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  • MHC  (2)
  • Anaerobic work capacity  (1)
  • Analysis  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Calcified tissue international 4 (1969), S. 314-329 
    ISSN: 1432-0827
    Keywords: Sponge ; Spicules ; Calcite ; Analysis ; Specific gravity ; Speciation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Description / Table of Contents: Résumé Nous donnons les résultats d'analyses chimiques, d'examens aux rayons infra-rouge, et d'examens par diffraction des rayons-X, des spicules de sept espèces des Éponges Calcaires avec aussi les valeurs de gravité spcéifique. Les spicules se composent de calcite et de magnésium. Nous avons découvert des traces de quartz, mais nous les attribuons à la contamination. Nous avons cherché l'aragonite, sans la trouver, bien que la présence du quartz en rende plus difficile la recherche. Le contenu de Mg2+ a varié de 1,25 à 3,15 pour cent d'une espèce à l'autre, s'élevant selon la grandeur des spicules dans les deux espèces que nous avons étudiées. Il était aussi en corrélation étroite avec le déplacement du sommet 112 de diffraction. Des composants présents en quantité moindre, et dont nous avons estimé le pourcentage, se trouvaient être Sr2+, Na+ et SO 4 2− . Sr2+ était relativement invariable, les deux autres étaient variables. Nous avons découvert aussi des traces de Al3+, Si, Mn2+, Ba2+ et Li+. Les valeurs de gravité spécifique s'échelonnaient de 2,58 à 2,62, les spicules plus petits fournissant la plus grande variation. Nous considérons la composition par rapport à la sécrétion de spicules et à la classification de la Calcarea.
    Abstract: Zusammenfassung Die Ergebnisse von chemischen, röntgenographischen und infraroten Analysen, zusammen mit Bestimmungen von spezifischem Gewicht, werden für die Nadeln von 7 species der Kalkschwämme dargestellt. Die Nadeln setzen sich zusammen aus magnesiahaltigem Calcit. Spuren von Quartz wurden nachgewiesen, die sich aber auf Verunreinigungen zurückführen lassen. Aragonit wurde gesucht, aber nicht gefunden, obgleich die Anwesenheit von Quartz seine Feststellung erschwert. Der Mg2+-Inhalt variierte von 1,25–3,15% zwischen den Species, und nahm mit wachsender Nadelgröße bei den beiden untersuchten Species zu; es gibt auch enge Wechselbeziehungen zur Absetzung der Calcit-112-Diffraktionsspitze. Es gibt vermutlich geringere Mengen von Sr2+, Na+, und SO 4 2− . Sr2+ war relative beständig, die anderen zwei veränderlich. Spuren von Al3+, Si, Mn2+, Ba2+ und Li+ wurden auch nachgewiesen. Die durchschnittlichen spezifischen Gewichte veränderten sich von 2,58–2,62, und kleinere Nadeln variieren stärker. Die Zusammensetzung wird mit Hinsicht auf die Ausscheidung der Nadeln und die Klassenordnung der Kalkschwämme betrachtet.
    Notes: Abstract The results of chemical, X-ray diffraction and infra-red analyses, together with specific gravity determinations, are presented for the spicules of seven species of Calcarea. The spicules are composed of magnesian calcite. Traces of quartz were detected, but are ascribed to contamination. Aragonite was sought but not proven, although the presence of quartz complicates its detection. The Mg content varied from 1.25–3.15% between species, and increased with spicule size in the two species studied; it also correlated closely with the displacement of the calcite 112 diffraction peak. Minor constituents estimated were Sr2+, Na+ and SO 4 2− :Sr2+ was relatively constant, the other two variable. Traces of Al3+, Si, Mn2+ and Li+ were also detected. Average specific gravities ranged from 2.58–2.62, smaller spicules having a wider range Composition is considered in relation to spicule secretion and classification of the Calcarea.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0428
    Keywords: Diabetes mellitus ; Indian Asian ; MHC ; tumour necrosis factor ; linkage disequilibrium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Tumour necrosis factor gene polymorphism has been proposed as a determinant of Type 1 (insulin-dependent) diabetes mellitus. Tumour necrosis factor-beta gene polymorphisms were analysed in 40 North Indian Asian Type 1 diabetic patients and 63 control subjects. A 5.5 kilobase gene fragment was significantly increased among the patients (82.5% vs 52%, p c〈0.01). A 10.5 kilobase fragment was significantly reduced among the patients (70% vs 90.5%, p c〈0.02). The 5.5 kilobase fragment was associated with DR3, and was not significantly increased among DR3-positive patients compared with DR3-positive control subjects. The 5.5 kilobase/5.5 kilobase genotype was increased among the diabetic subjects (30% vs 9.5%, p c〈0.03). The 10.5 kilobase/10.5 kilobase genotype was reduced among the diabetic subjects (17.5% vs 47.5%, p c〈0.02). The 5.5 kilobase/10.5 kilobase genotype was not significantly associated with disease. These findings contrast with those in a white Caucasian population, suggesting that tumour necrosis factor-beta polymorphisms do not predispose to Type 1 diabetes directly, but are in linkage disequilibrium with disease susceptibility alleles at other MHC loci.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0428
    Keywords: Type 1 diabetes ; trans-racial studies ; DNA ; gene mapping ; HLA ; MHC
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A major component of inherited susceptibility to Type 1 (insulin-dependent) diabetes mellitus has been mapped to the major histocompatibility complex. Certain gene alleles in this region determine susceptibility and resistance to the disease. Mapping of susceptibility is hindered by the limitations of conventional tissue typing techniques, and by strong linkage disequilibrium within this part of the genome. Recombinant DNA technology and trans-racial studies have been used to allow finer mapping of genetic predisposition to Type 1 diabetes. These techniques have localised alleles encoding susceptibility and resistance to the DQ region. Other alleles determining disease susceptibility remain poorly localised.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European journal of applied physiology 71 (1995), S. 559-561 
    ISSN: 1439-6327
    Keywords: Critical power ; Anaerobic work capacity ; Methodology ; Electrically-braked ergometer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study examined the effect of end-point cadence on the parameters of the work-time relationship determined for cycle ergometry. Eight male subjects completed four maximal tests on an electrically-braked cycle ergometer that regulated a constant power output independent of cadence. The power outputs imposed ranged between an average of 259 W and 403 W, whereas the corresponding durations ranged between 139 s and 1691 s. During each test subjects were required to maintain a cadence of 80–90 rpm. Accumulated time to end-point cadences of 70, 60 and 50 rpm were recorded. The four work-time determinations for each of three end-point cadences were used to determine linear relationships between work and time, yielding both a y-intercept, which represents anaerobic work capacity, and a slope, which is termed critical power (CP), for each end-point cadence. There was a significant increase in the y-intercept as end-point cadence decreased from 70 to 60 rpm (F[1,7]=36.7, p 〈 0.001) or 70 to 50 rpm (F[1,7]=80.1, p 〈 0.001), but not from 60 rpm to 50 rpm (F[1,7]=3.28, p 〉 0.05). In contrast, there was no effect of end-point cadence on CP (F[2,14]=1.89, p 〈 0.05). These results demonstrate that the end-point cadence selected to terminate tests only affects the y-intercept of the work-time relationship. To control for this effect, the cadence at which each test is terminated should be standardised if determination of anaerobic work capacity, as represented by the y-intercept, is required.
    Type of Medium: Electronic Resource
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