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  • 1
    Electronic Resource
    Electronic Resource
    Effects of taurine depletion on cell migration and NCAM expression in cultures of dissociated mouse cerebellum and N2A cells (1998)
    Springer
    Amino acids 15 (1998), S. 77-88 
    Details
    ISSN: 1438-2199
    Keywords: Amino acids ; Taurine ; Neurons ; NCAM ; Migration ; Transcription
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cultures of dissociated cerebellum from 5- to 6-day-old mice as well as of the N2A neuronal cell line were exposed to guanidino ethane sulfonate (GES, 2–5 mM) to reduce the cellular taurine content. Control cultures were kept in culture medium or medium containing 2–5 mM GES plus 2–5 mM taurine to restore the intracellular taurine content. Taurine depletion led to changes in the expression of certain splice variants of NCAM mRNA such as the AAG and the VASE containing forms, while no differences were seen in the expression of the three forms of NCAM protein. In the N2A cells taurine depletion led to a decreased migration rate of the cells. The results suggest that the reduced migration rate of neurons caused by taurine depletion may be correlated to changes in expression of certain adhesion molecules such as NCAM. Moreover, taurine appears to be involved in regulation of transcription processes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01345281
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  • 2
    Electronic Resource
    Electronic Resource
    Fracture of long bones: Rate effects under singular and combined loading states (1983)
    Hoboken, NJ [u.a.] : Wiley-Blackwell
    Journal of Orthopaedic Research 1 (1983), S. 244-250 
    Details
    ISSN: 0736-0266
    Keywords: Fracture behavior ; Axial-torsional loading ; Life and Medical Sciences
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: This study was undertaken to determine the effect of loading rate on bone failure under singular and combined loading states. Using the entire loading range of an Instron Materials Testing Machine, 190 pairs of canine radii were tested. One bone of each pair was subjected to either torsional or a combination of axial and torsional loads, and compared with a control specimen. Compressive loads of 4.6 and 11.5 N were utilized. Torque to failure and energy data versus loading rate were plotted. As loading rate increased, the torque and energy values were found to increase, reach a peak, and then decline at higher rates. Fractures produced under the combined state of loading are representative of those clinically found in human trauma situations.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jor.1100010303
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    Paper (German National Licenses)
    Fulltext
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