ISSN:
1432-1106
Keywords:
Tremorogenic agents
;
Oxotremorine
;
Renshaw cells
;
Alpha motoneurons
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary In intercollicular decerebrate cats, some of which were made spinal in addition, the effect of oxotremorine (intravenous injection, 10–30 μg/kg) was tested on antidromically activated Renshaw cells. Methylatropine premedication prevented the otherwise often fatal drop in blood pressure; ipsilateral dorsal roots L6-S1 and contralateral hindlimb nerves were cut to exclude segmental receptor interference. During supramaximal stimulation of ventral root L7 or the gastrocnemius nerves, an increase of activity ranging from 10–110% was observed. The drug occasionally evoked spontaneous discharges in Renshaw cells, or enhanced activity already present. Alpha motoneuron activity decreased in most cases. The interaction of oxotremorine with atropine and eserine was also investigated on Renshaw cells. Our results suggest that one of the effects of oxotremorine may be a disbalance between motor output and recurrent inhibition.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00237324
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