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  • 1
    Electronic Resource
    Electronic Resource
    Immunohistochemical study ofneu protein overexpression in clinging in situ duct carcinoma of the breast (1993)
    Springer
    Virchows Archiv 422 (1993), S. 375-380 
    Details
    ISSN: 1432-2307
    Keywords: Neu protein ; Breast cancer ; Oncogene ; In-situ duct carcinoma ; Clinging carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The expression ofneu protein in 26 cases of clinging carcinoma (CC) of the breast was investigated. A distinction is made between two types of CC: one with pleomorphic nuclei (PN) and the other with monomorphic nuclei (MN). The PN type of CC overexpresses theneu protein in almost all cases (85.7%), its cells generally exhibit abundant cytoplasm and intraluminal necrosis is frequently observed. The MN type of CC does not overexpress theneu protein, exhibits bland cytological features and shows no necrosis. It is suggested that CC with PN is related to comedo-type carcinoma, while CC with MN is the forerunner of cribriform carcinoma in situ.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01605456
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The neu-protein and breast cancer (1995)
    Springer
    Virchows Archiv 426 (1995), S. 107-115 
    Details
    ISSN: 1432-2307
    Keywords: neu ; c-erbB2 ; Oncogene ; Breast cancer ; Paget's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The neu-protein is overexpressed in about 20% of invasive duct cell carcinomas of the breast. The only reliable sign for neu-overexpression by immunohistochemistry is membrane staining. Its overexpression is correlated with decreased overall survival and disease free survival due to increased metastatic activity of neu-overexpressing tumour cells. This increased metastatic potential is a consequence of the motility enhancing activity of the neu-protein, which is exclusively expressed on pseudopodia, and to a lesser extent of its growth stimulating effect. From a clinical point of view, the assessment of neu-overexpression in breast cancer might become a useful tool in the future treatment of patients by chemotherapy, since patients whose tumour shows neu-overexpression benefit from higher doses of chemotherapy. The molecule plays a key role in the pathogenesis of Paget's disease of the breast. A chemotactic factor which is secreted by epidermal keratinocytes attracts the Paget cells to spread into the epidermis and acts via the neu-protein. In ductal carcinoma in situ, the combination of neu-overexpression and large cell type is highly correlated with extent of disease and therefore neu-overexpression might be a predictive marker for recurrence of disease after tumour resection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00192631
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Chirale Lactole, XI. Eine Methode zur Bestimmung der Absolutkonfiguration chiraler Alkanole (1994)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 127 (1994), S. 887-892 
    Details
    ISSN: 0009-2940
    Keywords: Configuration, absolute ; Alkanols, chiral ; Acetals ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Chiral Lactols, XI. - A Method for the Determination of the Absolute Configuration of Chiral AlkanolsChiral secondary alcohols which are protected with the enantiomerically pure lactol 1 or 2 show significant differences in 13C-chemical shifts around the glycosidic linkage. An easy method for determination of the absolute configuration of secondary alcohols based on this fact is described.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19941270516
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    Paper (German National Licenses)
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