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  • 1
    Electronic Resource
    Electronic Resource
    Detection of an Amadori product, 1-hexitol-lysine, in the anterior horn of the amyotrophic lateral sclerosis and spinobulbar muscular atrophy spinal cord: evidence for early involvement of glycation in motoneuron diseases (2000)
    Springer
    Acta neuropathologica 99 (2000), S. 63-66 
    Details
    ISSN: 1432-0533
    Keywords: Key words Glycation ; Amadori product ; Amyotrophic lateral sclerosis ; Spinobulbar muscular atrophy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Glycation is a series of non-enzymatic reactions initiated by addition of reducing sugars to ɛ-amino group of lysine residues and α-amino group of the N terminus of proteins, leading to the formation of advanced glycation end products (AGE). It is thought to be involved in aging and various neurodegenerative conditions. In the present study using anti-1-hexitol-lysine (1-HL) antibody, Amadori product, an early glycation product, was detected in axonal spheroids in the anterior horn of amyotrophic lateral sclerosis and in atrophic neurons of spinobulbar muscular atrophy (SBMA, Kennedy disease with abnormally expanded triplet repeats in androgen receptor gene) but not in other regions of the central nervous system. Furthermore, Amadori product was undetectable in the tissues from age-matched controls. Thus, 1-HL formation could not reflect physiological aging.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00007407
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  • 2
    Electronic Resource
    Electronic Resource
    Plasma nitriding of Fe-18Cr-9Ni in the range of 723–823 K (1991)
    Springer
    Oxidation of metals 36 (1991), S. 143-156 
    Details
    ISSN: 1573-4889
    Keywords: plasma nitriding ; Fe-18Cr-9Ni ; CrN precipitates ; nitrogen diffusion ; kinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract To clarify the mechanism of plasma nitriding, we examined the optical microstructure, the hardness, the precipitation, and the concentration of dissolved nitrogen in Fe-18Cr-9Ni nitrided using plasma in the range of 723–823 K. Compared with ammonia-gas nitriding, the features of plasma nitriding are the formation of small chromium-nitride precipitates (CrN), the absence of an externally nitrided layer, the high concentration of dissolved nitrogen, and the high hardness (HV=1200). The diffusion coefficient of nitrogen in the present alloy was determined using the growth rate of the internally nitrided layer, based on calculations used in internal oxidation. Plasma- and gas-nitriding were also compared with respect to the growth rate of the nitrided layer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00938459
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    Paper (German National Licenses)
    Fulltext
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