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  • Affinity labelling  (1)
  • C57BL/6, DBA/2 and CXBK mouse strains  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Opioids and behavior: genetic aspects (1988)
    Springer
    Cellular and molecular life sciences 44 (1988), S. 473-481 
    Details
    ISSN: 1420-9071
    Keywords: C57BL/6, DBA/2 and CXBK mouse strains ; genetically obese rodents ; opioid receptors ; opioid ligands ; food intake ; analgesia ; locomotor activity ; learning and memory ; social stress ; addiction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Three animal models, based on genetic differences in endogenous opioid peptides and opioid receptors, are described. Obese mice and rats, whose pituitary opioid content is elevated, may be used to investigate eating disorders. Recombinant inbred strains of mice, which differ in brain opioid receptors and analgesic responsiveness, can be used for study of opioid-and nonopioid-mediated mechanisms of pain inhibition. Individual reactivity to opioids can be examined in C57BL/6 and DBA/2 inbred strains of mice. A model that combines a variety of opioid effects is offered and suggests the existence of a genetically determined dissociation of opioid effects on locomotor activity and pain inhibition. In addition, stimulatory locomotor responses in the C57BL/6 reaction type are linked to a high risk of drug addiction and facilitatory effects on adaptive processes, while high analgesic potency in the DBA/2 reaction type is accompanied by a low proneness to drug abuse and amnesic properties of opioids.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01958921
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of p-nitrophenyl diazonium fluoroborate on cholinergic mechanisms (1976)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 294 (1976), S. 61-68 
    Details
    ISSN: 1432-1912
    Keywords: p-Nitrophenyl diazonium fluoroborate ; Cholinergic neurons ; Acetylcholine receptor ; Acetylcholinesterase ; Affinity labelling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Electrophysiological experiments were done to investigate the effect of p-nitrophenyl diazonium fluoroborate (p-NPD) on motor endplates of the frog's m. cutaneus pectoris. The compound has no direct depolarizing effect on the postsynaptic membrane and stabilizes it irreversibly when added to the bath. Longtime iontophoretical applications of p-NPD produce a biphasic effect: initially a potentiation of the depolarizations due to acetylcholine (ACh) (both iontophoretically applied and presynaptically liberated), and subsequently an inhibition of the response to ACh. When the acetylcholinesterase (AChE) is inactivated previously, only the inhibiting effect of the compound is demonstrable. The association constant of p-NPD to purified AChE and to membrane fragments of electroplax was determined by biochemical methods. The compound's affinity to the AChE was found to be about 20 times greater than to the acetylcholine receptor (AChR). Iontophoretical application of p-NPD to cholinergic neurons in the hippocampal cortex of the cat also produced the characteristic biphasic effect on ACh-induced activity of these investigated neurons. The results suggest that the biphasic effect depends on the capacity of p-NPD to combine with both the AChE and the AChR. The AChE is first inhibited with low concentrations thereby potentiating the ACh response. At higher concentrations the AChR's are progressively inhibited too, thereby diminishing the excitability of the postsynaptic membrane up to a complete block.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00692785
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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