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  • Analytical Chemistry and Spectroscopy  (6)
  • Bullous pemphigoid  (5)
  • Nucleosides  (3)
  • 1
    Electronic Resource
    Electronic Resource
    An autoradiographic technique to evaluate in vitro produced autoantibodies by peripheral blood leucocytes of patients with bullous pemphigoid (1983)
    Springer
    Archives of dermatological research 275 (1983), S. 59-61 
    Details
    ISSN: 1432-069X
    Keywords: Autoradiography ; Peripheral blood leucocytes ; Pokeweed mitogen ; Bullous pemphigoid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00516557
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  • 2
    Electronic Resource
    Electronic Resource
    Suppressor-cell functions in bullous pemphigoid (1985)
    Springer
    Archives of dermatological research 277 (1985), S. 307-312 
    Details
    ISSN: 1432-069X
    Keywords: Bullous pemphigoid ; Immunoregulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary T Cells from 14 patients in the active stage of bullous pemphigoid and 10 patients in the inactive stage of the disease were studied with Leu-1, Leu-2, and Leu-3 monoclonal antibodies. The proportions of total T cells and T cells expressing either helper or suppressor phenotype in the peripheral blood of patients were not significantly different to those observed in normal subjects. In 15 patients with active disease, immunoregulatory mechanisms were functionally studied using an assay measuring the amount of total IgG synthesized in vitro. Peripheral-blood leukocytes were seearated into T- and B-cell fractions, and cultured in various combinations. In ten experiments, prior to culturing with B cells, the T cells were irradiated to remove their suppressor function. No statistically significant differences were observed in the amount of total IgG synthesized by B cells obtained from patients and normal subjects when they were cultured with untreated T cells or irradiated T cells obtained from patients or normal controls. These results indicate that, in patients with bullous pemphigoid, there is no loss of suppressor-cell function or increased helper-cell function as assessed by measuring the total IgG synthesized. Therefore, the immunoregulatory defect, if present, is a highly specific one and can only be studied using antigen-specific assays.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00509086
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  • 3
    Electronic Resource
    Electronic Resource
    Interleukin-2 production in bullous pemphigoid (1984)
    Springer
    Archives of dermatological research 276 (1984), S. 330-332 
    Details
    ISSN: 1432-069X
    Keywords: Interleukin 2 ; Bullous pemphigoid ; Autoimmunity ; Immune regulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00404627
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  • 4
    Electronic Resource
    Electronic Resource
    Lymphotoxin detected in the blister fluid of bullous pemphigoid patients (1984)
    Springer
    Journal of clinical immunology 4 (1984), S. 31-35 
    Details
    ISSN: 1573-2592
    Keywords: Bullous pemphigoid ; blisters ; lymphocytes ; lymphotoxin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The role of lymphocytes in the pathogenesis of bullous pemphigoid was examined by assaying the blister fluid obtained from bullous pemphigoid patients for the presence of the lymphokine, lymphotoxin. Blister fluids from six bullous pemphigoid were assayed on L-929 target cells for the presence of cytolytic molecules in the standard lymphotoxin assay. Three of six blister fluids obtained from bullous pemphigoid patients and one linear IgA bullous dermatosis patient contained significant levels of cytolytic activity. Control blister fluids from suction blisters, herpes, pemphigus, and toxic epidermal necrolysis patients did not contain cytolytic activity. Serum from five bullous pemphigoid patients also had no cytolytic activity. Neutralization studies using rabbit anti-α-lymphotoxin demonstrated that 54 to 88% of the cytolytic activity found in bullous pemphigoid blister fluid was due to α-lymphotoxin. These results indicate that lymphotoxin is locally released in the skin of bullous pemphigoid lesions and is detectable in blister fluids.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00915284
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  • 5
    Electronic Resource
    Electronic Resource
    Production of anti-basement membrane-zone antibody by peripheral blood leukocytes of bullous pemphigoid patients (1982)
    Springer
    Journal of clinical immunology 2 (1982), S. 179-185 
    Details
    ISSN: 1573-2592
    Keywords: Bullous pemphigoid ; basement membrane zone ; peripherial blood leukocytes ; autoimmunity ; immunoregulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Peripheral blood leukocytes (PBL) from patients with bullous pemphigoid stimulated by pokeweed mitogen (PWM) produce an anti-basement membrane-zone (BMZ) antibody. The antibody producedin vitro was biosynthetically radiolabeled, and its binding to the BMZ was histologically demonstrated by autoradiography. The IgG nature of the antibody was evidenced by the fact that it was absorbed by rabbit anti-human IgG antiserum immunoabsorbents. The peak antibody productionin vitro occurred after 6 days of culture. Antibody producedin vitro did not bind to the BMZ of human skin, but it did bind to the BMZ of the monkey esophagus. Normal human volunteers and control patients did not produce such an antibody. In other experiments the effects of adding serum containing anti-BMZ antibody to the synthesis of Ig by cells of patients and normal subjects were studied. Although serum from patients with bullous pemphigoid stimulated Ig production with either normal or BP-patient PBL, the difference was not statistically significant. The availability of the assay system allows for studying the immunoregulatory mechanism of autoantibody production in bullous pemphigoid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00915220
