ISSN:
1432-2072
Keywords:
Morphine
;
Analgesia
;
Tolerance
;
Apomorphine
;
Alpha-methyl-p-tyrosine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract In rats the development of one-trial tolerance to the analgesic action of i. p. administered morphine is disrupted by the postadministration of apomorphine (30 mg/kg at 5 min but not at 3 h) or alpha-methyl-p-tyrosine (200 mg/kg at 5 min and 3 h but not at 12 h). Diethyldithiocarbamate or propranol has no disruptive effect. It is suggested that development of tolerance to the analgesic effects of morphine is mediated by sequential time-dependent biochemical processes.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01457855
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