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  • 1
    Electronic Resource
    Electronic Resource
    Impaired insulin release in aging rats: Metabolic and ionic events (1993)
    Springer
    Cellular and molecular life sciences 49 (1993), S. 850-853 
    Details
    ISSN: 1420-9071
    Keywords: Aging ; glucose uptake ; calmodulin ; insulin release ; pancreatic islets
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We investigated the effect of aging on glucose uptake, glucose-induced O2 consumption, glucose-induced45Ca movements, and calmodulin content to elucidate age-related impairment of glucose-induced insulin release in pancreatic islets of Wistar rats. Intact pancreatic islets from old (24-month-old) rats showed impaired glucose-induced insulin release; glucose uptake and O2 consumption were lower in old than in young (2-month-old) or adult (12-month-old) rats. Moreover,45Ca uptake and calmodulin content were decreased in pancreatic islets from older rats, which explained the impairment in glucose-induced insulin release in aging. No major differences between the 3 age groups in glucose-induced45Ca efflux in pancreatic islets were observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01952596
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of a restricted diet on the in vitro glucose-induced insulin release of aging rats (1992)
    Springer
    Cellular and molecular life sciences 48 (1992), S. 996-998 
    Details
    ISSN: 1420-9071
    Keywords: Aging ; insulin release ; pancreatic islets ; dieting
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract To study the effect of a sudden loss of body weight on the β-cell function of aging rats, basal and glucose-induced insulin secretion was measured in pancreatic islets obtained from young (2-month-old), adult (12-month-old) and aging (24-month-old) rats, either fed ad libitum or fed a restricted diet (50% caloric restriction). Basal insulin secretion was similar in islets of young, adult and older rats. Glucose stimulated insulin release was significantly reduced in aging rats as compared to young animals. Animals fed a restricted diet showed a prolonged and higher secretory rate during first phase release when compared to animals fed ad libitum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01919151
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Total and individual determination of carbamate pesticides by use of an integrated flow-injection/HPLC system (1992)
    Springer
    Chromatographia 33 (1992), S. 449-453 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Flow injection analysis ; Combined flow injection/HPLC ; Carbamate pesticides
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary An integrated flow injection (FI)/HPLC system for the total and individual determination of carbamate pesticides (propoxur, carbofuran and carbaryl) is proposed. The determination is based on the alkaline hydrolysis of the analytes and subsequent coupling with diazotized sulphanilic acid to yield the monitored dyes with or without a prior separation step by HPLC in a C18 column. The calibration curves obtained are linear in the μg/ml range and r.s.d. values are between 0.5 and 3.7% in all instances. Injection of the sample into the FI manifold allows the total pesticide content in the sample to be screened. The manifold thus acts as a post-column reactor/detector of the chromatograph for samples with high overall carbamate content, which are also injected into the HPLC instrument. The performance was checked with contaminated water samples.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02262326
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Integrated FIA/HPLC method for preconcentration and determination of transition metal ions (1992)
    Springer
    Chromatographia 34 (1992), S. 445-449 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Flow injection analysis ; Combined methods ; Transition metal ions ; Aqueous samples
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary An automatic method based on the combination of a flow injection (FI) manifold with a liquid chromatograph has been developed for the enrichment and determination of transition metal ions in water samples. Alternatively, the FI configuration can be used as a screening system for the determination of the total concentration of heavy metals. Two-parameter expressions for calibration graphs involving preconcentration time and concentration of the analytes were established for both the FIA and the integrated FIA/HPLC methods. The preconcentration time depends on the concentration level of the analytes in the samples. The method is linear in the range 2–200 ng/ml, with r.s.d. values between 1.5 and 5.0. It has been applied to the determination of copper, lead, zinc, nickel, cobalt, cadmium and manganese in synthetic water samples.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02290233
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    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Aminopropyl-silica as an advantageous alternative to nonpolar sorbents for continuous cleanup/preconcentration of vitamin D3 metabolites (1998)
    Springer
    Chromatographia 47 (1998), S. 367-372 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Aminopropyl-silica sorbent ; Continuous cleanup/preconcentration ; Hydroxyvitamin D3 metabolites ; Flow injection analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A new procedure for continuous cleanup and concentration of hydroxyvitamin D3 metabolites prior to their separation by HPLC and UV-detection is reported. The process is based on the use of aminopropyl-silica as solid-phase sorbent as an alternative to the use of nonpolar sorbents. The improvement thus achieved has been tested by comparing the results with those obtained using octadecyl-C18 as non-polar sorbent. The comparison has been based on the calibration graphs (linear range, detection and quantitation limits), precision and multiple standard addition method.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02466466
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    Paper (German National Licenses)
    Fulltext
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