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  • 1
    Electronic Resource
    Electronic Resource
    Inhibition of acid secretion of fundus of Rana pipiens with a high concentration of potassium on the secretory side
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Biomembranes 899 (1987), S. 17-24 
    Details
    ISSN: 0005-2736
    Keywords: (R. pipiens fundus) ; Acid secretion inhibition ; Electrogenic proton pump ; Membrane potential ; Proton pump ; Secretory K^+ effect
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0005-2736(87)90234-3
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  • 2
    Electronic Resource
    Electronic Resource
    Potential difference responses to secretory K^+, Cl^- and Na^+ changes in secreting and resting states of frog stomach
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Biomembranes 858 (1986), S. 301-308 
    Details
    ISSN: 0005-2736
    Keywords: (R. pipiens) ; Histamine ; Membrane potential ; Secretory Cl^- effect ; Secretory K^+ effect ; Secretory Na^+ effect
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0005-2736(86)90335-4
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  • 3
    Electronic Resource
    Electronic Resource
    Potential difference responses to secretory K^+, Na^+ and HCO"3^- changes in secreting and resting states of frog stomach in Cl^--free media
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Biomembranes 897 (1987), S. 445-452 
    Details
    ISSN: 0005-2736
    Keywords: (R. pipiens fundus) ; Cimetidine inhibition ; Histamine ; Membrane potential ; Secretory HCO"3^- effect ; Secretory K^+ effect ; Secretory Na^+ effect
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0005-2736(87)90441-X
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  • 4
    Electronic Resource
    Electronic Resource
    Changes with aging in the levels of amino acids in rat CNS structural elements II. Taurine and small neutral amino acids (1989)
    Springer
    Neurochemical research 14 (1989), S. 563-570 
    Details
    ISSN: 1573-6903
    Keywords: Aging ; taurine ; neutral amino acids ; amino acids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Taurine (Tau) and the small neutral amino acids glycine (Gly), serine (Ser), threonine (Thr), and alanine (Ala) were measured in 53 brain areas of 3- and 29-month-old male Fisher 344 rats. The ratio of highest to lowest level was 34 for Tau, 9.1 for Thr, 7.6 for Gly and Ser, and 6.5 for Ala. The heterogeneity was found in numerous areas; for example, Tau levels were more than 90 nmol/mg protein in 6 areas, and less than 20 nmol/mg protein in 10 areas. Similar heterogeneity was found with the other amino acids. The relative distribution of the small neutral amino acids showed several similarities; Tau distribution was different. With age, four amino acids decreased in 10–18 areas, and increased in only 1–3, while Thr increased in more areas than it decreased. The five amino acids of this paper, and the four of the previous paper, are among the amino acids at highest level in the brain; the sequence in their levels shows considerable regional heterogeneity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00964919
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  • 5
    Electronic Resource
    Electronic Resource
    Changes with aging in the levels of amino acids in rat CNS structural elements I. Glutamate and related amino acids (1989)
    Springer
    Neurochemical research 14 (1989), S. 555-562 
    Details
    ISSN: 1573-6903
    Keywords: Aging ; glutamate ; amino acids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Glutamate and related amino acids were determined in 53 discrete brain areas of 3-and 29-month-old male Fischer 344 rats microdissected with the punch technique. The levels of amino acids showed high regional variation-the ratio of the highest to lowest level was 9 for aspartate, 5 for glutamate, 6 for glutamine, and 21 for GABA. Several areas were found to have all four amino acids at very high or at very low level, but also some areas had some amino acids at high, others at low level. With age, in more than half of the areas, significant changes could be observed, decrease occurred 5 times more frequently than increase. Changes occurred more often in levels of aspartate and GABA than in those of glutamate or glutamine. The regional levels of glutamate and its related amino acids show severalfold variations, with the levels tending to decrease in the aged brain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00964918
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  • 6
    Electronic Resource
    Electronic Resource
    Calpain II activity and calpastatin content in brain regions of 3- and 24-month-old rats (1990)
    Springer
    Neurochemical research 15 (1990), S. 243-249 
    Details
    ISSN: 1573-6903
    Keywords: Calpain II ; Calpastatin ; Aging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In previous studies, we found a significantly higher (100% or more) content of cathepsin D in the aging brain. In the present study, we determined activity of Ca2+-activated neutral protease requiring millimolar Ca2+ (calpain II, CANP II) and amount of its endogenous inhibitor, calpastatin, in extracts of various brain regions of 3-month-old and 24-month-old male Fischer-344 rats. Calpain II was separated from calpastatin in a single step (chromatography) and its activity was tested using as substrates [methyl-14C]α-casein, the cytoskeletal proteins desmin and actin, and a mixture of neurofilament triplet proteins and glial fibrillary acidic proteins (GFAP). We found no changes in calpain II activity in pons-medulla and spinal cord, but significant increases were detected in cortex (72%) and striatum (63%) of the 24-month-old rats using [methyl-14C]α-casein as substrate. The profile of desmin and actin breakdown showed regional variations somewhat different from those of [methyl-14C]α-casein. With desmin, the greatest increases with age were in the striatum (82%) and hypothalamus (46%), but there were no alterations in cortex, cerebellum, and pons-medulla. With actin, slightly enhanced activity in cortex and cerebellum was noticeable. Calpastatin content in brain regions was also increased, with the regional pattern of increase fairly similar to the pattern of enzyme activity increase. The causes and the physiological consequences of increased calpain and calpastatin content in the aged brain are being investigated. That changes with age are some-what different with the various brain protein substrates indicates that some of the properties of the enzyme also undergo alteration with age. The change does not appear to be due to a change in distribution, since most of the enzyme, unlike its inhibitor, is in the soluble form.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00968667
