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  • Aldosterone  (3)
  • Arginine-vasotocin  (1)
  • Diabetic embryopathy  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Myo-inositol and prostaglandins reverse the glucose inhibition of neural tube fusion in cultured mouse embryos (1990)
    Springer
    Diabetologia 33 (1990), S. 593-596 
    Details
    ISSN: 1432-0428
    Keywords: Diabetic embryopathy ; myo-inositol ; prostaglandins ; neural tube ; mouse embryos
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Neural tube defects in infants of diabetic mothers constitute an important and frequent cause of neonatal mortality/morbidity and long-term chronic handicaps. The mechanism by which normal neural tube fusion occurs is not known. The failure of rostral neural tube fusion seen in mouse embryos incubated in the presence of excess-D-glucose can be significantly prevented by the supplementation of myo-inositol to the culture medium. This protective effect of myo-inositol is reversed by indomethacin, an inhibitor of arachidonic acid metabolism leading to prostaglandin synthesis. Prostaglandin E2 added to the culture medium completely protects against the glucose-induced neural tube defect. These data suggest that the failure of neural tube fusion seen in diabetic embryopathy is mediated through a mechanism involving abnormalities in both the myo-inositol and arachidonic acid pathways, resulting in a functional deficiency of prostaglandins at a critical time of neural tube fusion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400202
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Radioimmunoassay for arginine-vasotocin (AVT) in serum of Pekin ducks: AVT concentrations after adaptation to fresh water and salt water (1980)
    Springer
    Pflügers Archiv 387 (1980), S. 91-97 
    Details
    ISSN: 1432-2013
    Keywords: Arginine-vasotocin ; Radioimmunoassay ; Avian osmoregulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A radioimmunoassay for arginine-vasotocin (AVT), the antidiuretic principle in birds, was developed using the high cross-reactivity of AVT with an AVP antiserum raised in rabbits. This assay is specific for the measurement of AVT in serum of birds. The sensitivity and precision is such that serum AVT concentrations above 0.5 fmol/ml can be measured quantitatively. A serum AVT concentration of 5.1±1.4 fmol/ml was found in normally hydrated, fresh water adapted ducks with a serum osmolality of 293.7±2.2 mosmol/kg. When the same animals were acutely hydrated, no or〈0.5 fmol/ml AVT was present at an osmolality of 289.9±2.4 mosmol/kg. In salt water adapted ducks with a serum osmolality of 333.0±7.6 mosmol/kg, a serum AVT of 22.7±3.0 fmol/ml was found. When fresh water adapted ducks were hydrated and infused with different doses of AVT, a linear relationship between serum AVT and the amount infused was obtained. During AVT infusions, serum osmolality and urine flow rate were negatively correlated and urine osmolality was positively correlated with serum AVT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00584258
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Zum extrahepatischen Stoffwechsel von Aldosteron (1968)
    Springer
    Clinical and experimental medicine 145 (1968), S. 270-277 
    Details
    ISSN: 1591-9528
    Keywords: Aldosterone ; Kidney ; Stop flow dog ; Aldosteron ; Niere ; Stop flow-Hund
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Mit Stop flow-Versuchen an Hunden konnten wir nach Infusion von 1,2-3H-18-Aldosteronglucuronid im Gegensatz zur Infusion von freiem 1,2-3H-Aldosteron keine proximale Sekretion von 1,2-3H-18-Aldosteronglucuronid nachweisen. Daraus kann geschlossen werden, daß in Hundenieren die proximalen Tubuluszellen wohl 18-Aldosteronglucuronid aus Aldosteron bilden und an das Tubuluslumen abgeben, während im Nierenarterienblut vorhandenes 18-Aldosteronglucuronid nur glomerulär filtriert und ausgeschieden wird.
