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  • Airway hyperresponsiveness  (2)
  • B chain of oxidized insulin  (2)
  • Gastric mucosal aspartic proteinase  (2)
  • Inorganic Chemistry  (2)
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Material
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Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Proteolytic activity and cleavage specificity of cathepsin E at the physiological pH as examined towards the B chain of oxidized insulin
    Amsterdam : Elsevier
    FEBS Letters 292 (1991), S. 53-56 
    Details
    ISSN: 0014-5793
    Keywords: B chain of oxidized insulin ; Cathepsin E ; Cleavage specificity ; Gastric mucosal aspartic proteinase ; Proteolytic activity
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0014-5793(91)80832-N
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Proteolytic activity and cleavage specificity of cathepsin E at the physiological pH as examined towards the B chain of oxidized insulin
    Amsterdam : Elsevier
    FEBS Letters 292 (1991), S. 53-56 
    Details
    ISSN: 0014-5793
    Keywords: B chain of oxidized insulin ; Cathepsin E ; Cleavage specificity ; Gastric mucosal aspartic proteinase ; Nph ; PAGE ; Proteolytic activity ; SDS ; cya ; cysteic acid ; nitrophenylalanine ; polyacrylamide gel electrophoresis ; sodium dodecyl sulfate
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0014-5793(91)80832-N
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Airway epithelial cells modulate cholinergic neurotransmission in dog trachea (1994)
    Springer
    Lung 172 (1994), S. 241-249 
    Details
    ISSN: 1432-1750
    Keywords: Airway epithelial cell ; Airway hyperresponsiveness ; Vagus nerve ; Smooth muscle ; Neurotransmission
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We investigated the effects of epithelial cells on excitatory cholinergic neurotransmission in dog trachea, to shed more light on the role of airway epithelial cells in regulating airway responsiveness. Airway epithelial cells were prepared by an enzymatic dissociation of the tracheal mucosa using protease-free collagenase. Tracheal smooth muscle contractions evoked by electrical field stimulation (EFS) or acetylcholine (ACh) were measured before and after the application of epithelial cells. Isolated and dispersed epithelial cells (3 × 105 cells/ml) suppressed the amplitude of the twitch-like contractions evoked by EFS in the combined presence of guanethidine sulfate (10−6 m) and indomethacin (10−5 m). In contrast, epithelial cells did not affect the contraction evoked by exogenously applied ACh. Atropine (10−6 m) or tetrodotoxin (10−7 m) abolished the contraction evoked by electrical field stimulation. These findings indicate that airway epithelial cells inhibit the excitatory neurotransmission of the vagus nerve, presumably by suppressing the release of ACh. Airway epithelial cells may therefore play an important role in regulating the response of smooth muscle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00164441
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Ozone exposure suppresses epithelium-dependent relaxation in feline airway (1995)
    Springer
    Lung 173 (1995), S. 47-56 
    Details
    ISSN: 1432-1750
    Keywords: Airway hyperresponsiveness ; Ozone ; Airway epithelial cell ; Bronchiole ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We examined the effect of exposure to ozone on the epithelium-dependent relaxation (EpDR) of bronchioles evoked by electrical field stimulation (EFS) in a feline model with hyperresponsive airways induced by exposure to ozone. Airway responsiveness was assessed by measuring the increases in total pulmonary resistance (RL) produced by aerosolized acetylcholine (ACh) in vivo. Airway responsiveness was also measured in vitro in dissected bronchiolar ring preparations. Exposure to ozone (3 ppm, 2 h) significantly increased the airway responsiveness in vivo. The concentration of ACh required increasing R L to 200% of the baseline value, decreased from 1.97 mg/ml (GSEM 1.94) to 0.12 mg/ml (GSEM 1.77, p 〈 0.01) after exposure to ozone. EFS evoked atropine-, guanethidine-, and tetrodotoxin-resistant relaxations in the control bronchiolar rings precontracted by 5-hydroxytryptamine. Such relaxation was significantly suppressed by the mechanical denudation of epithelium, confirming that it was epithelium dependent. The amplitude of EpDR was significantly suppressed in the animals exposed to ozone. These results suggest that EpDR is present in cats, and that its inhibition may contribute to the development of airway hyperresponsiveness.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00167600
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Korrelation zwischen Mössbauer-Isomerieverschiebungen und ESCA-Bindungsenergien (1981)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 483 (1981), S. 75-85 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Correlation between Mössbauer Isomer Shifts and ESCA Binding EnergiesThe correlation between core-electron binding energies and Mössbauer isomer shifts is investigated and discussed for low-spin pentacyanoferrates(II), high-spin iron(III) compounds and high-spin iron(II) halides. The Fe2p3/2 binding energies of the investigated pentacyano ferrates(II) increase with decreasing isomer shifts as a consequence of the increasing π acid strengths of the sixth ligands. In contrast, the electron binding energies in high spin iron(III) compounds and iron(II) halides increase with increasing isomer shifts. This correlation is caused by the σ donor properties and the electronegativity of the ligands.
    Notes: Der Zusammenhang zwischen core-Elektronen-Bindungsenergien und Mössbauer-Isomerieverschiebungen wird für low-spin-Pentacyanoferrate(II), high-spin-Eisen(III)-Verbindungen und high-spin-Eisen(II)-halogenide untersucht und diskutiert. Die Fe2p3/2-Bindungsenergien der untersuchten Pentacyanoferrate(II) nehmen mit Kleiner werdenden Isomerieverschiebungen als Folge zunehmender π-Säurestärken der sechsten Liganden zu. Im Gegensatz dazu wachsen die Bindungsenergien der high-spin-Eisen(III)-Verbindungen und Eisen(II)-Halogenide mit zunehmender Isomerieverschiebung. Ursache sind die σ-Donoreigenschaften und die Elektronegativität der Liganden.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19814831210
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Mössbauer and X-ray photoelectron spectroscopic studies of prussian blue and its related compounds (1977)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 430 (1977), S. 241-249 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Mössbauer- und Röntgen-Photoelektronenspektroskopische Untersuchungen an Berlinerblau und verwandten VerbindungenDie 57Fe-Mössbauer-Spektren der drei isomorphen Verbindungen des Typs Fe4[MB(CN)6]3 · xH2O (MB = Fe, Ru bzw. Os) wurden im Temperaturbereich von -178 bis 25°C gemessen. Die Spektren der Ruthenium- und Osmium-Verbindungen sind sehr ähnlich dem des angereicherten 57Fe4[Fe(CN)6]3 · xH2O. Die Temperaturabhängigkeit der Isomerieverschiebung und der Quadrupolaufspaltung wird interpretiert als Ausdruck der Gitterdynamik. Die Röntgen-Photoelektronenspektren unterstützen die Schlußfolgerungen aus den Mössbauer-Untersuchungen.
    Notes: The 57Fe Mössbauer spectra of three isomorphous compounds of the type Fe4[MB(CN)6]3 · xH2O, where MB is Fe, Ru or Os, have been measured in the temperature range between -178 and 25°C. The spectral pattern of the ruthenium and osmium compounds is very similar to that of selectively enriched 57Fe4[Fe(CN)6]3 · xH2O. The temperature dependence of the isomer shift and quadrupole splitting is interpreted in terms of lattice dynamics. The X-ray photoelectron spectra also support the conclusions drawn from the Mössbauer study.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19774300123
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    Paper (German National Licenses)
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