ISSN:
1573-7284
Keywords:
Hepatitis B virus
;
Hepatitis B vaccine
;
Intradertnal vaccination
;
Low dose
;
Mentally retarded
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Sixty-two patients of two institutions for mentally retarded patients were immunized intradermally with 4 ug doses of plasma-derived hepatitis B vaccine made in Japan, initially at month 0,1, and 6. The three vaccinations induced antibodies in 93.5% (90.9% in those with Down's syndrome (DS), 94.1% in other forms of mental retardation (OMR)) of the vaccinees within 9 months after the first injection, and the percentage of geometric mean titers of antibody above 10 mIU/ml was 89.3% (81.8% DS, 84.3% OMR) within 9 months. Within 2 years, the seroconversion rate showed a significantly higher decrease in subjects with DS (54.5%) than in OMR (86.3%), and the percentage of vaccinees with above 10 mIU/ml also showed a significantly higher decrease in subjects with DS (36.4%) than in those with OMR (74.5%) (p 〈 0.05). In the OMR patients, the antibody response persisted for 2 years, decreased remarkedly in the DS patients.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00218676
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