ISSN:
0935-6304
Keywords:
Thin-layer Chromatography, TLC/HPTLC
;
Quantitation by optical in-situ scanning
;
Comparison of conventional and HPTLC techniques
;
Peripheral quantitized circular HPTLC superior
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Conventional TLC, linear and circular HPTLC are compared by using In-situ reflectance measurements. Chromatographic resolution, time requirement and reproducibility of quantitative scanning of the different TLC methods are investigated by means of three separation problems: benzodiazepines, corticosteroids, polycyclic aromatic hydrocarbons.In all three application examples, which were chosen without prejudice, the circular developing mode with subsequent quantitative scanning showed certain advantages over the corresponding linear HPTLC techniques. These were in the case of Benzodiazepines: Better reproducibility of quantitative assessment.Corticosteroids: Better resolution and slightly better quantitative reproducibility.Polycyclic aromatic hydrocarbons: Chromatography considerably faster.
Additional Material:
11 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jhrc.1240020306
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