anpassungsversuchen an 23 Verstorbenen wurden verschiedene Herztypen und ihre unterschiedliche Lokalisation überprüft.
    Notes: Summary The Rostock Total Artificial Heart (TAH) programme concentrates its main efforts on the following topics: biomaterials and mechanical properties, special problems of the driving systems, and adaptation and fit trials for human applications. The efficiency of the Rostock TAH was studied in animal experiments using the surgical technique described by the Utah group (USA). Using 23 adult human cadavers, fit trials of the different sizes and tvoes of the TAH were performed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01287139
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Im Körper gebrochene Knochenplatten  -  Schadenanalyse und Biomechanik (1977)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 8 (1977), S. 78-82 
    Details
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Osteotomy Plates which Failed in Vino  -  Failure Examination and Biomechanics.Two fractured bone plates, which were used in a subtrochanteric osteotomy, have been examinated. The fatigue failure and additional fracture-characteristics are easily to understand in regarding the stresses, acting in the plates. An evaluation shows, that such a plate should never bear any part of the body weight but should be used only for fracture-fixation.
    Notes: Zwei gebrochene Knochenplatten, die zur Versorgung von subtrochanteren Oberschenkelbrüchen eingesetzt waren, wurden untersucht. Die festgestellten Dauerbrüche und weitere Einzelheiten der Schadensfälle lassen sich zwanglos durch die Art der Belastung der Platten im Körper erklären. Eine Abschätzung der Spannungen in den Platten zeigt, daß sie lediglich eine frakturstabilisierende Funktion übernehmen können und keinesfalls einer Belastung durch das Körpergewicht ausgesetzt werden dürfen.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mawe.19770080305
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Histological and ultrastructural appearance of the hydroxyapatite-bone interface (1990)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 24 (1990), S. 829-845 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: This article describes the histological and ultrastructural appearance of the interface created in the implantation bed, between bone tissue and implants made of dense sintered hydroxyapatite (HA). Biopsies from dog subjects included: (a) loaded permucosal dental implants for tooth substitution, (b) subperiosteally placed implants for alveolar bone correction, (c) endosseously placed dental root implants to retain ridge form following extraction. The light and electron microscopical results show extensive bone apposition on the osseous sides of the implant surfaces. There is an intimate, direct bone contact without any visible interruption. The bone is of normal lamellar type and continuously connected with the trabecular bone. Bone has grown into the finest surface irregularities of the implant. Collagen fibers of the calcified bone matrix are observed within a distance less than 500 Å from the implant surface. The thin (20-100 Å) electron dense layer at the bone-implant interface resembled the lamina limitans of organic bone matrix, also seen at the inner walls of the osteocytes lacunes. Deposition of bone gives rise to a biologically stable bone-implant interface, without disturbance of the physiological bone turnover. This is seen as very favorable for desired long term fixation of implant to bone.
    Additional Material: 17 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820240704
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    Paper (German National Licenses)
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