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  • Akute gastroduodenale Läsionen  (1)
  • Beinschwäche-Syndrom  (1)
  • Bone  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Einflüsse verschiedener Vitamin-D-Metaboliten auf das Beinschwäche-Syndrom bei Mastputen (1990)
    Springer
    European journal of nutrition 29 (1990), S. 178-183 
    Details
    ISSN: 1436-6215
    Keywords: Vitamin-D-Metaboliten ; Beinschwäche-Syndrom ; Truthühner ; Vitamin-D-Hypervitaminose ; vitamin D-metabolites ; leg weakness ; turkeys ; vitamin D hypervitaminosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Description / Table of Contents: Summary In two experiments the influence of vitamin D metabolites on leg weakness in turkeys belonging to the Big 6 line was studied. The metabolites were given orally or intravenously in different dosages. There are no differences in vitamin-D-dependent parameters between healthy turkeys and turkeys with leg weakness. Additional oral application of 1,25 (OH)2D3 in dosages of 2, 5 or 10 μg per animal day and of 400 μg 25 (OH)D3 per animal day had no influence on leg weakness. Even after intravenous application of 2 or 5 μg 1,25(OH)2D3 per animal day there were no changes concerning the degree of leg weakness nor were any signs of hypervitaminosis D observed (increase of serum calcium level or increase of the activity of duodenal calcium binding protein). Our results indicate that this form of leg weakness in turkeys is not connected to a disturbance of vitamin D metabolism.
    Notes: Zusammenfassung In zwei Versuchen mit beinschwachen Truthähnen der Mastlinie „BIG 6“ wurde der Einfluß verschiedener Vitamin-D-Metaboliten nach oraler bzw. intravenöser Verabreichung untersucht. Zwischen kranken und gesunden Tieren wurden bei den Vitamin-D-abhängigen Parametern keine Unterschiede festgestellt. Zusätzliche orale Gaben mittels Schlundsonde von 1,25(OH)2D3 in einer Dosierung von 2, 5 bzw. 10 μg pro Tier und Tag sowie von 400 μg 25(OH)D3 pro Tier und Tag hatten keinen Einfluß auf die Erkrankung. Bei i.v. Applikation von 2 bzw. 5 μg 1,25(OH)2D3 pro Tier und Tag traten keinerlei Anzeichen einer Besserung des Gesundheitszustandes, aber auch keine Hinweise auf eine Hypervitaminose (Erhöhung des Serumcalciumspiegels bzw. Anstieg der Aktivität des Calcium bindenden Proteins) auf. Die untersuchte Form der Beinschwächeerkrankung bei Mastputen ist offensichtlich nicht mit einer Störung des Vitamin-D-Stoffwechsels verbunden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02021556
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Characterization of glycoconjugate expression during development of Meckel's cartilage in the rat (1995)
    Springer
    Anatomy and embryology 191 (1995), S. 47-59 
    Details
    ISSN: 1432-0568
    Keywords: Bone ; Lectins ; Mandible ; Meckel's cartilage ; Rat embryo
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The staining patterns of 24 biotinylated lectins were analyzed in serial sections of the mandible of 13- to 21-day-old rat embryos by means of the avidinbiotin-peroxidase method. A ubiquitous distribution of binding sites was demonstrated after incubation with Con A (Canavalia ensiformis), DSL (Datura stramonium; except bone matrix), and WGA (Triticum vulgare). ECL (Erythrina cristagalli), GSL I (Griffonia simplicifolia), SJA (Saphora japonica), VVL (Vicia villosa), DBA (Dolichus biflorus), UEA I (Ulex europeus), and LTA (Lotus tetragonobolus) were constantly negative. In early stages of development, GSL II (Griffonia simplicifolia II) was a selective marker of prechondral blastema. In contrast, PNA (Arachis hypogaea) did not stain condensing mesenchyme. During chondrogenesis of Meckels's cartilage a general decrease of lectin binding was observed. Mature cartilage matrix was constantly negative. Chondrocytes were marked by the lectins PSA (Pisum sativum), WGA, PHA-E, and PHA-L (Phaseolus vulgaris E and L). A strong GSL II binding was restricted to the mesial-superior region of the perichondrium. In later stages, several lectins revealed significant differences between preskeletal (“central”) areas and the remaining (“peripheral”) mesenchyme. A clear binding reaction was noted in central regions by applying LEA (Lycopersicon esculentum) and STL (Solanum tuberosum), while the peripheral tissue was only faintly stained. Developing bone was specifically marked by succinylated WGA (sWGA). The lectins LCA (Lens culinarus) and RCA (Ricinus communis) bound to fibers and extracellular matrix of the connective tissue. Jacalin (Artocarpus integrifolia) and SBA (Glycine max) binding sites were found in macrophages. Affinity of VAA (Viscum album) increased parallel with maturation of endothelial cells. Specific lectin-binding patterns revealed no correlation with the distribution of glycosaminoglycans. The results demonstrate a general reduction of oligosaccharide structures during development of Meckel's cartilage. From our observations we conclude that intralaminar glucose and/or mannose sequences as well as terminal sialic acid molecules are ubiquitously distributed, while terminal α-fucose was constantly negative. Lectin-binding patterns of macrophages may reflect the presence of specifically linked terminal galactose. Our findings indicate that oligosaccharides terminating in N-acetylglucosamine are bone-specific. The significance of the restricted staining of the perichondrium by GSL II remains to be elucidated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00215297
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    217. Ranitidin versus Cimetidin in der Kontrolle des intragastralen pH-Wertes bei chirurgischen Intensivpflegepatienten mit Peritonitis und Sepsis — Eine Doppelblindstudie (1984)
    Springer
    Langenbeck's archives of surgery 364 (1984), S. 538-539 
    Details
    ISSN: 1435-2451
    Keywords: Acute gastroduodenal lesions ; Intragastric pH ; Cimetidine ; Ranitidine ; Akute gastroduodenale Läsionen ; Intragastraler pH ; Cimetidin ; Ranitidin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 12 beatmete Intensivpatienten mit Peritonitis bzw. Sepsis wurden in einer prospektiv randomisierten Doppelblindstudie mit 300 mg Ranitidin/d bzw. 2 g Cimetidin/d jeweils über Dauerinfusion behandelt. Beide Untersuchungsgruppen waren hinsichtlich Alter, Geschlecht und Gefährdungsgrad streßinduzierter Blutungen vergleichbar. Durch Ranitidin gelang eine zur Blutungsprophylaxe ausreichende, wenn auch nicht vollständige Kontrolle des intragastralen pH-Wertes. Mit Cimetidin als Monotherapie konnten wir dagegen selbst in einer hohen Dosierung (2 g/d) bei unserem Patientengut keine ausreichende Kontrolle des Magen-pH-Wertes erzielen. Für 3 Patienten erwies sich sogar die Kombination von Cimetidin mit 2 × 10 mg Pirenzepin/d als nicht ausreichend.
    Notes: Summary Twelve patients in an intensive care unit on a respirator who had peritonitis or sepsis were treated with 300 mg/day of ranitidine or 2 g cimetidine/day, which was administered via perfusor infusion under the conditions of a random double-blind study. Both groups under study were comparable with respect to age, sex, and grade risk of stress-induced bleeding. With ranitidine, we were able to control bleeding sufficiently, but not completely control intragastric pH values. With cimetidine as monotherapy, however, even under the high dosage of 2 g/day, we were not successful in controlling intragastric pH. With three patients even the combination of ranitidine and 2 × 10 mg pirenzepine/day did not prove sufficient.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01823391
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    Paper (German National Licenses)
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