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  • 1
    Electronic Resource
    Electronic Resource
    Packed column supercritical fluid chromatography/mass spectrometry using a thermospray source in the filament-on mode (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 105-109 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Combined packed column supercritical fluid chromatography/mass spectrometry has been effected using a thermospray ion source in the filament-on mode. If organic modifiers are used with carbon dioxide as the supercritical mobile phase, chemical ionization mass spectra are obtained. With carbon dioxide electron impact type mass spectra are obtained. The potential of the system is illustrated with studies of mixtures of carbamate and organochlorine pesticides and a crude ergot fermentation extract.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200150208
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  • 2
    Electronic Resource
    Electronic Resource
    Continuous flow fast atom bombardment liquid chromatography/mass spectrometry: Studies involving conventional bore liquid chromatography with simultaneous ultraviolet detection (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 179-182 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A conventional bore liquid chromatograph has been interfaced to quadrupole and magnetic sector mass spectrometers configured for fast atom bombardment ionization via a continuous flow FAB probe. It is shown that post-column addition of FAB matrix and in-line ultraviolet detection facilities do not significantly compromise chromatographic integrity and that high quality mass spectra are obtainable from such FAB LC/MS studies.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200150310
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  • 3
    Electronic Resource
    Electronic Resource
    Detection of residues of chloramphenicol in crude extracts of fish and milk by tandem mass spectrometry (1989)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 18 (1989), S. 5-11 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The collision-induced dissociation mass spectrum, observed with a hybrid tandem instrument, of the ammonia chemical ionization protonated molecular ion of chloramphenicol was used for the detection of residues of the drug in biological samples. The extracted oil from fish was subjected to a rapid clean-up on a pre-packed silica gel cartridge prior to non-chromatographic tandem mass spectral analysis. Fat extracted from milk was analysed directly by on-line combined high-performance liquid chromatography/tandem mass spectrometry with rapid elution of chloramphenicol. Identification was on the basis of agreement of the daughter ion spectra obtained from sample extracts with that of the chloramphenicol standard. Detection was unambiguous at 0.5 mg kg-1. The sensitivity advantage normally expected with multiple reaction monitoring was not achieved owing to the effect of neutral noise phenomena.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200180103
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  • 4
    Electronic Resource
    Electronic Resource
    Analysis of conjugated bile acids by on-line supercritical fluid chromatography/thermospra mass spectrometry (1992)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 27 (1992), S. 1266-1270 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A rapid method was developed for the analysis or polar conjugated bile acids by combined packed column super-critical fluid chromatography/mass spectrometry. Direct coupling of the column to the mass spectrometer was effected with a modified thermospray interface operated in the filament-on mode. Maximum sensitivity for the bile acid conjugates was achieved by recording the negative ions generated in the ionization process. The effects of vaporizer and source temperatures, repeller voltage and discharge conditions on the bile acid response were investigated. The mass spectra obtained for the common glycine and taurine conjugates yielded only the [M - H]- pseudo-molecular ions. In contrast with the taurine derivatives, the glycine forms produced a weak ion current and exhibited broad hands. The applicability of the technique is illustrated with a sample of human bile.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210271119
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  • 5
    Electronic Resource
    Electronic Resource
    Proton-transfer reactions of mass-selected multiply charged ions (1994)
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 8 (1994), S. 417-422 
    Details
    ISSN: 0951-4198
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: A triple-quadrupole spectrometer has been used to study proton-transfer reactions of multiply charged ions generated by electrospray ionization. Doubly and triply charged ions generated from the peptides Arg-Lys-Glu-Val-Tyr and Met-Lys-bradykinin, respectively, were found to undergo proton-transfer reactions with ammonia molecules contained in the RF-only quadrupole collision-gas cell of the spectrometer. With horse-heart myoglobin in the source, ions having charges of 20+, 19+, 16+ and 14+ were selected in turn by the first quadrupole and their proton-transfer reactions with ammonia investigated. For each ion, numerous product ions were detected having charges (n-1)+, (n-2)+, (n-3)+ … where n was the charge on the reacting parent ion. The possibility of using the experimental technique to measure approximately the proton affinities of multiply charged ions is discussed. Also, a procedure is outlined for identifying the charge states of product ions resulting from collision-induced dissociation of multiply charged ions.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/rcm.1290080515
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  • 6
    Electronic Resource
    Electronic Resource
    The complexation and chiral selectivity of 2-hydroxypropyl-β-cyclodextrin with guest molecules as studied by electrospray mass spectrometry (1994)
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 8 (1994), S. 423-426 
    Details
    ISSN: 0951-4198
