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  • 1
    Digitale Medien
    Digitale Medien
    The efficacy of ginseng. A systematic review of randomised clinical trials (1999)
    Springer
    European journal of clinical pharmacology 55 (1999), S. 567-575 
    Details
    ISSN: 1432-1041
    Schlagwort(e): Key words Ginseng ; Herbal medicine ; Alternative medicine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Abstract Objective: Ginseng is one of the most popular herbal remedies, and a number of health claims are made for it. This systematic review provides an evaluation of the current evidence for or against the efficacy of ginseng root extract. Methods: Searches of the computerised literature databases Medline, Embase, Biosis, CISCOM and the Cochrane Library were performed to retrieve double-blind, randomised, placebo-controlled trials of ginseng root extract for any indication. Manufacturers and experts were contacted to provide additional information. There were no restrictions regarding the language of publication. The outcome and methodological quality of all trials were independently assessed by two reviewers. Results: Sixteen trials met the inclusion criteria and were reviewed. These trials related to physical performance, psychomotor performance and cognitive function, immunmodulation, diabetes mellitus and herpes simplex type-II infections. The evidence found for ginseng root extract is compelling for none of these indications. Conclusion: Based on these data, it is concluded that the efficacy of ginseng root extract is not established beyond reasonable doubt for any of these indications. The widespread use of ginseng as a herbal remedy warrants more rigorous investigations to assess its efficacy and safety.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002280050674
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  • 2
    Digitale Medien
    Digitale Medien
    Acute effects of intravenous nisoldipine on left ventricular function after acute myocardial infarction (1994)
    Springer
    Cardiovascular drugs and therapy 8 (1994), S. 345-351 
    Details
    ISSN: 1573-7241
    Schlagwort(e): nisoldipine ; acute myocardial infarction ; myocardial stunning ; left ventricular function ; radionuclide angiography
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Nisoldipine is a calcium antagonist with potent coronary vasodilating effects in patients with chronic stable angina pectoris. In an initial study we showed that intravenous nisoldipine, given 24–72 hours after uncomplicated myocardial infarction, was a safe and feasible intervention that had beneficial effects on global and regional myocardial function. We subsequently studied the acute effects of nisoldipine in six patients within 24 hours (mean 14±4 hours) after the onset of myocardial infarction. Nisoldipine was administered as a 4.5 µg/kg intravenous bolus over 3 minutes, followed by intravenous infusion of 0.2 µg/kg over 60 minutes. Radionuclide angiography, cardiac output, and intraarterial blood pressure measurements were performed before and during nisoldipine. Left ventricular ejection fraction increased from 48.3±10.3% to 55.3±11.8% (p=0.034) during nisoldipine infusion. Regional wall motion score changed during nisoldipine infusion from 3.3±2.5 to 1.8±2.6 (p=0.027). Cardiac output increased from 5.5±1.0 to 7.3±1.3 1/min (p=0.0001). I eart rate increased from 78±12 to 88±11 min−1 (p=0.004). Mean arterial blood pressure decreased from 92±20 to 79±13 mmI g (p=0.038). The rate-pressure product did not change significantly during nisoldipine infusion. It is concluded that nisoldipine improves global and regional left ventricular function in patients with acute myocardial infarction within the first 24 hours.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00877319
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  • 3
    Digitale Medien
    Digitale Medien
    The acute effects of intravenous nisoldipine on left ventricular function 24 to 72 hours after uncomplicated acute myocardial infarction (1988)
    Springer
    Cardiovascular drugs and therapy 2 (1988), S. 673-678 
    Details
    ISSN: 1573-7241
    Schlagwort(e): nisoldipine ; acute myocardial infarction ; left ventricular function ; radionuclide angiography ; echocar-diography
