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  • 1
    Electronic Resource
    Electronic Resource
    Morphological study in the early stages of complement C5a fragment-induced experimental meningitis: activation of macrophages and astrocytes (1995)
    Springer
    Acta neuropathologica 89 (1995), S. 239-247 
    Details
    ISSN: 1432-0533
    Keywords: Key words Meningitis ; C5a complement ; Macrophage ; Astrocyte
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Subarachnoidal application of the complement C5a fragment was used to induce acute experimental meningitis in rabbits and rats within 30–60 min. The early stages of the cellular inflammatory response were studied by means of flow cytometry, transmission electron microscopy and immunofluorescence microscopy. Infiltration of polymorphonuclear leukocytes (PMN) into the subarachnoidal space was the earliest event of the inflammatory reaction. By morphological criteria we found that PMN interacted with cells of the mononuclear-macrophage lineage (MML) and the marginal astrocytes via pseudopodia, whereas the pial cells were not involved in early stages of the inflammatory response. The number of invaded MML that were positive with the ED2 marker increased, indicating the hematogenous origin of the immigrating cell population. PMN were found to infiltrate the perivascular space of the marginal arterial vessel segments. This perivascular infiltration was assumed to be the first manifestation of cerebral vasculitis. The intimate association of resident cerebral cells (astrocytes) with invading PMN and MML is suggestive of a transient interaction of these cell types.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00309339
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Morphological study in the early stages of complement C5a fragment-induced experimental meningitis: activation of macrophages and astrocytes (1995)
    Springer
    Acta neuropathologica 89 (1995), S. 239-247 
    Details
    ISSN: 1432-0533
    Keywords: Meningitis ; C5a complement ; Macrophage ; Astrocyte
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Subarachnoidal application of the complement C5a fragment was used to induce acute experimental meningitis in rabbits and rats within 30–60 min. The early stages of the cellular inflammatory response were studied by means of flow cytometry, transmission electron microscopy and immunofluorescence microscopy. Infiltration of polymorphonuclear leukocytes (PMN) into the subarachnoidal space was the earliest event of the inflammatory reaction. By morphological criteria we found that PMN interacted with cells of the mononuclear-macrophage lineage (MML) and the marginal astrocytes via pseudopodia, whereas the pial cells were not involved in early stages of the inflammatory response. The number of invaded MML that were positive with the ED2 marker increased, indicating the hematogenous origin of the immigrating cell population. PMN were found to infiltrate the perivascular space of the marginal arterial vessel segments. This perivascular infiltration was assumed to be the first manifestation of cerebral vasculitis. The intimate association of resident cerebral cells (astrocytes) with invading PMN and MML is suggestive of a transient interaction of these cell types.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00309339
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Gemeinsames Auftreten von Ochronose und chronischer Polyarthritis bei einer Patientin (1998)
    Springer
    Zeitschrift für Rheumatologie 57 (1998), S. 50-52 
    Details
    ISSN: 0340-1855
    Keywords: Schlüsselwörter Ochronose ; Alkaptonurie ; Chronische Polyarthritis ; Key words Ochronosis ; alkaptonuria ; rheumatoid arthritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Ochronosis is a rare disorder of tyrosin catabolism with an autosomal, recessive trait. Clinical signs predominantly affect the locomotor system. Inflammatory episodes in large joints can mimick Rheumatoid Arthritis (RA). Brownish discoloration of sclerae and cartilage is characteristic, diagnosis is confirmed by typical changes of spinal X-rays and the finding of homogentisic acid in urine samples. We describe a case of a 53 year old female patient with ochronosis and a second diagnosis of RA.
    Notes: Zusammenfassung Die Ochronose ist eine seltene, autosomal rezessiv vererbte Störung des Tyrosinabbaus. Ihre Symptome manifestieren sich überwiegend am Bewegungsapparat. Entzündungsschübe insbesondere an den großen Gelenken können eine Chronische Polyarthritis (CP) vortäuschen. Charakteristisch sind bräunliche Verfärbungen der Skleren und Knorpel, die Diagnose kann dann durch typische Röntgenveränderungen der Wirbelsäule und den Nachweis von Homogentisinsäure im Urin gesichert werden. Wir beschreiben den Fall einer 53-jährigen Patientin mit Ochronose und einer zusätzlichen CP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003930050060
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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