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  • Airway  (1)
  • Bradykinin  (1)
  • Cat  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Lack of a role for bradykinin in allergen-induced airway microvascular leakage and bronchoconstriction in the guinea pig (1996)
    Springer
    Inflammation research 45 (1996), S. 123-126 
    Details
    ISSN: 1420-908X
    Keywords: Airway ; Allergen ; Bradykinin ; Bradykinin receptor ; HOE140
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have investigated the role of bradykinin in allergen-induced airway microvascular leakage and bronchoconstriction in sensitized guinea pigs. We used a selective bradykinin B2 receptor antagonist, HOE140, which has been shown to prevent the airway effects induced by bradykinin. Lung resistance (RL) was measured for 6 min after challenge with allergen. Extravasation of Evans blue dye into airway tissues was used as an index of the airway microvascular leakage. Aerosolized ovalbumin (5 mg/ml, 30 breaths) induced a significant increase in RL and leakage of dye in the trachea, main bronchi and intrapulmonary airways in the ovalbumin-sensitized guinea pigs. HOE140 given by inhalation (200 μM, 60 breaths) had no effect on the airway microvascular leakage and bronchoconstriction induced by the allergen. I.v. HOE140 (200 nmol/kg) did not significantly inhibit these airway responses. We conclude that bradykinin-mediated mechanism may not play a significant role in airway microvascular leakage or bronchoconstriction induced by allergen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02265164
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Morphological and physiological identification of neurons in the cat motor cortex which receive direct input from the somatic sensory cortex (1990)
    Springer
    Experimental brain research 80 (1990), S. 209-212 
    Details
    ISSN: 1432-1106
    Keywords: Pyramidal cells ; Nonpyramidal cells ; Cortico cortical fibers ; Sensory-motor ; Intracellular recording ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The population of neurons in the cat motor cortex which receives monosynaptic input from a specific functional region of the somatic sensory cortex was identified with the techniques of intracellular recording and staining with HRP. Both pyramidal and nonpyramidal cells located in the superficial layers of the pericruciate cortex responded to stimulation of the sensory cortex with short latency, excitatory postsynaptic potentials. More than half of the labeled cells were classified as pyramidal cells and the remainder as sparsely spinous or aspinous nonpyramidal cells. The characteristics of the EPSP's of the 2 groups of cells, ie. latency, time from beginning to peak and amplitude were found to vary only slightly. The results suggest that input from the sensory cortex impinges upon neurons which may in turn have an excitatory or inhibitory effect on corticofugal neurons in the motor cortex.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00228864
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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