    Notes: Summary In stop flow experiments during infusion of 1,2-3H-18-aldosterone glucuronide there was no proximal tubular secretion of this metabolite in contrary to experiments during infusion of 1,2-3H-aldosterone. The discrepancy must be explained by formation of 1,2-3H-aldosterone glucuronide out of3H-aldosterone in proximal tubular cells, while the 1,2-3H-18-aldosterone glucuronide in the plasma of the renal artery blood is only filtered in the glomerulum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02044618
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  • 4
    Electronic Resource
    Electronic Resource
    Zum extrahepatischen Stoffwechsel von Aldosteron (1968)
    Springer
    Clinical and experimental medicine 146 (1968), S. 336-345 
    Details
    ISSN: 1591-9528
    Keywords: Aldosterone ; Kidney ; Man ; Aldosteron ; Niere ; Mensch
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Auf Grund eines Vergleiches der Verhältnisse von 1,2-3HTetrahydroaldosteronglucuronid zu 1,2-3H-18-Aldosteronglucuronid im Plasma von drei Normalpersonen und zwei nephrektomierten Patienten nach einer Injektion von 1,2-3H-Aldosteron haben wir folgende Schlüsse in Betracht gezogen: 1. Das im Blutplasma vorhandene 1,2-3H-18-Aldosteronglucuronid wird nur glomerular filtriert. 2. Die renale Clearance von 18-Aldosteronglucuronid, die etwa das Fünffache der Inulinclearance beträgt [13, 15], mu\ zu vier Fünfteln auf Bildung von 18-Aldosteronglucuronid durch die proximalen [15] Tubuluszellen zurückgeführt werden. 3. Das Ausma\ der renalen Bildung von 18-Aldosteronglucuronid liegt in einer Grö\enordnung von 80% der Gesamtmenge 18-Aldosteronglucuronid im 24 StdUrin.
    Notes: Summary After an intravenous injection of 1,2-3H-aldosterone the ratios of 1,23H-tetrahydroaldosterone glucuronide to 1,2-3H-aldosterone glucuronide in the blood plasma of three normal and two nephrectomized persons were compared. In the three normal persons the ratios were of the same magnitude as in the two nephrectomized persons. On the basis of glomerular filtration of tetrahydroaldosterone glucuronide, as previously demonstrated by renal clearance studies in man [13, 15] and stop flow experiments in dogs [6], we made the following deductions: 1. 18aldosterone glucuronide in blood plasma is only filtered in the glomerulum. 2. The renal clearance of 18-aldosterone glucuronide, as investigated during aldosterone infusion in man [13, 15], therefore must be explained by glomerular filtration of only one fifth and by formation of four fifth of 18-aldosterone glucuronide by proximal [15] tubular cells. 3. This means that about 80% of 18-aldosterone glucuronide excreted in urine is formed by the kidneys.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02045932
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  • 5
    Electronic Resource
    Electronic Resource
    Zum extrahepatischen Stoffwechsel von Aldosteron (1968)
    Springer
    Clinical and experimental medicine 146 (1968), S. 329-335 
    Details
    ISSN: 1591-9528
    Keywords: Aldosterone ; Metabolism ; Protein-binding ; Renal clearance ; Aldosteron ; Stoffwechsel ; Eiwei\bindung ; Nierenclearance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Im menschlichen Blutplasma wurde vermittels äquilibriumDialyse die Eiwei\bindung für Tetrahydroaldosteronglucuronid mit 35–39% und diejenige für 18-Aldosteronglucuronid mit 54–57% bestimmt. Auf Grund dieser Werte und der früher mitgeteilten renalen Clearance dieser beiden Aldosteronmetaboliten, welche die Eiwei\bindung nicht berücksichtigte [13], ergibt sich für das Tetrahydroaldosteronglucuronid eine renale Clearance im Bereich derjenigen des Inulins und für das 18-Aldosteronglucuronid eine solche im Bereich der PAHClearance.
    Notes: Summary In equilibrium dialysis with human blood plasma and human albumin the protein binding of tetrahydroaldosterone glucuronide was 35 to 39% and the protein binding of 18-aldosterone glucuronide was 54 to 57%. The “uncorrected” renal clearance values of these two aldosterone metabolites, as published bySiegenthaler et al. [13], were “corrected” for protein binding. So the renal clearance of tetrahydroaldosterone glucuronide is similar to the renal clearance of inulin, whereas the renal clearance of 18-aldosterone glucuronide lies in the range of the PAH clearance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02045931
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