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  • 1
    Electronic Resource
    Electronic Resource
    Therapy of childhood acute myelogenous leukemias (1996)
    Springer
    Annals of hematology 73 (1996), S. 11-24 
    Details
    ISSN: 1432-0584
    Keywords: Key wordsChildhood acute myelogenous leukemia ; Cytosine arabinoside ; Anthracyclines ; Bone marrow transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Acute myelogenous leukemia (AML) accounts for approximately 20% of acute leukemias in children. Although AML is more resistant to chemotherapy than acute lymphoblastic leukemia (ALL), significant progress in improving outcome for AML patients has been achieved over the past 15 years. This can be attributed to intensification of chemotherapy, increased use of bone marrow transplantation, and improved supportive care. Thus 30–50% of children with AML achieve long-term event-free survival with current treatment strategies [61, 66, 85, 96]. This review gives an overview about the evolution of and rationale for current pediatric treatment protocols, with special emphasis on the German Berlin-Frankfurt-Münster (BFM) studies, and discusses new directions for the future.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050193
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Blood sampling in very low birth weight infants receiving different levels of intensive care (1988)
    Springer
    European journal of pediatrics 147 (1988), S. 399-404 
    Details
    ISSN: 1432-1076
    Keywords: Anaemia, non-physiological ; preterm infant ; Diagnostic blood sampling ; Blood transfusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Sixty very low birth weight infants (birth weight 560–1450g) were studied during the first 28 days of life. The infants were classified as group A (n=19 infants who never required ventilator support), group B (n=20 infants mechanically ventilated for minor respiratory problems), and group C (n=21 infants ventilated for respiratory distress syndrome). Diagnostic blood sampling was measured, infants were checked for clinical symptoms and laboratory signs of anaemia 24 h before and after the transfusion of packed red cells. A total of 7998 punctures (average: 4.8 per infant per day) were performed, the mean blood loss due to diagnostic sampling was 50.3 ml/kg per 28 days (range 7–142) for all infants. A high correlation (r s=+0.91) was found between the blood volumes sampled and transfused. In group A, the mean blood loss was 24 ml/kg, and a total of 29 blood transfusions were administered. The most frequent symptoms of anaemia were poor weight gain and apnoeic spells. In group B, the mean blood loss was 60 ml/kg and a total of 97 blood transfusions were administered. In group C, the mean blood loss was 67 ml/kg and a total of 116 blood transfusions were administered. In both groups B and C, poor weight gain, pallor and distended abdomen were the most frequent symtoms of anaemia. Following the blood transfusion, haematocrit rose and blood pressure remained unchanged. The symptoms that responded most favourably to the blood transfusion were: poor weight gain, oxygen requirement, and distended abdomen. The results emphasize the need for miniaturizing laboratory techniques and monitoring blood sampling.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00496419
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  • 3
    Electronic Resource
    Electronic Resource
    Benzokondensierte 7-Ring-Heterocyclen, VI. Schmidt-Reaktion an 1-Thio-chromanonen-(4) und 1-Thio-chromanon-(4)-1.1-dioxiden (1970)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 103 (1970), S. 2302-2307 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Benzo-fused Seven-membered Heterocyclic Compounds, VI. Schmidt Reaction on 1-Thio-4-chromanones and 1-Thio-4-chromanone 1.1-DioxidesThe Schmidt reaction on 1-thio-4-chromanones (1) leeds to 1,4- and/or 1,5-benzothiazepinones (2 or 4), depending on further substituents in the aromatic ring system: electron acceptors favouring migration of the aryl group. 1 - Thio-4-chromanone S.S-dioxides (5) with hydrazoic acid only yield 1.5-benzothiazepine derivatives (6).
    Notes: Die Schmidt-Reaktion an 1-Thio-chromanonen-(4) (1) führt in Abhängigkeit von den Substituenten am Benzolring zu 1.4- und/oder 1.5-Benzothiazepinonen (2 bzw. 4), wobei Elektronenacceptoren die Wanderung der Arylgruppe begünstigen. 1-Thio-chromanon-(4)-S.S-dioxide (5) ergeben mit Stickstoffwasserstoffsäure ausschließlich 1.5-Benzothiazepin-Derivate (6).