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: Electrospray mass spectrometry has been used to study the complexation of ‘guest’ molecules with a mixture of hydroxypropyl-substituted β-cyclodextrin derivatives. In all cases studied, the predominant derivative was shown to contain a maximum of seven hydroxypropyl groups, most probably related to alkylation of each of the seven glucose units of the parent β-cyclodextrin. Chiral selectivity was not observed for D- and L-phenylalanine methyl esters. In contrast D-propranolol and L-tryptophan methyl ester formed stronger complexes than the corresponding L- and D-enantiomers, respectively. Molecular modelling studies were also carried out, in an attempt to identify the factors that can play a part in determining the mechanism of the observed non-covalent interactions.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/rcm.1290080516
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  • 7
    Electronic Resource
    Electronic Resource
    An investigation into the stereochemistry of the boronate di-esters of some monosaccharides using tandem mass spectrometry (1993)
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 7 (1993), S. 1099-1107 
    Details
    ISSN: 0951-4198
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: The aim of this work was to probe the stereochemistry of a series of monosaccharides. Firstly, the underivatized sugars were investigated using linked-scans and tandem mass spectrometry on a ‘hybrid’ instrument (hybrid MS/MS) and secondly, a comparison of linked-scan and hybrid MS/MS was carried out on the butyl and phenyl boronate di-esters. In situ derivatization of the sugar to the boronate di-ester allows a negative-ion fast-atom bombardment (FAB) investigation with greater sensitivity than for the underivatized sugar. The linked-scan data allow a great deal of information on the structure and chemistry of the sugars to be obtained, but the sensitivity at lower mass is limited. The hybrid MS/MS data give similar fragmentation information, plus improved sensitivity at lower molecular weight.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/rcm.1290071209
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  • 8
    Electronic Resource
    Electronic Resource
    Calculated and measured double-ionization energies of 1,1-dimethyl allene to triplet electronic states of the dication (1994)
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 8 (1994), S. 913-916 
    Details
    ISSN: 0951-4198
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: Double ionization of the 1,1-dimethyl allene molecule to triplet electronic states of the dication has been studied using theoretical and experimental methods. Although the calculated data indicate a high density of states, suitable groupings of calculated double-ionization energies to those states agree well with values measured by double-charge-transfer spectroscopy. This indicates that the theoretical predictions provide an accurate indication of the composition of the triplet-state manifold for the 1,1-dimethyl allene dication between 25.2 eV and 39.6 eV.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/rcm.1290081110
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  • 9
    Electronic Resource
    Electronic Resource
    Chromatographic and mass spectrometric methods for the identification of phosphorylation sites in phosphoproteins (1994)
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 8 (1994), S. 559-570 
    Details
    ISSN: 0951-4198
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: The phosphorylation sites in a model phosphoprotein, αsl-casein from bovine milk, have been identified by tryptic peptide mapping (Gibson and Cohen, Methods Enzymol. vol. 193, p. 480 (1990)) employing reversed-phase high performance liquid chromatography (RPHPLC)/electrospray ionization mass spectrometry (ES-MS); by infusion tandem mass spectrometry (MS/MS) and LC/MS/MS in neutral loss mode of tryptic digests of αsl-casein, in which the characteristic neutral loss of phosphoric acid by phosphopeptides under collision-induced dissociation (CID) conditions is exploited to highlight phosphopeptides in a tryptic digest (Covey et al., in Methods in Protein Sequence Analysis, Jörnvall et al. (Eds), Birkhäuser Verlag, Basel 1991), and by a novel method, termed LC/CID-MS, in which phosphopeptides are located in mixtures of peptides by the generation and detection of phosphate-specific fragment ions during LC/ES-MS (Huddleston et al., J. Am. Soc. Mass Spectrom. vol. 4, p. 710 (1993)). An appraisal of the efficiency, sensitivity and practicality of each of these methods in the identification of phosphorylation sites in post-translationally modified proteins is given.
    Additional Material: 20 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/rcm.1290080713
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  • 10
    Electronic Resource
    Electronic Resource
    Evaluation of glycosylation site heterogeneity and selective identification of glycopeptides in proteolytic digests of bovine α1-acid glycoprotein by mass spectrometry (1995)
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 9 (1995), S. 42-56 
    Details
    ISSN: 0951-4198
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: Glycosylation sites in bovine α1-acid glycoprotein (AGP) have been identified, and the inherent heterogeneity evaluated, by capillary electrophoretic and reversed-phase liquid chromatography/electrospray-mass spectrometric analyses of proteolytic digests of this glycoprotein. The success of these methods in locating glycopeptides relied on significant heterogeneity within each glycosylation site. In order to rapidly locate sites in glycoproteins of any degree of heterogeneity, a novel mass spectrometric method was applied to selectively identify the glycopeptides in a proteolytic digest of bovine α1-AGP. The glycopeptides were selectively located by the generation and detection of characteristic oxonium ions from the carbohydrate moieties by collision-induced dissociation (CID) during liquid chromatography/electrospray-tandem mass spectrometry, and liquid chromatography/CID mass spectrometry, in which fragmentation was induced in the supersonic expansion region of the electrospray source.
    Additional Material: 19 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/rcm.1290090111
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