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  • Chemistry  (37)
  • Analytical Chemistry and Spectroscopy  (7)
  • Genetics  (3)
  • HIV  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Cognitive Processing Style, Mood, and Immune Function Following HIV Seropositivity Notification (1997)
    Springer
    Cognitive therapy and research 21 (1997), S. 157-184 
    Details
    ISSN: 1573-2819
    Keywords: cognitive processing ; trauma ; mood ; HIV ; avoidance ; immunity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Psychology
    Notes: Abstract The relations among cognitive processing of stressful emotional material, mood, and immune functioning were examined in 30 asymptomatic gay men during the stress of HIV-1 seropositivity notification. We administered the Impact of Event Scale, and immunological and mood data were collected 5 weeks before, 1 week after, and 5 weeks after notification of HIV-1 seropositivity. Consistent elevations of avoidance or intrusion levels during the study period did not predict distress at 5 weeks postdiagnosis; rather, increased levels of both avoidance and intrusion over the study period were related to significantly greater anxiety, depression, and total mood disturbance by the end of the study. Increased intrusion, but not avoidance, during the period from study entry to 1-week postdiagnosis was related to higher levels of distress 1 week after HIV serostatus notification. In contrast, in the weeks following serostatus notification, increased avoidance predicted worse mood outcomes. Increased avoidance over the 10-week study period significantly predicted poorer proliferative response to pokeweed mitogen as well as trends toward lower T-helper-inducer lymphocyte (CD4+) percentages. Increased intrusion over this time period significantly predicted lower CD4+ percentages, controlling statistically for baselines. Mood change during the 10-week study did not mediate effects of cognitive processing on immune function. Mood changes may work jointly with cognitive processing to influence some immune outcomes. As increases in avoidant and intrusion processing may reflect difficulties in working through the trauma of HIV seropositivity notification, the current findings suggest the importance of thorough cognitive processing of traumatic medical information in this population for subsequent adjustment and immune functioning.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1021880612642
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  • 2
    Electronic Resource
    Electronic Resource
    A molecular dynamics study of thermodynamic and structural aspects of the hydration of cavities in proteins (1991)
    New York : Wiley-Blackwell
    Biopolymers 31 (1991), S. 919-931 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The structure and activity of a protein molecule are strongly influenced by the extent of hydration of its cavities. This is, in turn, related to the free energy change on transfer of a water molecule from bulk solvent into a cavity. Such free energy changes have been calculated for two cavities in a sulfate-binding protein. One of these cavities contains a crystallo graphically observed water molecule while the other does not. Thermodynamic integration and perturbation methods were used to calculate free energies of hydration for each of the cavities from molecular dynamics simulations of two separate events: the removal of a water molecule from pure water, and the introduction of a water molecule into each protein cavity. From the simulations for the pure water system, the excess chemical potential of water was computed to be -6.4 ± 0.4 kcal/mol, in accord with experiment and with other recent theoretical calculations. For the protein cavity containing an experimentally observed water molecule, the free energy change on hydrating it with one water molecule was calculated as -10.0 ± 1.3 kcal/mol, indicating the high probability that this cavity is occupied by a water molecule. By contrast, for the cavity in which no water molecules were experimentally observed, the free energy change on hydrating it with one water molecule was calculated as 0.2 ± 1.5 kcal/mol, indicating its low occupancy by water. The agreement of these results with experiment suggests that thermodynamic simulation methods may become useful for the prediction and analysis of internal hydration in proteins.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.360310802
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  • 3
    Electronic Resource
    Electronic Resource
    Design and Synthesis of Potent Macrocyclic Benzolactam Growth Hormone SecretagoguesDedicated to the Memory of Professor Wolfgang Oppolzer.2Deceased March 15, 1996. (1997)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 80 (1997), S. 1244-1259 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The synthesis of a variety of potent macrocyclic growth hormone secretagogues, i.e. 5, 9, 12, and 20-22, based on the known lead structure L-692,429 (1) is described. These conformationally constrained growth hormone secretagogues were prepared by joining the two essential pharmacophores, the amino-acid side chain at the 1H-1-benzazepine moiety and the 1,1′-biphenyl moiety with a variety of linkers. The most potent analog was found to be L-744,080 (21), a derivative in which a 2′-carboxamide moiety at 1,1-biphenyl is N,O-joined to the OH group of the (2-hydroxypropyl)amino-acid side chain by a C4 ester linker. This potent analog may be useful in determining the bound conformation of the benzolactam class of growth hormone secretagogues at the newly identified GHS receptor, L-744,080 (21) with an ED50 of 20 nM was up to fifty times more potent than the seco-acid precursor and 3-fold more potent than the parent 2′-tetrazole compound L-692, 429 (1).
