ISSN:
1432-1041
Keywords:
Albumin
;
protein binding
;
inhibition by palmitate
;
multiligand analysis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary Palmitic acid a common contaminant of albumin preparations, competitively inhibits the binding of sulphamidochlorobenzoicacid (SCBA) to human albumin thus decreasing its observed affinity. The effect of palmitic acid depends on its concentration, i.e. the purity and concentration of the albumin preparation used. The correct value for SCBA affinity was obtained by correcting the experimental data according to the palmitic acid concentration by use of a multiligand analysis method.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00562457
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