ISSN:
0306-042X
Keywords:
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The identification of biotransformation products of the new antihypertensive drug urapidil in mouse, rat, dog and man has been performed by means of high-performance liquid chromatographic and mass spectrometric techniques. In urine, three metabolites were found in addition to the unchanged drug. The para-hydroxylated product (1) (6-{3-[4-(o-methoxy-p-hydroxyphenyl) piperazinyl]-propylamino}-1,3-dimethyl-uraci), the O-demethylated compound (2) (6-{3-[4-(o-hydroxyphenyl) piperazinyl]-propylamino}-1,3-dimethyluracil) and the uracil-N-dealkylated compound (3) (6-{3-[4-(o-methoxyphenyl)piperazinyl]-propylamino}-1-methyl-uracil). In urine of dog, the metabolite with the N-oxide structure (5) was also identified, but only in trace arnounts (6-{3-[4-(o-methoxyphenyl)piperazinyl-N-oxide]-propylamino}-1,3-dimethyluracil).
Additional Material:
5 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/bms.1200110504
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