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  • Anaerobic glycolysis  (2)
  • Cytogenetics  (2)
  • Glomerular thrombosis  (2)
  • Hyperplasia  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Design of the mammalian respiratory system. II. Measuring maximum aerobic capacity
    Amsterdam : Elsevier
    Respiration Physiology 44 (1981), S. 11-23 
    Details
    ISSN: 0034-5687
    Keywords: Allometry ; Anaerobic glycolysis ; Cold exposure ; Exercise ; Lactate ; Oxygen consumption
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0034-5687(81)90074-8
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Design of the mammalian respiratory system. III. Scaling maximum aerobic capacity to body mass: Wild and domestic mammals
    Amsterdam : Elsevier
    Respiration Physiology 44 (1981), S. 25-37 
    Details
    ISSN: 0034-5687
    Keywords: African mammals ; Allometry ; Anaerobic glycolysis ; Oxygen consumption
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0034-5687(81)90075-X
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Role of nitric oxide in a toxin-induced model of haemolytic uraemic syndrome (2000)
    Springer
    Pediatric nephrology 14 (2000), S. 1066-1070 
    Details
    ISSN: 1432-198X
    Keywords: Key words Haemolytic uraemic syndrome ; Ricin ; Verocytotoxin ; Nitric oxide ; Cytokines ; Glomerular thrombosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The role of nitric oxide in the pathogenesis of glomerular thrombotic microangiopathy was explored using an established rat model in which ricin with or without lipopolysaccharide induced glomerular thrombosis. Ricin alone caused a small rise in the plasma concentration of nitric oxide (control 9.2±0.7 µM, ricin 23.3±6.3 µM at 7 h). This increase occurred after the development of glomerular thrombosis. Nitric oxide synthase (NOS) activity in the kidney showed no significant change from control values (control 5.66±2.7 pmol/min per ml homogenate, ricin 7.52±1.8 pmol/min per ml homogenate, total activity). When ricin and lipopolysaccharide were administered together, calcium-independent NOS activity increased whereas calcium-dependent activity decreased (1.22±2.6 pmol/min per ml homogenate). The increase in calcium-independent NOS activity correlated with a high plasma concentration of interleukin-1β in the ricin plus lipopolysaccharide group (4,036.83±1,001.5 pg/ml). These data indicate that thrombus formation in a rat model of haemolytic uraemic syndrome is independent of the effects of nitric oxide.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004670000388
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Renal histopathology in fatal cases of diarrhoea-associated haemolytic uraemic syndrome (1997)
    Springer
    Pediatric nephrology 11 (1997), S. 556-559 
    Details
    ISSN: 1432-198X
    Keywords: Key words: Haemolytic uraemic syndrome ; Glomerular thrombosis ; Arteriolar thromboses ; Neutrophils
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract.  Autopsy material was examined from British children dying early in the course of haemolytic uraemic syndrome (HUS). These presented after 1983, the period in which verocytotoxin-producing Escherichia coli (VTEC) infection was confirmed as the leading cause of diarrhoea-associated (D+HUS) in the United Kingdom. Of 18 cases referred for this study, 3 were found on review to have no history of a diarrhoeal prodrome (D-HUS). In the D+ patients, the median duration from onset of diarrhoea to death was 8 days (range 4–42 days). VTEC infection was confirmed in 6 cases. All had neutrophilia at presentation (median 21, range 15–49.8 × 109/l). The 15 cases had uniform pathological features, consisting of glomerular thromboses and congested rather than ischaemic glomeruli. Arteriolar thromboses were common at the hilum of glomeruli and were sometimes also seen proximally, including in interlobular arteries. There were cortical infarcts in 5 cases with extensive thrombosis. Cases were demonstrated to have significantly greater numbers of neutrophils expressed per 100 glomeruli than controls, when counted using immunohistological stains to neutrophil elastase and CD15. This study showed uniformity of the renal changes in D+ HUS and gave further evidence of the importance of neutrophils in the pathogenesis of the disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004670050337
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Comparison of differentiation patterns in 12-O-tetradecanoylphorbol-13-acetate-treated epidermis and fetal epidermis (1985)
    Springer
    Archives of dermatological research 277 (1985), S. 457-465 
    Details
    ISSN: 1432-069X
    Keywords: Epidermis ; Hyperplasia ; TPA ; Stereology ; Morphometry ; Tumor promotors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 12-O-Tetradecanoylphorbol-13-acetate (TPA)-treated adult epidermis as well as untreated fetal and adult epidermis were investigated to elucidate the effect of TPA in terms of cell differentiation using techniques of ultrastructural stereology. Twenty-four hours after a single application of TPA, the treated epidermis was characterized by involutional changes, i. e., increased volume density of intercellular spaces and of mitochondria, vacuoles, and cytoplasmic ground substance in the basal layer. However, 48 h after application, the TPA-treated epidermis was very similar to fetal epidermis, i. e., high volume density of nuclei ribosomes, rough endoplasmic reticulum, membrane-coating granules, and keratohyalin granules, and low volume density of bundled filaments in the upper layers. These stereological data indicate that the changes observed 48 h after TPA treatment were related not only to increased cell proliferation but also to inhibition of cell differentiation expressed as a reversion of the adult differentiation patterns and the acquisition of fetal characteristics in all epidermal layers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00510063
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Contribution of immunophenotypic and genotypic analyses to the diagnosis of acute leukemia (1995)
    Springer
    Annals of hematology 71 (1995), S. 13-27 
    Details
    ISSN: 1432-0584
