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  • High-Energy Phosphates  (3)
  • Nuclear Reactions  (3)
  • Age determination  (1)
  • Cerebral Metabolism  (1)
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Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Low-energy photon scattering off ^1^4^2^,^1^4^6^,^1^4^8^,^1^5^0Nd: An investigation in the mass region of a nuclear shape transition
    Amsterdam : Elsevier
    Nuclear Physics, Section A 509 (1990), S. 587-604 
    Details
    ISSN: 0375-9474
    Keywords: Nuclear Reactions
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0375-9474(90)90092-Z
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Ground state dipole transitions in ^5^8Ni
    Amsterdam : Elsevier
    Nuclear Physics, Section A 372 (1981), S. 1-12 
    Details
    ISSN: 0375-9474
    Keywords: Nuclear Reactions
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0375-9474(81)90082-8
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Distribution of orbital magnetic dipole strength in ^1^5^6Gd
    Amsterdam : Elsevier
    Nuclear Physics, Section A 458 (1986), S. 205-216 
    Details
    ISSN: 0375-9474
    Keywords: Nuclear Reactions
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0375-9474(86)90352-0
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Comparative study of the effects of chloral hydrate and trichloroethanol on cerebral metabolism (1973)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 277 (1973), S. 323-332 
    Details
    ISSN: 1432-1912
    Keywords: Chloral Hydrate ; Trichloroethanol ; Isolated Perfused Rat Brain ; High-Energy Phosphates ; Glycolytic Pathway
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The isolated perfused rat brain was used for a comparative study of the effects of chloral hydrate and trichloroethanol on cerebral energy metabolism. After a perfusion period of 30 min the brain levels of the following substrates and metabolites were measured spectrophotometrically: P-creatine, creatine, ATP, ADP, AMP, glycogen, glucose, glucose-6-P, fructose diphosphate, α-glycero-P, dihydroxyacetone-P, pyruvate, lactate, glutamate, α-ketoglutarate and ammonia. Furthermore, the concentration of chloral hydrate and trichloroethanol in the isolated brain and in the perfusion medium was measured colorimetrically. Little more than 10% of chloral hydrate in the isolated brain and in the perfusion medium were reduced to trichloroethanol. In intact animals there were about 70% of chloral hydrate transformed. Chloral hydrate and trichloroethanol caused an accumulation of P-creatine, no change in the lactate/pyruvate ratio, an increase of the glucose concentration and a decrease of glucose-6-P level in the isolated brain. The rise of brain glucose level was more pronounced after trichloroethanol than after chloral hydrate. The effects of chloral hydrate and trichloroethanol on brain glucose and glucose-6-P levels suggest an inhibition of brain hexokinase activity by these drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00500993
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Age estimation in biopsy specimens of dentin (1995)
    Springer
    International journal of legal medicine 108 (1995), S. 135-139 
    Details
    ISSN: 1437-1596
    Keywords: Age determination ; Living persons Aspartic acid racemization ; Dentin ; Dentinal biopsy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Notes: Abstract Determination of age at death on the basis of aspartic acid racemization in dentin is one of the most reproducible and accurate methods. In Germany, age estimation by this method has so far generally not been applied to living persons, since the extraction of a tooth exclusively for age estimation when it is not medically indicated is regarded as ethically and legally problematic. The development of a biopsy technique applicable to dentin took place against this background. Testing the technique and analysis of dentinal biopsy specimens revealed that the biopsy technique is a low-risk procedure that causes only minor discomfort to the affected person. It is readily practicable and facilitates standardized specimen removal. The relationship between the extent of aspartic acid racemization in dentinal biopsy specimens and age is very close, facilitating age estimation. A prerequisite for accurate results is the performance of biopsies under strictly standardized conditions. If this is guaranteed, age determination on the basis of aspartic acid racemization in dentinal biopsy specimens appears to be superior in precision to most other methods in living persons and can be used for all age groups.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01844824
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  • 6
    Electronic Resource
    Electronic Resource
    The effects of increased glucose supply and thiopental anesthesia on energy metabolism of the isolated perfused rat brain (1975)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 289 (1975), S. 399-407 
    Details
    ISSN: 1432-1912
    Keywords: Isolated Perfused Rat Brain ; High-Energy Phosphates ; Glycolytic Pathway ; Thiopental