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19970800421
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  • 4
    Electronic Resource
    Electronic Resource
    Qualitative and quantitative high performance liquid chromatographic analysis of monoamine neurotransmitters and metabolites in cerebrospinal fluid and brain tissue using reductive electrochemical detection (1990)
    New York, NY : Wiley-Blackwell
    Biomedical Chromatography 4 (1990), S. 215-220 
    Details
    ISSN: 0269-3879
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The application of reductive coulometric electrochemical detection for analysis of the monoamine neurotransmitters norepinephrine, dopamine, and serotonin and their common metabolites in brain and cerebrospinal fluid following separation by isocratic high performance liquid chromatography is described. The high sensitivity and screening capabilities of coulometric electrodes permits the accurate quantitation of as little as 3-5 pg of these compounds in tissue following a simple single step purification procedure. Moreover, comparison of peak height ratios obtained from analysis of authentic reference standards and tissue samples at selected multiple electrode potentials provides a straightforward means for qualitative evaluation of peak identification and purity during analysis of biological samples. The method is comparatively inexpensive and precise within and between day coefficients of variation for most compounds range from 2-5%. Thirty samples can be run in duplicate in a 24 h period.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bmc.1130040509
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  • 5
    Electronic Resource
    Electronic Resource
    Structure and properties of p-carboxysuccinanilic polyester resins (1988)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 35 (1988), S. 75-83 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Polyester resins were prepared by the reaction of p-carboxysuccinanilic acid ethyl ester with ethylene glycol and 1,4-butenediol. Also, unsaturated polyester resins were prepared by the copolymerization of p-carboxysuccinanilic acid ethyl ester and maleic anhydride with ethylene glycol, 1,6-hexanediol, 1,4-butenediol, and 2-butyne-1,4-diol. All the polyester resins and the copolyesters have been characterized and were found to cure with styrene, except those prepared in the absence of maleic anhydride. The properties of the cured products in the form of films were determined. Infrared and nuclear magnetic resonance (NMR) spectroscopy were used for both qualitative and quantitative analyses of the polyester resins and their hydrolyzate products after curing with styrene.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1988.070350107
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  • 6
    Electronic Resource
    Electronic Resource
    Stabilization of λ repressor against thermal denaturation by site-directed Gly→Ala changes in α-helix 3 (1986)
    New York, NY : Wiley-Blackwell
    Proteins: Structure, Function, and Genetics 1 (1986), S. 43-46 
    Details
    ISSN: 0887-3585
    Keywords: protein stability ; helix-coil ; mutant ; calorimetry ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Oligonucleotide-directed mutagenesis has been used to replace α-helical glycines in the N-terminal domain of λ repressor with alanines. Since alanine is a significantly better helix-forming residue than glycine, these changes were predicted to have a stabilizing effect. We show that the Gly46→Ala substitution, the Gly48→Ala substitution, and the double substitution increase the melting temperature of the N-terminal domain by 3-6°.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prot.340010108
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  • 7
    Electronic Resource
    Electronic Resource
    Microanalysis of polymers using a windowless energy-dispersive X-ray detector (1988)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 26 (1988), S. 201-206 
    Details
    ISSN: 0887-624X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The surface compositions of various polymeric films, grown electrochemically on platinum foils, have been investigated by energy-dispersive x-ray analysis in conjunction with scanning electron microscopy (SEM/EDS). Comparison of the relative area ratios of peaks for the C and N Kemission lines show that the EDS may be used to study the surface composition of polymers. The evidence presented strongly suggests that there is limited structural degradation and the elemental composition is not changed under the electron beam at relatively low accelerating voltages. This technique statistically samples the repeat units of the polymer. For samples grown in both aqueous and nonaqueous solutions. SEM/EDS provides evidence for extensive contamination with oxygen.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pola.1988.080260120
