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  • 1
    Electronic Resource
    Electronic Resource
    Simple pyrolysis chamber modification for capillary column curie-point pyrolysis gas chromatography - mass spectrometry of complex biomaterials (1986)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 9 (1986), S. 596-597 
    Details
    ISSN: 0935-6304
    Keywords: Gas chromatography, GC ; Gas chromatography-mass spectrometry, GCMS ; Curie-point pyrolysis ; Biomaterials ; Biomass ; Foodstuffs ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240091013
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  • 2
    Electronic Resource
    Electronic Resource
    New automatic sampler for Curie-Point pyrolysis its combination with gas chromatography (1987)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 10 (1987), S. 467-469 
    Details
    ISSN: 0935-6304
    Keywords: GC/FTIR/MS coupling ; Curie-point pyrolysis ; Programmable automatic multisampler ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240100812
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  • 3
    Electronic Resource
    Electronic Resource
    High resolution field desorption mass spectrometry: II - glycosides (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 120-123 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The high resolution field desorption mass spectra of a number of glycosides are described. In all cases the spectra enabled molecular weights and elemental formulae to be established, and the presence of fragment ions due to cleavage of the sugar groups provides considerable assistance in the identification of sugar and aglycone moieties. The [M + 23Na]+ ion was the base peak in the spectrum of the sodium salt of testosterone glucuronide, and the presence [M + 39K]+, [M + 41K]+ and [M + 23Na]+ ions in the spectra of other glycosides are attributed to the presence of their sodium or potassium salts as impurities.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010207
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  • 4
    Electronic Resource
    Electronic Resource
    Quality control of radiolabelled biochemicals by field desorption mass spectrometry (1980)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 7 (1980), S. 468-472 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Biochemicals labelled with carbon-14 and hydrogen-3 have been examined for their specific radioactivity by field desorption mass spectrometry, and the data obtained are compared with those derived from the combined use of chromatographic methods and liquid scintillation counting. The special methodology, and the advantages and drawbacks of these quantitative mass spectrometric determinations are discussed. First data on the interlaboratory reproducibility of quantitative field desorption mass spectrometry are reported.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200071105
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  • 5
    Electronic Resource
    Electronic Resource
    An emission-controlled field desorption and electron impact spectrometry study of some N-substituted propane and butane sultams (1977)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 4 (1977), S. 55-61 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: It is shown that the production of field desorption mass spectra with an emission-controlled emitter heating device is a useful tool in obtaining information about molecular structures. Since the structurally significant signals are sometimes missing in the corresponding electron impact spectra but not in the field desorption spectra the use of field desorption mass spectrometry appears to be more advantageous. This will be especially true for substances that are thermally labile, unvolatile or unstable upon electron impact (both at high and low electron energy), the latter being the case for some of the compounds presently investigated which are derivatives of a drug with antitumour and antiepileptic effects. Further, emission-controlled desorption improves the reproducibility of the spectra obtained and thus appears to be a prerequisite for quantification in biomedical and pharmacokinetic studies.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200040108
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  • 6
    Electronic Resource
    Electronic Resource
    Isolation, identification and determination of cyclophosphamide and two of its metabolites in urine of a multiple sclerosis patient by high pressure liquid chromatography and field desorption mass spectrometryQuantitative Field Desorption Mass Spectrometry-XXIV; for Part XXIII, see Ref. 20. (1981)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 8 (1981), S. 553-557 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The off-line combination of high pressure liquid chromatography and field desorption mass spectrometry has been used for the simultaneous isolation, identification and determination of cyclophosphamide and two of its metabolites, 4-ketocyclophosphamide and carboxyphosphamide in urine from a patient suffering from multiple sclerosis. Cyclophosphamide and its metabolites were separated using reverse phase liquid chromatography. Field desorption mass spectrometry was employed for identification and quantification. The technique applied needs no derivatization for analysis. The limits of detection by field desorption mass spectrometry for 1, 2 and 3 are a factor of about 4 × 103-105 lower than those of a common variable ultraviolet detector. Quantitative determination was carried out using the method of stable isotope dilution with deuterated analogues of 1, 2 and 3. In a pilot study, the ratio of 1:2:3 was determined to 1:0.02:0.6. One ml of urine is sufficient for simultaneous analysis of the three compounds. The typical analysis time, including separation by liquid chromatography and field desorption measurement, is about 30 minutes.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200081106
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  • 7
    Electronic Resource
    Electronic Resource
    Field desorption mass spectrometry of metabolites of the anticancer drug cyclophosphamide (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 223-230 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Some of the known and important metabolites of cyclophosphamide and the parent drug itself were investigated by low and high resolution field desorption mass spectrometry. The potential of the relatively new analytical method for the determination of the molecular weight and elemental formulae of drugs and drug metabolites was exemplified. This holds for pure, synthetic compounds as well as for contaminated extracts from biological sources. In addition, by thermally-/field-induced fragmentation, diagnostic fragment ions could be produced, providing valuable structural information. Further, an indication on how to distinguish [M]+. and [M + H]+ ions in field desorption mass spectrometry is given. The ability to identify these ions unambiguously is critical for interpretation. Finally, the potential of the method as applied to drug and drug metabolite mixtures is evaluated. The results indicate that field desorption mass spectrometry is a promising tool in metabolism studies.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010405
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  • 8
    Electronic Resource
    Electronic Resource
    Pyrolysis mass spectrometric studies on nucleic acids (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 352-357 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Two different mass spectrometric techniques have been used to analyse the products resulting from Curie-point pyrolysis of nucleic acids: low voltage ionization quadrupole mass spectrometry and high resolution field ionization mass spectrometry. The spectra obtained with both techniques are in good agreement with one another. As already indicated by the low resolution spectra, the high resolution spectra proved that most of the peaks originate from the carbohydrate moiety of the nucleic acid. Micrograms of DNA/RNA can be distinguished very easily by use of these key fragments, although the bases themselves are not found. Some significant pyrolysis mechanisms are proposed.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010512
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  • 9
    Electronic Resource
    Electronic Resource
    Field desorption mass spectra of stereoisomeric glycosides (1973)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 7 (1973), S. 1103-1108 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Field desorption mass spectrometry (FD-MS) yields differentiated spectra for unshielded α- and β-stereoisomeric glycosides. The small but characteristic differences enable a distinction to be made between the two isomers. Valuable structural information can be deduced from the simple cleavage between the sugar moiety of the molecule and the aglycon. A short comparison with electron-impact (EI) and field ionisation (FI) spectra is given.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210070911
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  • 10
    Electronic Resource
    Electronic Resource
    On the correlation between emitter heating current and emitter temperature in field desorption mass spectrometry (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 10 (1975), S. 813-816 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Calibration curves have been established that give an estimate of the temperature in the emission region of high temperature activated field desorption emitters. Two characteristic types of field anodes have been investigated: (1) emitter wires carrying microneedles of 25 to 30 μm length, preferentially used for field desorption of organic compounds; (2) emitters with microneedles of 50 to 60 μm length, which are used for the investigations of polymers by pyrolysis field desorption mass spectrometry.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210100918
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