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of glucose concentrations in the perfusion medium ranging from 5 to 15 mM and thiopental, on cerebral energy metabolism were studied using the isolated perfused rat brain. After a perfusion time of 30 min brain levels of the following substrates and metabolites were determined: P-creatine, ATP, ADP, AMP, glycogen, glucose, glucose-6-P, fructose-6-P, pyruvate, lactate, α-ketoglytarate, glutamate, ammonia. In control experiments increasing the glucose concentration in the perfusion medium produced an increase of intracellular brain glucose concentration only, revealing a linear relationship between glucose content in brain and blood. Neither high-energy phosphates nor glycolytic intermediates were markedly affected by the changes in blood glucose. With an anesthetic dose of thiopental (0.15 mM) in the perfusion medium identical metabolic alterations occurred in all experiments: P-creatine and glucose were significantly increased whereas ADP, AMP, lactate and pyruvate were diminished. Also with thiopental brain glucose was linearly related with the glucose concentration in the perfusion medium. The calculated regression line was apparently parallel with that from control experiments; that means thiopental always caused an elevation of brain glucose by the same amount of 0.9 μmoles/g—irrespective of the initial cerebral glucose content. The results yield further evidence that glucose transport is not the rate-limiting step in glycolysis. The action of thiopental on glycolytic pathway is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00508413
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  • 7
    Electronic Resource
    Electronic Resource
    The isolated perfused rat brain as a model for studying drugs acting on the CNS (1974)
    Springer
    Psychopharmacology 35 (1974), S. 169-177 
    Details
    ISSN: 1432-2072
    Keywords: Isolated Rat Brain ; Methods ; Perfusion ; Cerebral Metabolism ; Animal EEG
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An isolated perfused brain preparation is regarded as offering some important advantages over intact animals or tissue slices for studying drug effects on the CNS. The rat is by far the most suitable laboratory animal for this technique because of low cost, ease of preparation and extensive literature available for comparative purposes. In this paper various preparation techniques and perfusion systems for an isolated rat brain are reported. Investigations are presented proving the viability of the isolated perfused rat brain for more than seven hours and its suitability for studies on cerebral metabolism. Until now this preparation has been successfully used for pharmacological investigations concerning the drug effects on cerebral energy metabolism, on the EEG and on the biogenic amines in the CNS. The results further demonstrate that the use of an isolated perfused rat brain affords the possibility of clarifying pharmacological problems which has not been possible using conventional methods. In addition, this preparation should become a very useful tool for studies on pharmacokinetics, on brain circulation or on brain oxygen consumption.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429583
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  • 8
    Electronic Resource
    Electronic Resource
    Suitability of the isolated perfused rat brain for studying effects on cerebral metabolism (1972)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 275 (1972), S. 124-134 
    Details
    ISSN: 1432-1912
    Keywords: Isolated Perfused Rat Brain ; High-Energy Phosphates ; Glycolytic Pathway ; Phenobarbital ; Ischemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The concentrations of P-creatine, creatine, ATP, ADP, AMP, glycogen, glucose, glucose-6-P, fructose diphosphate, dihydroxyacetone-P, α-glycero-P, lactate and pyruvate were measured in the isolated perfused rat brain as well as in rat brain in vivo. Similar levels were observed in the isolated brain and in intact animals, and the values measured were in good accordance with those described in the literature. Only the pyruvate and lactate content were significantly higher in the isolated brain but the lactate/pyruvate ratio remained unchanged. An anesthetic or ischemia caused just the same effects on energy metabolism of the isolated rat brain as described for intact animals. Thus, 1.5 mM phenobarbital in the perfusion medium produced a statistically significant increase in P-creatine and glucose levels as well as a decrease of pyruvate, lactate and α-glycero-P levels. After ischemia of the isolated brain the concentrations of high-energy phosphates, glycogen, glucose, and pyruvate fell considerably concomitantly with significant accumulations of creatine, AMP, α-glycero-P and lactate. The results indicate that the isolated perfused rat brain may be a useful tool for studying cerebral metabolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00508901
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    Paper (German National Licenses)
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