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Inching toward reality: An improved likelihood model of sequence evolution (1992)

Thorne, Jeffrey L. ; Kishino, Hirohisa ; Felsenstein, Joseph

Springer

Journal of molecular evolution 34 (1992), S. 3-16

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ISSN: 1432-1432

Keywords: Alignment ; Maximum likelihood procedure ; Dynamic programming ; Evolutionary model ; Insertion-deletion model

Source: Springer Online Journal Archives 1860-2000

Topics: Biology

Notes: Summary Our previous evolutionary model is generalized to permit approximate treatment of multiple-base insertions and deletions as well as regional heterogeneity of substitution rates. Parameter estimation and alignment procedures that incorporate these generalizations are developed. Simulations are used to assess the accuracy of the parameter estimation procedure and an example of an inferred alignment is included.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00163848

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