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  • Amino-oxyacetic acid  (1)
  • Chlorpromazine  (1)
  • Imipramine  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 95 (1988), S. 99-102 
    ISSN: 1432-2072
    Keywords: Amobarbital ; Amitriptyline ; Anxiety ; Body temperature ; Chlordiazepoxide ; Chlorpromazine ; Diazepam ; Haloperidol ; Imipramine ; Ipsapirone ; Meprobamate ; Tranylcypromine ; TVX Q 7821 ; Ultrasonic calling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The influence of a range of commonly used psychotherapeutic drugs on the ultrasonic calling of mouse pups was assessed. The major tranquilizers chlorpromazine and haloperidol were without effect. Whereas tranylcypromine and imipramine were also inactive, amitriptyline suppressed the rate of calling. Some anxiolytic compounds such as meprobamate and amobarbital were without influence, although others such as diazepam, chloridazepoxide and ipsapirone decreased the number of calls. The influence of these drugs on body temperature was measured, as it is known to markedly influence the rate of ultrasonic calling. Although six out of ten drugs decreased body temperature, there was no evidence that this was related to the rate of ultrasonic calling. The possibility that the recording of ultrasonic calls could be used to screen for psychotropic activity is discussed.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 49 (1976), S. 85-89 
    ISSN: 1432-2072
    Keywords: Amino-oxyacetic acid ; Gamma-aminobutyric acid ; Alpha-methyl-p-tyrosine ; Parachloro-phenylalanine ; Rat behavior
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Previous work has reported behavioural arousal in the rat to be inversely related to cortical GABA production. Therefore the effects of an increase in brain GABA levels, induced by amino-oxyacetic acid, on measures of behavioural arousal such as rearing and ambulation were examined. The increase in GABA was immediately associated with decreased rearing, however the behaviour was later indistinguishable from control values while the levels of brain GABA remained raised. It was suggested that the return to normal behaviour that occurred while brain GABA levels were increased, reflected an interaction between excitatory and inhibitory systems, and that a compensation had occurred to return the balance to normal. The pre-treatment with α-methyl-p-tyrosine, known to deplete brain noradrenaline and dopamine, prevented the characteristic return of normal behaviour that followed the injection of amino-oxyacetic acid. This data is consistent with GABA and noradrenaline or dopamine-mediated systems interacting in the control of behavioural arousal. The depletion of serotonin with p-chloro-phenylalanine did not prevent the characteristic recovery of behaviour that followed the injection of amino-oxyacetic acid.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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