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  • Type 1 (insulin-dependent) diabetes  (2)
  • Anaerobic work capacity  (1)
  • DNA adducts  (1)
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Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Mutation Research/Environmental Mutagenesis and Related Subjects 292 (1993), S. 113-122 
    ISSN: 0165-1161
    Keywords: Antibody ; DNA ; DNA adducts ; ELISA ; ^3^2P-postlabelling analysis ; anti-Benzo[a]pyrene-diol-epoxide-DNA antibody analysis
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0428
    Keywords: Type 1 (insulin-dependent) diabetes ; HLA-DQ ; racial studies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Type 1 (insulin-dependent) diabetic patients and control subjects of Afro-Caribbean Negroid racial origin were investigated by serological HLA-DR-typing and restriction fragment length polymorphism analysis using DNA probes corresponding to the DQα, DQβ and DRβ chain genes. Combined analysis indicated that four DR antigens are positively associated with the condition in Negroid subjects — DR3, 4, 7 and w9. DR3 and 4 are also associated in Caucasians, but the relative risk for DR3 is lower in Negroid subjects. The DR7 association is specific for the Negroid race, and DRw9 is only weakly associated in Caucasoid subjects. Restriction fragment length polymorphism analysis demonstrated a DQβ restriction pattern in Negroid subjects which is absent from Caucasoid subjects. This pattern was associated with DRw9 and a subset of DR7, and was markedly increased in frequency in diabetic patients compared with control subjects (48.7% vs 10.4%, respectively; P〈10−4). In the absence of this pattern, DR7 showed no positive association. DR3 in Negroid subjects was associated with two distinct DQα-DQβ patterns, only one of which was positively associated with diabetes. A DQβ pattern, in linkage disequilibrium with different DR antigens in different races, conferred a consistent protective effect against the development of Type 1 diabetes. Trans-racial genetic analysis thus supports a primary role for DQ in susceptibility to Type 1 diabetes.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0428
    Keywords: Trans-racial studies ; North Indians ; gene probing ; HLA-DQ ; Type 1 (insulin-dependent) diabetes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Trans-racial analysis of disease associations has improved mapping of MHC-linked susceptibility to Type 1 (insulin-dependent) diabetes mellitus. In this study the contributions of the MHC class II DQA1 and DQB1 genes were investigated. Sequence-specific oligonucleotide gene probing in Type 1 diabetic and control subjects of North Indian origin supported the DQw1.18 allele of the DQB1 gene as a determinant of inherited protection against Type 1 diabetes (RR=0.12, p c〈0.05). The A3 allele of the DQA1 gene was positively associated with the disease, (RR=3.6, p c〈0.05), as was the DQw2 allele of the DQB1 gene (RR=4.6, p c〈0.01). Trans-racial comparison of these disease associations indicates that DQ alleles may directly determine an element of inherited susceptibility to Type 1 diabetes.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European journal of applied physiology 71 (1995), S. 559-561 
    ISSN: 1439-6327
    Keywords: Critical power ; Anaerobic work capacity ; Methodology ; Electrically-braked ergometer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study examined the effect of end-point cadence on the parameters of the work-time relationship determined for cycle ergometry. Eight male subjects completed four maximal tests on an electrically-braked cycle ergometer that regulated a constant power output independent of cadence. The power outputs imposed ranged between an average of 259 W and 403 W, whereas the corresponding durations ranged between 139 s and 1691 s. During each test subjects were required to maintain a cadence of 80–90 rpm. Accumulated time to end-point cadences of 70, 60 and 50 rpm were recorded. The four work-time determinations for each of three end-point cadences were used to determine linear relationships between work and time, yielding both a y-intercept, which represents anaerobic work capacity, and a slope, which is termed critical power (CP), for each end-point cadence. There was a significant increase in the y-intercept as end-point cadence decreased from 70 to 60 rpm (F[1,7]=36.7, p 〈 0.001) or 70 to 50 rpm (F[1,7]=80.1, p 〈 0.001), but not from 60 rpm to 50 rpm (F[1,7]=3.28, p 〉 0.05). In contrast, there was no effect of end-point cadence on CP (F[2,14]=1.89, p 〈 0.05). These results demonstrate that the end-point cadence selected to terminate tests only affects the y-intercept of the work-time relationship. To control for this effect, the cadence at which each test is terminated should be standardised if determination of anaerobic work capacity, as represented by the y-intercept, is required.
    Type of Medium: Electronic Resource
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