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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 271 (1981), S. 275-282 
    ISSN: 1432-069X
    Keywords: Percutaneous absorption ; Griseofulvin ; Proquazone ; Rat ; Human skin ; Percutane Absorption ; Griseofulvin ; Proquazon ; Ratte ; menschliche Haut
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Salben mit Griseofulvin respektive Proquazon wurden aus Monoglyceriden mittlerer Kettenlänge und einem aprotischen Lösungsmittel, Glycerinformal, hergestellt und auf dem Rücken von Gallefistelratten appliziert. Die percutan resorbierten Mengen sowie die Permeabilitätskonstanten sind für beide Wirkstoffe wesentlich höher nach Applikation der Salben als nach Applikation von einfachen Wirkstofflösungen ohne Monoglyceride. Die Verteilung der markierten Wirkstoffe in Rattenhaut wurde durch Mikroautoradiographie kontrolliert. Die Konzentrationen der Wirkstoffe in den einzelnen Schichten von menschlicher Haut sowie die mittleren Penetrationsraten wurden 16 h nach Applikation der Salben auf isolierte menschliche Haut bestimmt. Monoglyceride mittlerer Kettenlänge erhöhen die Permeabilität des Stratum corneum für gelöste Wirkstoffe wesentlich.
    Notes: Summary Ointments containing griseofulvin and proquazone, respectively, were made up of monoglycerides of medium chain length and an aprotic solvent, glycerinformal. The ointments were applied topically on the back of bile cannulated rats. The total amount absorbed percutaneously and the permeability constants of both drugs were considerably higher for the ointments than for simple solutions of the drugs without monoglycerides. Distribution of the labeled drugs in rat skin has been demonstrated by microautoradiography. Concentrations of the drugs in the different layers of human skin together with the medium flow rates have been determined 16h after administration of the ointments onto isolated human skin. Monoglycerides of medium chain length enhance significantly the permeability of the stratum corneum for solutes.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 282 (1990), S. 283-288 
    ISSN: 1432-069X
    Keywords: Elasticity ; Aging ; Suction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using a recently developed noninvasive, in vivo suction device for measuring skin elasticity, we evaluated age, sex, and regional differences in the viscoelastic properties of skin. A total of 33 volunteers participated in the study consisting of (a) 8 young females, (b) 9 old females, (c) 8 young males and (d) 8 old males. Measurements were performed on 11 anatomical regions; three different loads were applied: 100,200, and 500 mbar. The parameters used were: immediate distension (Ue); delayed distension (Uv); immediate retraction (Ur); and, final deformation (Uf). To compare between subjects and anatomical regions, relative parameters independent of skin thickness were calculated: Uv/Ue, the ratio between the viscoelastic properties of skin and immediate distension, and Ur/Uf, which measures the ability of the skin to regain its initial position after deformation. Generally, Uv/Ue increased while Ur/Uf decreased with aging. Responses were variable with respect to load applied. Variability within anatomical regions was also noted. However, differences between the sexes were not statistically significant for most regions. These findings are in congruence with earlier studies suggesting the differences are mainly attributable to alterations in the elastic fiber network. This procedure provides a simple, quantitative assessment of elastic properties of the skin. Its application may help in future investigations of other connective tissue disorders.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-069X
    Keywords: Percutaneous absorption ; Racial differences ; Blacks ; Caucasians ; Asians ; Benzoic acid ; Caffeine ; Acetylsalicylic acid ; Human skin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Individual differences exist between patients, and, for topical therapy, differences in skin due to race may be a consideration. Pharmacological response depends upon the percutaneous absorption and the inherent activity of the chemical once absorbed into the biological system. Our objective was to determine the in vivo percutaneous absorption of three test chemicals in human subjects with Asian (A), black (B) and Caucasian (C) ethnic skin. Following a 30 min topical application on the upper outer arm of 1 Μmol/cm2 14C-labeled chemical, percutaneous absorption was determined by both urinary excretion and the stripping technique. Amounts absorbed were: for benzoic acid 1.43 ± 0.27% (SD) (A), 1.07 ± 0.18% (B), 1.2 ± 0.19% (C); for caffeine 1.06 ± 0.17% (A), 1.01 ± 0.19% (B) and 0.96 ± 0.12% (C); for acetylsalicylic acid 1.8 ± 0.31% (A), 1.59 ± 0.31% (B) and 2.12 ± 0.36% (C). No statistical difference (P〉0.05) was found in percutaneous absorption of benzoic acid, caffeine or acetylsalicylic acid between Asian, black and Caucasian subjects.
    Type of Medium: Electronic Resource
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