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  • 1
    Electronic Resource
    Electronic Resource
    The effects of recombinant insulin-like growth factor I administration on growth hormone levels and insulin requirements in adolescents with Type 1 (insulin-dependent) diabetes mellitus (1993)
    Springer
    Diabetologia 36 (1993), S. 678-681 
    Details
    ISSN: 1432-0428
    Keywords: Type 1 (insulin-dependent) diabetes mellitus ; insulin requirements ; insulin-like growth factor I ; growth hormone ; adolescence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Type 1 (insulin-dependent) diabetes mellitus in adolescence is associated with reduced levels of insulin-like growth factor I, elevated growth hormone concentrations and insulin resistance. In order to determine whether restoring insulin-like growth factor I levels to normal might lead to a reduction in growth hormone levels and insulin requirements, we undertook a double-blind placebo controlled study of a single s. c. dose of recombinant insulin-like growth factor I (40 μg/kg body weight) in nine late pubertal subjects with Type 1 diabetes. After administration of placebo or insulin-like growth factor I at 18.00 hours, a variable rate insulin infusion was used to maintain euglycaemia overnight. Plasma insulin-like growth factor I, growth hormone, free insulin, and intermediate metabolite concentrations were monitored throughout the study. Recombinant insulin-like growth factor I led to a rise in plasma concentrations which reached a peak at 5.5 h (413.1±28.2 ng/ml, mean±SEM). Mean growth hormone levels between 20.00 and 08.00 hours were significantly reduced after recombinant insulin-like growth factor I (19.4±4.0 compared with 33.6±5.8 mU/l; p=0.01), as were the insulin requirements for euglycaemia (0.25±0.02 compared with 0.31±0.04 mU · kg−1 · min−1; p=0.03). Plasma free insulin levels were lower after recombinant insulin-like growth factor I administration (31.9±2.7 compared with 67.9±16.0 mU/l; p=0.001) but no significant differences in ketone or lactate levels were detected. Recombinant insulin-like growth factor I in a s. c. dose of 40 μg/kg body weight leads to a significant reduction in overnight growth hormone levels and insulin requirements in adolescents with Type 1 diabetes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00404081
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Subcortical afferent and efferent connections of the superior colliculus in the rat and comparisons between albino and pigmented strains (1986)
    Springer
    Experimental brain research 62 (1986), S. 131-142 
    Details
    ISSN: 1432-1106
    Keywords: Superior colliculus ; Horseradish peroxidase ; Connections ; Albinism ; Thalamus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Subcortical connections of the superior colliculus were investigated in albino and pigmented rats using retrograde and anterograde tracing with horseradish peroxidase (HRP), following unilateral injection of HRP into the superior colliculus. Afferents project bilaterally from the parabigeminal nuclei, the nucleus of the optic tract, the posterior pretectal region, the dorsal part of the lateral posterior-pulvinar complex and the ventral nucleus of the lateral lemniscus; and ipsilaterally from the substantia nigra pars reticulata, the pars lateralis of the ventral lateral geniculate nucleus, the intergeniculate leaflet, the zona incerta, the olivary pretectal nucleus, the nucleus of the posterior commissure, the lateral thalamus, Forel's field H2, and the ventromedial hypothalamus. Collicular efferents terminate ipsilaterally in the anterior, posterior and olivary pretectal nuclei, the nuclei of the optic tract and posterior commissure, the ventrolateral part of the dorsal lateral geniculate nucleus, the pars lateralis of the ventral lateral geniculate nucleus, the intergeniculate leaflet, and the zona incerta; and bilaterally in the parabigeminal nuclei and lateral posterior-pulvinar complex (chiefly its dorsal part). The general topographical patterns of some of the afferent and efferent projections were also determined: the caudal and rostral parts of the parabigeminal nucleus project to the caudal and rostral regions, respectively, of the superior colliculus; caudal superior colliculus projects to the most lateral, and lateral superior colliculus to the most caudal part of the terminal field in the dorsal lateral geniculate nucleus; caudolateral superior colliculus projects to the caudal ventrolateral part of the ventral lateral geniculate nucleus, while rostromedial parts of the colliculus project more rostrally and dorsomedially. Following comparable injections in pigmented and albino animals, fewer retrogradely labelled cells were found in subcortical structures in the albino than in the pigmented rats. The difference was most marked in nuclei contralateral to the injected colliculus. Thus, the effects of albinism on the nervous system may be more widespread than previously thought.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00237409
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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