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  • 7
    Electronic Resource
    Electronic Resource
    Friction properties at the bone-metal interface: Comparison of four different porous metal surfaces (1997)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 35 (1997), S. 329-336 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Detailed friction load-displacement response of four distinct metallic surfaces [one beaded porous metal (CTR) and three cast Co-Cr alloy ingrowth mesh surfaces, nonplanar mesh (INX), cast mesh 1 (CM1), and cash mesh 2 (CM2)] on polyurethane and cancellous bone specimens of six tibiae were measured under different normal stresses (0.1, 0.15, or 0.025 MPa). Bone cubes were obtained from different proximal regions of resurfaced cadaveric tibiae. Both monotonic and cyclic fatigue loadings of up to 4000 cycles at 1 Hz were considered. Comparison of measured results indicated that the friction coefficient was not affected by the magnitude of normal stress and the bone excision site (medial, lateral, anterior, posterior, and central). The CM2 surface showed significantly greater resistance with friction coefficients of more than 0.9 for the bone and 0.8 for the polyurethane. The INX surface yielded the second largest resistance followed by CMI and CTR surfaces. No significant difference was found between these latter two surfaces. Fatigue tests up to 4000 loading-unloading cycles showed about 10% reduction in friction coefficient for CTR and INX surfaces, while negligible reduction was found for CM1 and CM2 surfaces. © 1997 John Wiley & Sons, Inc.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
  • 8
    Electronic Resource
    Electronic Resource
    Electrical properties of glucose-sensitive hydrogels: Swelling and conductivity relationships (1998)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 41 (1998), S. 65-70 
    Details
    ISSN: 0021-9304
    Keywords: swelling ; conductivity ; hydrogels ; immobilized enzymes ; responsive polymers ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: The electrical characteristics of a glucose-sensitive polymeric hydrogel have been studied. The hydrogel matrices were prepared by radical polymerization of solutions containing 2-hydroxyethyl methacrylate, N,N-dimethyl aminoethyl methacrylate, tetraethylene glycol dimethacrylate, ethylene glycol, water, and glucose oxidase. The hydrogels displayed faster and higher swelling rates for lower levels of a crosslinking agent. Electrical conductivity was found to be a sensitive measurement of the state of the swelling. A simple model that relates hydrogel swelling and conductivity has been proposed. © 1998 John Wiley & Sons, Inc. J Biomed Mater Res, 41, 65-70, 1998.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Rotational diffusion in methyl iodide: Bandshape analysis of degenerate vibrational modes (1989)
    Chichester [u.a.] : Wiley-Blackwell
    Journal of Raman Spectroscopy 20 (1989), S. 339-343 
    Details
    ISSN: 0377-0486
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The Raman spectral bandshapes of the ν1(A1), ν3(A1) and ν4(E) vibrations of CH3I were studied as a function of temperature in the liquid phase. Perpendicular diffusion coefficients calculated from ν3 agreed well with earlier reported results. The degenerate CH3 stretching vibration, ν4, was analyzed via fitting by a model incorporating two Lorentzian lineshapes. Values of the parallel diffusion constants, D∥, determined using only the narrower component were in excellent semi-quantitative agreement with those predicted by the free rotor model of molecular reorientation. Analysis of the room-temperatur Raman spectrum of ν5(E) yielded the same value of D∥ as that calculated from ν4. The room-temperature infrared spectral intensities of ν5 were fitted by a model with a narrow Lorentzian containing contributions from rotational and vibrational relaxation superposed on a second component introduced to account for the broad background absorption. D∥ determined from the IR bandwidth was in good agreement with values obtained from the Raman spectra of ν4 and ν5. These results demonstrate the utility of analyzing degenerate vibrational modes to determine the parallel diffusion coefficients in C3v molecules.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jrs.1250200510
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  • 10
    Electronic Resource
    Electronic Resource
    Raman and infrared study of reorientational dynamics in trifluorobenzene (1989)
    Chichester [u.a.] : Wiley-Blackwell
    Journal of Raman Spectroscopy 20 (1989), S. 27-30 
    Details
    ISSN: 0377-0486
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The Raman spectral bandwidths of two A1′ vibrations of 1,3,5-trifluorobenzene (TFB) were measured in the neat liquid as a function of temperature and in the solvents CH2Cl2 and CS2. The Raman and IR linewidths of two E′ modes were also measured in solution. Derived values of the two rotational diffusion constants, D⊥ and D∥, were compared with the predictions of several current theories. It was observed that the Hynes-Kapral-Weinberg (HKW) theory is superior to both the microviscosity-free rotor and Hu-Zwanzig ‘slip’ models of reorientational diffusion. Calculated values of D⊥ and D∥ for TFB in solution using the HKW model are in excellent agreement with the experimentally measured diffusion constants.
    Additional Material: 4 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jrs.1250200106
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