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  • 8
    Electronic Resource
    Electronic Resource
    Thermal properties of some fully aromatic thermotropic liquid crystal polyesters (1990)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 28 (1990), S. 75-87 
    Details
    ISSN: 0887-624X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Wholly aromatic liquid crystalline main chain polyesters derived from terephthalic acid, phenyl- or (1-phenylethyl)hydroquinone modified with either 3,4′- or 4,4′-dicarboxydiphenylether and p-hydroxybenzoic acid, have been prepared by acidolysis and thermally investigated. All prepared polyesters exhibit excellent thermal stability up to about 400°C, however, the (1-phenylethyl)hydroquinone polyesters generally showed lower stability. Melting points could be decreased to around 200°C without any decrease in the thermal stability or the nematic range.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pola.1990.080280106
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  • 9
    Electronic Resource
    Electronic Resource
    Characteristics of African-Americans with multiple risk factors associated with HIV/AIDS (1996)
    Springer
    Journal of behavioral medicine 19 (1996), S. 55-71 
    Details
    ISSN: 1573-3521
    Keywords: African-Americans ; AIDS ; anger ; attitudes ; condom use ; HIV ; knowledge
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Psychology
    Notes: Abstract Multiple risk factors in young African-Americans have tremendous implications for the spread of AIDS. Two hundred forty-two heterosexual college students were classified as having low, moderate, or high risk for HIV infection based upon their self-reported sexual practices. Results indicated that subjects differed in AIDS knowledge and attitudes toward condoms with respect to both Gender and Risk level, with men and High Risk individuals being less knowledgeable and having more negative attitudes than their female and Low Risk counterparts respectively. Interaction effects revealed that High Risk men were less knowledgeable than both Low Risk men and High Risk women. High Risk men as well as High and Low Risk women reported more anger surrounding condom usage than Low Risk men. Low perceptions of vulnerability for AIDS were reflected in the entire sample. The implications of this study for primary prevention and future research are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01858174
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  • 10
    Electronic Resource
    Electronic Resource
    Reductions in Salivary Cortisol Are Associated with Mood Improvement During Relaxation Training Among HIV-Seropositive Men (2000)
    Springer
    Journal of behavioral medicine 23 (2000), S. 107-122 
    Details
    ISSN: 1573-3521
    Keywords: salivary cortisol ; relaxation ; HIV ; mood
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Psychology
    Notes: Abstract This study examined salivary cortisol and mood during relaxation training in 30 symptomatic, HIV+ gay men participating in a 10-week, group-based cognitive-behavioral stress management intervention. Cortisol levels and mood were assessed within these sessions just before and after 45-min relaxation exercises given as part of each session. Participants also recorded their stress level and compliance with daily home relaxation practice. Presession cortisol levels decreased across the 10-week period and were related to decreases in global measures of total mood disturbance and anxious mood. Reductions in presession cortisol levels were also associated with decreases in self-reported stress level during home practice. Greater reductions in cortisol during the first three sessions were associated with more frequent relaxation practice at home. These findings suggest that salivary cortisol represents an objective neuroendocrine marker for changes in anxiety and distress observed during relaxation training in symptomatic, HIV-seropositive men.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005419917023
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