ISSN:
1432-0533
Keywords:
Creutzfeldt-Jakob disease
;
Amyloid angiopathy
;
Prion protein
;
Immunohistochemistry
;
Experimental transmission
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary It was difficult to make a definite pathological diagnosis in a 73-year-old man with Creutzfeldt-Jakob disease (CJD) due to extensive amyloid angiopathy which lacked any severe spongiform changes. Immunostaining using anti-prion protein (PrP) antibody revealed fine granular deposits in the gray matter, after hydrolytic autoclaving pretreatment on tissue sections. Western blotting also revealed an abnormal isoform of PrP, but PrP gene analysis did not show any abnormalities. The primary transmission experiments were repeated three times and induced spongiform encephalopathy in a few mice after a long incubation period.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00310037
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