    Keywords: Acute leukemia ; Diagnosis ; Immunophenotypic ; Cytogenetics ; Molecular genetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Diagnostic accuracy in acute leukemia (AL) can be improved if traditional morphology and cytochemistry are supplemented with immunophenotypic and genotypic analyses. This multiparameter approach is of crucial importance for the management of patients, as it enables the identification of leukemic syndromes with distinct biological features and response to treatment. Immunophenotyping using monoclonal antibodies has been universally accepted as a useful adjunct to morphological criteria. This technique is particularly valuable in diagnosing and subclassifying acute lymphoblastic leukemia and is also essential in certain types of acute myeloid leukemia (AML), such as AML with minimal differentiation or acute megakaryoblastic leukemia. Cytogenetic findings can be quite helpful in establishing the correct diagnosis and can add information of prognostic significance. A number of specific chromosomal abnormalities have been recognized that are very closely, and sometimes uniquely, associated with morphologically and clinically distinct subsets of leukemia. An even more basic understanding of normal and malignant hematopoietic cells has begun to evolve as molecular biology begins to unravel gene misprogramming by Southern and Northern blot analysis, the polymerase chain reaction, and fluorescence in situ hybridization. With the extensive use of these techniques it has become apparent that a proportion of leukemias exhibit the biologically relevant molecular defect in the absence of a karyotypic equivalent. On the other hand, apparently uniform chromosomal abnormalities such as the t(1;19) (q23;p13), t(9;22) (q33;q11), t(8;14) (q24;q32), or t(15;17) (q21;q21) may differ at the molecular level. Data collected from these modern technologies have introduced a greater complexity, which needs to be taken into consideration to improve both the diagnostic precision and the reproducibility of current classifications.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01696228
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Contribution of immunophenotypic and genotypic analyses to the diagnosis of acute leukemia (1995)
    Springer
    Annals of hematology 71 (1995), S. 13-27 
    Details
    ISSN: 1432-0584
    Keywords: Key words Acute leukemia ; Diagnosis ; Immunophenotypic ; Cytogenetics ; Molecular genetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Diagnostic accuracy in acute leukemia (AL) can be improved if traditional morphology and cytochemistry are supplemented with immunophenotypic and genotypic analyses. This multiparameter approach is of crucial importance for the management of patients, as it enables the identification of leukemic syndromes with distinct biological features and response to treatment. Immunophenotyping using monoclonal antibodies has been universally accepted as a useful adjunct to morphological criteria. This technique is particularly valuable in diagnosing and subclassifying acute lymphoblastic leukemia and is also essential in certain types of acute myeloid leukemia (AML), such as AML with minimal differentiation or acute megakaryoblastic leukemia. Cytogenetic findings can be quite helpful in establishing the correct diagnosis and can add information of prognostic significance. A number of specific chromosomal abnormalities have been recognized that are very closely, and sometimes uniquely, associated with morphologically and clinically distinct subsets of leukemia. An even more basic understanding of normal and malignant hematopoietic cells has begun to evolve as molecular biology begins to unravel gene misprogramming by Southern and Northern blot analysis, the polymerase chain reaction, and fluorescence in situ hybridization. With the extensive use of these techniques it has become apparent that a proportion of leukemias exhibit the biologically relevant molecular defect in the absence of a karyotypic equivalent. On the other hand, apparently uniform chromosomal abnormalities such as the t(1;19) (q23;p13), t(9;22) (q33;q11), t(8;14) (q24;q32), or t(15;17) (q21;q21) may differ at the molecular level. Data collected from these modern technologies have introduced a greater complexity, which needs to be taken into consideration to improve both the diagnostic precision and the reproducibility of current classifications.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01696228
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Evidence of fibre hyperplasia in human skeletal muscles from healthy young men? (1991)
    Springer
    European journal of applied physiology 62 (1991), S. 301-304 
    Details
    ISSN: 1439-6327
    Keywords: Muscle ; Muscle fibres ; Histocytochemistry ; Hyperplasia ; Handedness
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cross-sections (thickness 10 μm) of whole autopsied left and right anterior tibialis muscles of seven young previously healthy right-handed men (mean age 23 years, range 18–32 years) were prepared for light-microscope enzyme histochemistry. Muscle cross-sectional area and total number of fibres, mean fibre size (indirectly determined) and proportion of the different fibre types (type 1 and type 2 on basis of myofibrillar adenosine triphosphatase characteristics), in each muscle cross-section were determined. The analysis showed that the cross-sectional area of the left muscle was significantly larger (P〈0.05), and the total number of fibres was significantly higher (P〈0.05), than for the corresponding right muscle. There was no significant difference for the mean fibre size or the proportion of the two fibre types. The results imply that long-term asymmetrical low-level daily demands on muscles of the left and the right lower leg in right-handed individuals provide enough stimuli to induce an enlargement of the muscles on the left side, and that this enlargement is due to an increase in the number of muscle fibres (fibre hyperplasia). Calculations based on the data also explain why the underlying process of hyperplasia is difficult, or even impossible, to detect in standard muscle biopsies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00634963
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    Paper (German National Licenses)
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