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The acute effects on left ventricular function of nisoldipine were studied in six patients 56±12 hours (range 44 to 72 hours) after the onset of uncomplicated acute myocardial infarction. Nisoldipine was administered as a 4.5 μg/kg intravenous bolus over 3 minutes followed by an infusion of 0.2 μg/kg during 60 minutes. Radionuclide angiography and two-dimensional echocardiography were performed before and during infusien with nisoldipine. The left ventricular ejection fraction increased significantly from 38%±10% to 49%±10% (P=0.028) during nisoldipine infusion. Regional wall motion index was determined both by radionuclide and by two-dimensional echocardiography and showed a significant change during nisoldipine infusion from 1.9±0.3 to 1.5±0.3 (p=0.028, radionuclide angiography) and from 0.7±0.2 to 0.3±0.2 (p=0.043, two dimensional echocardiography). Heart rate increased significantly from 78±12 min-1 to 92±13 min-1 (p=0.028), but mean double product did not change significantly during nisoldipine infusion. It is concluded that nisoldipine significantly improves global and regional left ventricular function in patients shortly after acute myocardial infarction. This beneficial effect may, however, be partially offset by an increase in heart rate. Since mean double product did not change, it is suggested that nisoldipine may improve coronary blood flow in patients with acute myocardial infarction.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00054208
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  • 4
    Digitale Medien
    Digitale Medien
    Improved detection of acute myocardial infarction by magnetic resonance imaging using Gadolinium-DTPA (1989)
    Springer
    The international journal of cardiovascular imaging 5 (1989), S. 1-8 
    Details
    ISSN: 1573-0743
    Schlagwort(e): Magnetic Resonance Imaging ; acute myocardial infarction ; Gadolinium-DPTA ; contrast agents
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary To assess the value of the paramagnetic contrast agent Gadolinium (Gd)-DTPA in Magnetic Resonance Imaging (MRI) of acute myocardial infarction (AMI), we studied 20 patients with a first AMI by ECG-gated MRI before and after intravenous administration of 0.15mmol/kg Gd-DTPA. The MRI studies were performed after a mean of 98 hours (range 15–241) after the acute onset of AMI. Spin-echo measurements (TE 30 msec) were made using a Philips Gyroscan (0.5 Tesla). After performing the baseline MRI scans, the MRI procedure was repeated every 10 minutes for up to 40 minutes following injection of Gd-DTPA. In 18 (90%) patients contrast enhancement in the infarcted myocardial areas was observed after Gd-DTPA. In these patients intensity versus region curves, derived from 9 to 11 adjacent myocardial regions of interest, showed increased signal intensities in the infarcted areas after administration of Gd-DTPA. The precontrast signal intensity ratio between infarcted and normal myocardium was 1.14±0.15 (mean±SD); the postcontrast ratios at 10 minutes were 1.41±0.21 (P 〈0.05), at 20 minutes 1.61±0.19 (P 〈0.01), at 30 minutes 1.43±0.20 (P 〈 0.05), and at 40 minutes 1.33±0.20 (P=NS). It is concluded that MRI using the contrast agent Gd-DTPA significantly improves the visualization and detection of infarcted myocardial areas in patients with AMI and that optimal contrast enhancement is obtained 20 minutes after administration of Gd-DTPA.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01745226
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  • 5
    Digitale Medien
    Digitale Medien
    Usage of complementary therapies in rheumatology: A systematic review (1998)
    Springer
    Clinical rheumatology 17 (1998), S. 301-305 
    Details
    ISSN: 1434-9949
    Schlagwort(e): Alternative medicine ; Complementary medicine ; Costs ; Effectiveness ; Rheumatology ; Safety
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Complementary medicine (CM) is more popular than ever before. Rheumatology patients seem particularly keen to try CM. In this paper, surveys on rheumatology patients' use of CM are reviewed. The issues of perceived effectiveness, safety and costs are also addressed. In addition surveys of doctors' attitudes towards CM in rheumatology are summarised. Fourteen surveys on patients' use of CM and three on patients' attitudes towards CM were found and analysed. The results imply that the prevalence of CM varies between 30% and nearly 100%. Overall, patients perceive CM as being moderately effective. The survey contains only few data on adverse events of CM as perceived by these patients; collectively they suggest that adverse events are uncommon. Data on costs are similarly sparse; they imply that expenditure for CM is rarely high. Physicians seem to be more sceptical about CM than are their patients. It is concluded that, on average, CM is frequently used by rheumatology patients. The patients' level of satisfaction with CM is often considerable and few adverse effects are being reported. On the basis of these findings, a rigorous investigation of the effectiveness, safety and costs of CM in rheumatology seems desirable.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01451009
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