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Genetic selection in presence of pathogens such as the lymphoid leukosis virus: computer simulation (1984)

Harris, D. L. ; Gavora, J. S. ; Spencer, J. L.

Springer

Theoretical and applied genetics 68 (1984), S. 397-413

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ISSN: 1432-2242

Keywords: Quantitative genetics ; Selection response ; Chickens ; Lymphoid leukosis ; Egg production ; Computer simulation

Source: Springer Online Journal Archives 1860-2000

Topics: Biology

Notes: Summary A computer model was developed to simulate the population dynamics involved when selection is for a trait influenced by the presence of a pathogen in addition to quantitative genetic factors. The lymphoid leukosis virus is such a pathogen, when selection is for egg production in chickens. It is transmitted congenitally from dam to offspring and horizontally from one individual to another. For these simulations, individual selection for high performance in the trait influenced by the pathogen was more effective than family selection for removing infected individuals from populations. The resulting reduction in the incidence of infected individuals in following generations made the overall response to individual selection greater than for family selection. However, the virus would remain in most populations due to horizontal transmission to individuals which later transmit the virus to their offspring. These horizontally infected individuals would not be eliminated in the selection process because their egg production was assumed to be less reduced than that of congenitally infected birds. These simulation results seem to mimic certain experimental results which heretofore have been difficult to explain since they were not consistent with quantitative genetic theoretical expectations from selection.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00254807

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Mass spectrometric analyses and characterization of Kepone in environmental and human samples (1978)

Harless, R. L. ; Harris, D. E. ; Sovocool, G. W. ; [et al.]

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 5 (1978), S. 232-237

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ISSN: 0306-042X

Keywords: Chemistry ; Analytical Chemistry and Spectroscopy

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: A specific portion of our environment has been contaminated with Kepone, or chlordecone. Additionally, some specific human exposures to high concentrations of Kepone have been confirmed. Gas chromatography mass spectrometry involving chemical ionization and high resolution mass spectrometry were used to detect, identify and confirm the presence of Kepone, Kepone photoproducts and a reduction product of Kepone in environmental and human samples. Field desorption, field ionization and electron impact mass spectrometric methods, as well as infrared and nuclear magnetic resonance techniques were used to characterize and identify Kepone hydrate and hemiketal in benzene and methanol solutions, respectively.

Additional Material: 8 Ill.