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  • 1
    Electronic Resource
    Electronic Resource
    Epstein-Barr virus-associated persistent polyclonal B-cell lymphocytosis with a distinct 69-base pair deletion in the LMP1 oncogene (1997)
    Springer
    Annals of hematology 74 (1997), S. 23-28 
    Details
    ISSN: 1432-0584
    Keywords: Key words Lymphocytosis ; Epstein-Barr virus ; LMP-1 ; LMP-2A ; Kindred
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Epstein-Barr virus (EBV) genomes have been detected in peripheral blood lymphocytes (PBL) of patients with persistent polyclonal B-cell lymphocytosis (PPBL). This is consistent with the hypothesis that latent EBV infection is involved in the pathogenesis of this disorder. Two EBV-encoded proteins expressed in viral latency are the latent membrane proteins 1 and 2A (LMP1 and LMP2A). We have studied the LMP1 oncogene and the LMP2A gene in a female patient with PPBL and her five siblings. A cell line derived from peripheral blood lymphocytes (PBL) of the patient was also analyzed. A distinct 69-base pair deletion was identified within the carboxy terminal NF-κB activation domain of the LMP1 oncogene in PBL of the patient and in the cell line, whereas none of the siblings harbored this deletion. The tyrosine-signaling motif and the HLA A2.1 epitope of the LMP2A gene were wild type in the patient and all siblings. The presence of a 69-base pair deletion variant of the LMP1 oncogene within the lymphocytes of a PPBL patient but absence of this deletion variant in the unaffected siblings suggests a direct implication of altered LMP1 oncoprotein-dependent function in the pathogenesis of PPBL.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050250
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  • 2
    Electronic Resource
    Electronic Resource
    Improvement of the empirical thermospheric model DTM: DTM94 – a comparative review of various temporal variations and prospects in space geodesy applications (1998)
    Springer
    Journal of geodesy 72 (1998), S. 161-178 
    Details
    ISSN: 1432-1394
    Keywords: Key words. Thermosphere models ; Non-gravitational forces ; Air drag ; Orbit determination ; Space geodesy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying
    Notes: Abstract. The Drag Temperature Model (1978) has been improved to respond better to the actual requirements of space geodesy, especially under extreme solar and geomagnetic conditions. Extended data and an improved algorithm have been considered, leading to valuable improvements. Temporal variations of temperature of the thermopause, total density and major chemical constituent density are reviewed and compared to the DTM94, DTM78 and MSIS86 models. A comparison with data is performed, giving the mean ratios between observed and model values with their root mean squares for different physical and geometric conditions. This comparison is made for the three models and includes data used in the modelling as well as external data. The limits of the thermosphere modelling are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001900050158
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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