ISSN:
1432-1912
Keywords:
Differences in Age
;
Stereotypies
;
Body Temperature
;
Body Weight
;
Amphetamine Concentration in Liver and Brain
;
Acute and Chronic Experiments
;
Altersdifferenzen
;
Stereotypien
;
Körpertemperatur
;
Körpergewicht
;
Amphetaminkonzentration in Leber und Gehirn
;
akuter und chronischer Versuch
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The effect of a single or chronic administration of amphetamine on body temperature, extrapyramidal motor activity and body weight has been studied in young and old adult rats. The central nervous effects have been related to the content of amphetamine in brain and liver tissue taking account of time, dosage and the method of administration. The concentration of corticosterone in plasma under the influence of amphetamine has also been determined. The absorption of amphetamine from subcutaneous tissue is delayed, and its elimination is retarded in old animals when compared with young rats. Old rats react more sensitively after the injection of amphetamine than young ones, for, although there is a lower content of amphetamine to be found in the central nervous system, the stereotypy lasts longer and the rise in temperature is comparatively greater. On the other hand the increase in the corticosterone concentration in the serum of old rats is not as great as that seen in the serum of young rats. In chronic experiments the determination of amphetamine in liver and brain tissue gave no indication whether an accumulation or an accelerated metabolism by enzym induction was occurring. Furthermore no decrease in the response to amphetamine, e.g. a kind of tachyphylaxy or tolerance development, could be noticed during the experiments. For the total duration of the studies the differences in the effects of amphetamine on temperature and stereotypy in young and old rats were as great as the differences registered in the acute-experiments. Examination of body weight showed a difference which was dependent on age. While young rats increase in weight similar to untreated controls, old rats lose weight under the same conditions.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00997093
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