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  • Systemic sclerosis  (3)
  • Akute Abdominalbeschwerden  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Anorectal function in systemic sclerosis (1997)
    Springer
    Diseases of the colon & rectum 40 (1997), S. 1328-1335 
    Details
    ISSN: 1530-0358
    Keywords: Systemic sclerosis ; Anorectal manometry ; Fecal incontinence ; Rectoanal inhibitory reflex ; Esophageal manometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract PURPOSE: This study was designed to compare esophageal and anorectal function parameters in patients with systemic sclerosis and to define the role of anorectal manometry in the diagnosis of gastrointestinal involvement of systemic sclerosis. PATIENTS AND METHODS: Twenty-six consecutive patients (22 females) with systemic sclerosis originally referred for assessment of esophageal function were evaluated by esophageal and anorectal manometry. Anorectal function parameters were compared between patients with normal and those with disturbed esophageal function. RESULTS: A total of 17 of 26 patients (65 percent) had severe esophageal dysfunction with aperistalsis of the lower two-thirds of the esophagus, whereas 9 patients (35 percent) had normal esophageal manometry. Only three patients (11.5 percent) suffered from occasional fecal incontinence. Anorectal function parameters (resting pressure, maximum squeeze pressure, perception threshold) were not significantly different between patients with normal and those with disturbed esophageal motility. Rectoanal inhibitory reflex was excitable in nearly 90 percent of patients. CONCLUSION: In an unselected group of patients with systemic sclerosis, fecal incontinence and abnormal anorectal function are rather rare findings. Anorectal manometry cannot differentiate between patients with and without gastrointestinal involvement of systemic sclerosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02050818
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Expression of RANTES in biopsies of skin and upper gastrointestinal tract from patients with systemic sclerosis (1999)
    Springer
    Rheumatology international 19 (1999), S. 39-46 
    Details
    ISSN: 1437-160X
    Keywords: Key words Chemokines ; Systemic sclerosis ; RANTES ; Keratinocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Inflammatory infiltrates and upregulated collagen production are hallmarks of systemic sclerosis (SSc). There are indications that chemokines are involved in accumulation of inflammatory and matrix-synthesizing cells in SSc skin lesions. Therefore, we searched for the expression and localization of the chemokine RANTES (“regulated upon activation and normal T cells expressed and secreted”) in skin and esophageal biopsies from patients with SSc. Using immunohistochemistry and in situ hybridization, skin biopsies derived from clinically involved and noninvolved skin of 18 patients with early and long-term SSc were examined for RANTES expression and compared with nondiseased skin sections of seven patients without SSc. In addition, esophageal snap biopsies were taken in a subgroup of six SSc patients. Strong expression of RANTES could be detected in the epidermis in keratinocytes of patients with short-term and long-term disease, both on the mRNA and protein level. The percentage of RANTES-expressing cells were significantly higher in clinically noninvolved skin sections than in involved skin areas. In contrast, no RANTES expression was found in esophageal biopsies or in the control group. The results indicate that RANTES is present in human sclerodermatous skin. RANTES may be involved in early pathogenesis of SSc as well as in fibrosis pathways, either by chemoattraction of immunocompetent cells and/or by modulation of collagen production.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002960050098
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Gallbladder motility in systemic sclerosis (1996)
    Springer
    Rheumatology international 16 (1996), S. 61-65 
    Details
    ISSN: 1437-160X
    Keywords: Gallbladder motility ; Systemic sclerosis ; Ultrasonography ; Oesophageal manometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In 20 patients with systemic sclerosis (SSc) and 24 healthy controls, gallbladder motility was evaluated by abdominal ultrasonography after stimulation by a standard liquid meal. Results from patients with normal and dis turbed oesophageal function were analysed separately in order to investigate the significance of gallbladder motility as a parameter for gastrointestinal involvement in SSc. All patients showed a marked decrease in gallbladder size after stimulation (patients 61 ±13%; controls 48 ±12%). Patients with oesophageal dysfunction (n=12) had a slightly lower gallbladder contraction (maximal decrease =58±13%) when compared to patients with normal oesophageal function (n=8; 66± 13%); however, this difference was not statistically significant. Gallbladder motility in patients with SSc was not reduced when compared with healthy controls. SSc-induced oesophageal dysfunction was not associated with impaired gallbladder motility. Thus, measurement of gallbladder emptying is not a helpful tool when looking for gastrointestinal involvement in SSc.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01816437
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Präklinische Notfallmedizin Akutes Abdomen (1998)
    Springer
    Der Internist 39 (1998), S. 161-170 
    Details
    ISSN: 1432-1289
    Keywords: Schlüsselwörter Akutes Abdomen ; Akute Abdominalbeschwerden ; Präklinische Versorgung ; Notfallmedizin ; Notfall ; Abdomen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zum Thema Auch in der heutigen Diagnostik, die so häufig durch technisch gestützte Untersuchungen beherrscht wird, nimmt das akute Abdomen mit seiner besonderen Anforderung an klinisch-ärztliche Qualitäten eine Sonderstellung ein. Diagnostik und Befunderhebung stehen dabei ganz im Vordergrund. Sehr bemerkenswert ist, daß bei Patienten unter 50 Jahren in fast 40% keine eindeutige Diagnose gestellt werden kann, bei Patienten über 50 Jahren nur in ca. 15%. Unter den Diagnosen ist die akute Appendizitis bei den unter 50-Jährigen ca. doppelt so häufig wie bei den über 50-Jährigen, bei denen mit ca. 20% die Cholezystitis die häufigste Ursache ist. Die Mortalität steigt mit dem Lebensalter langsam an, erreicht um das 50. Lebensjahr ca. 1% und um das 80. Lebensjahr ca. 7%. Die vorliegende Arbeit gibt einen Überblick sowohl über die abdominellen als auch nicht abdominellen Ursachen des akuten Abdomens. Diagramme zur Ursache, Anamnese, klinischen Diagnostik und zu Befunden ergänzen den Textteil.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001080050154
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    Paper (German National Licenses)
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