ISSN:
1432-1106
Keywords:
Key words Parkinson’s Disease (PD)
;
Pedunculopontine nucleus (PPN)
;
Akinesia
;
Kainic acid (KA)
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The akinesia of Parkinsonism is relieved by pallidotomy and subthalamic nucleotomy, but not by thalamotomy. Therefore, this disabling symptom probably depends upon connections other than the pallidal-thalamocortical tracts, possibly efferents of the medial pallidum descending to the upper brainstem. We have previously demonstrated akinesia in the normal monkey following radiofrequency lesioning in the region of the pedunculopontine nucleus (PPN), one of the primary targets for descending pallidal outflow. Here, we confirm that selectively destroying neurones in the PPN area, whilst sparing fibres of passage, results in an akinetic state in normal macaques.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002210050921
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