    Additional Material: 6 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19701030736
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  • 4
    Electronic Resource
    Electronic Resource
    Über Antamanid, XI. Merrifield-Synthese Tyrosin-haltiger Analoga des Antamanids (1972)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 757 (1972), S. 136-146 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Antamanide, XI. - Merrifield Synthesis of Tyrosine-containing Analogues of AntamanideAnalogues of antamanide (AA) in which the phenylalanines in positions 5, 6, 9 and 10 are replaced by tyrosine are synthesized by punched tape programmed automatic synthesis on polystyrene resins. Tyrosine is used as its O-benzyl derivative: Tyr5-AA (1), Tyr6-AA (2), Tyr9-AA (3), Tyr10-AA (4), Ile1. Tyr6-AA (5), Ile1. Tyr5. Tyr10-AA (6), Gly1. Gly4. Tyr5-AA (7), Gly1. Gly4. Tyr6-AA (8), and Tyr9. de-Ala-AA (9). The cyclopeptides 1, 2 and 5 like AA protect in a dose of 0.5-1 mg per kg the white mouse from being killed by 5 mg phalloidine per kg, the analogue 3 with 2 mg per kg; 4 and 6 have the same effect with 5 mg per kg and the glycine-containing tyrosine-antamanides 7 and 8 are ineffective even with 20 mg per kg. The cyclononapeptide 9 without Ala4 of the antamanide sequence is found to be the first effective shortened analogues of AA with a protecting dose of 5-10 mg per kg.
    Notes: Analoge des Antamanids (AA), in denen die Phenylalanine der Positionen 5, 6, 9 und 10 durch Tyrosin ersetzt sind, werden durch Lochstreifen-programmierte, automatische Synthese der linearen Decapeptide-Vorstufen an Polystyrolharzen unter Verwendung von O-Benzyl-tyrosin aufgebaut und zwar: Tyr5-AA (1), Tyr6-AA (2), Tyr9-AA (3), Tyr10-AA (4), Ile1. Tyr6-AA (5), Ile1. Tyr5. Tyr10-AA (6), Gly1. Gly4. Tyr5-AA (7), Gly1. Gly4. Tyr6-AA (8), und Tyr9. des-Ala-AA (9). Die Cyclopeptide 1, 2 und 5 schützen wie Antamanid mit ca. 1 mg pro kg die weiße Maus vor dem Tod durch 5 mg Phalloidin pro kg, die Variante 3 mit 2 mg pro kg; 4 und 6 wirken mit 5 mg pro kg, während die Glycin-haltigen Tyrosin-Antamanide 7 und 8 noch mit 20 mg pro kg unwirksam sind. Im Cyclononapeptid 9, dem das Ala4 der Antamanidsequenz fehlt, liegt das erste wirksame, verkürzte Antamanid-Analog vor; es schützt die Maus bei einer Dosis von 5-10 mg pro kg.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.19727570115
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  • 5
    Electronic Resource
    Electronic Resource
    Der α.α-Dimethyl-3.5-dimethoxybenzyloxycarbonyl (Ddz)-Rest, eine photo- und säurelabile Stickstoff-Schutzgruppe für die PeptidchemieAuszugsweise vorgetragen auf dem XI. Europäischen Peptidsymposium in Wien, 26. bis 30. April 1971. (1972)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 763 (1972), S. 162-172 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: The α,α-Dimethyl-3,5-dimethoxybenzyloxycarbonyl (Ddz) Residue, an N-Protecting Group Labile toward Weak Acids and IrradiationThe synthesis of α,α-dimethyl-3,5-dimethoxybenzyloxycarbonyl azide (7) and its reactions with several amino acids are described. It is shown that the N-acyl residue can easily be cleaved from the Ddz-amino acids under weakly acidic conditions. Moreover it is possible to eliminate the protecting group by UV-irradiation in a continuous procedure without side reactions. Fission products of the acyl residue are isolated and identified.
    Notes: Die Synthese des α.α-Dimethyl-3.5-dimethoxybenzyloxycarbonylazids (7) und seine Umsetzung mit einer Reihe von Aminosäuren zu den Ddz-aminosäuren wird beschrieben. Es wird gezeigt, daß der neue N-Acyl-Rest leicht unter schwach sauren Bedingungen abgespalten werden kann. Außerdem ist es möglich, die Schutzgruppe in einem kontinuierlichen Verfahren durch Bestrahlung mit UV-Licht ohne Nebenreaktionen zu entfernen; dabei entstehende Spaltstücke der Schutzgruppe werden isoliert und identifiziert.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.19727630118
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  • 6
    Electronic Resource
    Electronic Resource
    A Novel Entry to Corticoids (1981)
    Weinheim : Wiley-Blackwell
    Angewandte Chemie International Edition in English 20 (1981), S. 88-89 
    Details
    ISSN: 0570-0833
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/anie.198100881
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    Paper (German National Licenses)
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