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  • 6
    Electronic Resource
    Electronic Resource
    Synthesis and antiviral evaluation of quinazoline, thieno-[2,3-d]pyrimidine, and lumazine analogues of 3′-fluoro-3′-deoxythymidine (FLT) (1995)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1995 (1995), S. 1371-1375 
    Details
    ISSN: 0947-3440
    Keywords: Nucleosides ; HIV ; 3′-Fluoronucleosides ; FLT analogues ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: 2,4(1H,3H)-Quinazolinediones 3a-c, lumazine (3d) and thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione (8) were silylated and condensed with methyl 2,3-dideoxy-3-fluoro-5-O-(4-phenylbenzoyl)-β-D-erythro-pentofuranoside (2) by using trimethylsilyl triflate as a catalyst to afford the corresponding cyclic nucleosides 4 and 9 and acyclic nucleosides 5 and 10. Removal of the protecting group from the glycon moiety was achieved in good yields by treatment with sodium methoxide in methanol at room temperature. The new FLT analogues were devoid of activity against HIV-1 and HSV-1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.1995199507183
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  • 7
    Electronic Resource
    Electronic Resource
    Evaluation of Dead Time Calculation in Reversed-Phase Liquid Chromatography Using a Multiparametric Mathematical Method (1999)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 22 (1999), S. 559-564 
    Details
    ISSN: 0935-6304
    Keywords: Liquid chromatography ; dead time ; multiparametric least-squares adjustment ; homologous series ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---In reversed phase liquid chromatography (RP-HPLC), the validity of a multiparametric non-linear least-squares regression iterative method for the determination of the column dead time tM and the regression parameter (slope b), based on the use of alkan-2-ones, alkyl aryl ketones, and 1-nitroalkanes has been evaluated. The determination of tM and b has been extensively studied for two mobile phase systems acetonitrile-water and methanol-water on seven octadecyl-C18 and one octyl C8 analytical columns. The calculated tM and b values were compared with those obtained by Guardino's and Grobler's methods. The influence exerted thereon by the nature of the homologous series, the mobile phase composition, and the packing materials were investigated.
    Additional Material: 5 Tab.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Mathematical dead time determination and calculation of the constants of the n-alkane retention time curve on OV polymethyl phenylsilicone stationary phases in gas chromatography (1986)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 9 (1986), S. 456-460 
    Details
    ISSN: 0935-6304
    Keywords: Gas chromatography ; Theory ; Mathematical dead time ; Methylphenylsiloxane stationary phases ; Constants of the n-alkane retention time curve ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The column dead time and the constants of the n-alkane retention time curve in gas-liquid chromatography are calculated by the Wentworth iterative method on series of OV polymethylphenylsilicones with an increasing percentage of phenyl substituent. The values obtained are in good agreement with those calculated by the methods of Gröbler and Kaiser and with the experimental ones reported in the literature for stationary phases studied at 120°C and 150°C. The scatter of experimental retention times of n-alkanes and tM and b and c and Kováts retention indices are calculated.
    Additional Material: 5 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240090808
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  • 9
    Electronic Resource
    Electronic Resource
    Carbon-13 shielding tensors for metal acetates (1992)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 30 (1992), S. 908-910 
    Details
    ISSN: 0749-1581
    Keywords: Magic-angle spinning ; Spinning ; sideband ; analysis ; Shielding tensors ; Metal acetates ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Carbon-13 shielding tensor data for eight metal acetates, obtained by analysis of spinning sideband manifolds of slowspinning CP/MAS spectra, are presented and discussed.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrc.1260300921
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  • 10
    Electronic Resource
    Electronic Resource
    Sulphur-33 and oxygen-17 NMR studies of sulpholane in acetic acid and related solvents (1990)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 28 (1990), S. 318-323 
    Details
    ISSN: 0749-1581
    Keywords: Sulphur-33 ; Oxygen-17 ; Sulpholane ; Line widths ; Protonation ; Medium effects ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Sulphur-33 NMR spectra were obtained for sulpholane in acetic acid, trifluoroacetic acid, methyl acetate and methyl trifluoroacetate over the entire solution range and at a variety of temperatures. Oxygen-17 NMR spectra were recorded for both components of each solution. The line width and chemical shift data are discussed in terms of molecular interactions and viscosity variations. Some variable-temperature measurements are included, as are some values of 13C spin-lattice relaxation times. It is concluded that there is an interaction, probably protonation, between sulpholane and trifluoroacetic acid, although occurring to only a small extent, which is not shown by the other solutions. The 33S and 17O line widths of sulpholane are peculiarly sensitive to the interaction.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrc.1260280408
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