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Red blood cell aging as a model to influence pharmacologically the red cell filterability (1981)

Grigoleit, H. -G. ; Leonhardt, H. ; Schröer, R. ; [et al.]

Springer

Research in experimental medicine 179 (1981), S. 249-254

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ISSN: 1433-8580

Keywords: Red cells ; Aging ; Red cell filterability ; Pharmacologic screening

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary A method to filter whole blood through 5-µm filters at a pressure of 20 cm column of water and the use of aging red cells as a reproducible procedure to generate rigidified cells is described. The system is sensitive enough to evaluate in pharmacologic screening possible influences of chemical agents on red cell deformability. Investigations with the methylxanthine derivates pentoxifylline and theophylline, the beta-blocker penbutolol and prednisolone, revealed that only the first compound has a dose-dependent effect on red cell deformability.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01851622

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